Malabika Sen
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View article: Supplementary Figure 6 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Supplementary Figure 6 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
PDF file, 201KB, Biochemical effect of PDK1 targeting strategies on Akt and p70S6K.
View article: Supplementary Figure 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 2.5MB, The chemistry used to generate the modified decoys
View article: Data from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane
Data from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane Open
Chronic exposure to carcinogens represents the major risk factor for head and neck squamous cell carcinoma (HNSCC). Beverages derived from broccoli sprout extracts (BSE) that are rich in glucoraphanin and its bioactive metabolite sulforaph…
View article: Supplementary Figure Legend from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Supplementary Figure Legend from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
PDF File, 77KB.
View article: Supplementary Figure 5 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 5 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 2MB, Modified STAT3 decoys abrogate STAT3 target gene expression in vitro
View article: Supplementary Figure 3 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 3 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 2.2MB, Modified STAT3 decoys demonstrate enhanced resistance to thermal denaturation
View article: Supplemental Figure S1 from STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma
Supplemental Figure S1 from STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma Open
Parallel slopes indicate identical response to Stattic in PTPRT WT and KO mice. Vertical distance indicates improved outcome of Stattic-treated mice compared to vehicle-treated.
View article: Supplementary Figure 6 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 6 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 122K, STAT3 decoy treatment does not inhibit cell viability or STAT3 target gene expression in A4 STAT3 null cells
View article: Supplementary Table 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Table 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 165K, EC50 values of STAT3 decoy in cancer cell lines
View article: Supplementary Materials and Methods from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane
Supplementary Materials and Methods from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane Open
Supplementary Materials and Methods.
View article: Supplementary Figure Legends and Table Legends from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane
Supplementary Figure Legends and Table Legends from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane Open
Supplementary Figure Legends and Table Legends.
View article: Data from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Data from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
G-protein–coupled receptors (GPCR) activate the epidermal growth factor receptor (EGFR) and mediate EGFR-independent signaling pathways to promote the growth of a variety of cancers, including head and neck squamous cell carcinoma (HNSCC).…
View article: Supplementary Table 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Table 2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 165K, EC50 values of STAT3 decoy in cancer cell lines
View article: Supplementary Figure 7 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 7 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 107K, Systemic delivery of cyclic STAT3 decoy does not affect total or pSTAT3 expression levels
View article: Supplementary Materials and Methods from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane
Supplementary Materials and Methods from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane Open
Supplementary Materials and Methods.
View article: Supplementary Table 1 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Supplementary Table 1 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
PDF file, 39KB, IC50 values for AR-12 in HNC and 1 normal cell line.
View article: Data from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Data from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
G-protein–coupled receptors (GPCR) activate the epidermal growth factor receptor (EGFR) and mediate EGFR-independent signaling pathways to promote the growth of a variety of cancers, including head and neck squamous cell carcinoma (HNSCC).…
View article: Supplementary Figure 3 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Supplementary Figure 3 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
PDF file, 453KB, PDK1 contributes to HNSCC sensitivity to AR-12.
View article: Supplementary Table from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane
Supplementary Table from Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane Open
Supplementary Table 1 This Table presence of SF metabolites in patient urine specimens.
View article: Supplementary Figure 1 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 1 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 70K, Lack of anti-tumor effects of systemically administered parental STAT3 decoy
View article: Supplementary Figure 4 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 4 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 1.2MB, Modified STAT3 decoys bind to pSTAT3 protein with similar affinity as the parental STAT3 decoy
View article: Supplementary Figure 6 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure 6 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 122K, STAT3 decoy treatment does not inhibit cell viability or STAT3 target gene expression in A4 STAT3 null cells
View article: Supplementary Table 1 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Table 1 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 23K, Quantitative determination of the binding affinities of the parent and modified STAT3 decoys
View article: Supplementary Figure 4 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Supplementary Figure 4 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
PDF file, 106KB, AR-12 decreases cyclin D1 expression.
View article: Data from STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma
Data from STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) is a frequently fatal disease due, in large part, to a high rate of second primary tumor (SPT) formation. The 4-nitroquinoline 1-oxide (4-NQO) mouse model of oral carcinogenesis provides a robu…
View article: Supplementary Figure Legends 1-7, Table Legends 1-2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Supplementary Figure Legends 1-7, Table Legends 1-2 from First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy Open
PDF file - 70K
View article: Supplementary Figure Legend from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Supplementary Figure Legend from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
PDF File, 77KB.
View article: Supplemental Figure Legend from STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma
Supplemental Figure Legend from STAT3 as a Chemoprevention Target in Carcinogen-Induced Head and Neck Squamous Cell Carcinoma Open
Supplemental Figure Legend.
View article: Supplementary Figure 5 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer
Supplementary Figure 5 from Antitumor Mechanisms of Targeting the PDK1 Pathway in Head and Neck Cancer Open
PDF file, 289KB, Phosphorylated MAPK and AKT abrogated in C225-treated PDKM xenografts.