Malavika Murugan
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View article: Comparative gene editing reduces dopamine receptor levels across rodent species
Comparative gene editing reduces dopamine receptor levels across rodent species Open
Translational challenges in neuroscience originate from species-specific differences that limit the generalizability of experimental findings. Comparative approaches can help distinguish conserved from species-specific mechanisms, but thei…
View article: Non-overlapping social and food reward representations in the basolateral amygdala
Non-overlapping social and food reward representations in the basolateral amygdala Open
The ability to consider and appraise positively valenced stimuli in the environment, such as food and social interaction, to guide appropriate action is important for survival of most animals. Several studies have compared how food and soc…
View article: Organization of Brainwide Inputs to Discrete Lateral Septum Projection Populations
Organization of Brainwide Inputs to Discrete Lateral Septum Projection Populations Open
The lateral septum (LS) is anatomically positioned to play a critical role in directing information from the hippocampus and cortex to downstream subcortical structures, such as the hypothalamus. Early anatomical tracing studies investigat…
View article: A ventral hippocampal-lateral septum pathway regulates social novelty preference
A ventral hippocampal-lateral septum pathway regulates social novelty preference Open
The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with …
View article: Organization of brainwide inputs to discrete lateral septum projection populations
Organization of brainwide inputs to discrete lateral septum projection populations Open
The lateral septum (LS) is anatomically positioned to play a critical role in directing information from the hippocampus and cortex to downstream subcortical structures, such as the hypothalamus. In fact, early anatomical tracing studies i…
View article: Protocol for the quantitative assessment of social and nonsocial reward-seeking in mice using an automated two choice operant assay
Protocol for the quantitative assessment of social and nonsocial reward-seeking in mice using an automated two choice operant assay Open
The complexity of social behaviors makes it difficult to study the neural mechanisms that underlie them. Here, we describe an automated, low-cost two choice operant assay to directly compare social and nonsocial reward-seeking in mice. We …
View article: A ventral hippocampal-lateral septum pathway regulates social novelty preference
A ventral hippocampal-lateral septum pathway regulates social novelty preference Open
The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with …
View article: A ventral hippocampal-lateral septum pathway regulates social novelty preference
A ventral hippocampal-lateral septum pathway regulates social novelty preference Open
The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with …
View article: Reviewer #2 (Public Review): A ventral hippocampal-lateral septum pathway regulates social novelty preference
Reviewer #2 (Public Review): A ventral hippocampal-lateral septum pathway regulates social novelty preference Open
The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with …
View article: Reviewer #1 (Public Review): A ventral hippocampal-lateral septum pathway regulates social novelty preference
Reviewer #1 (Public Review): A ventral hippocampal-lateral septum pathway regulates social novelty preference Open
The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with …
View article: A ventral hippocampal-lateral septum pathway regulates social novelty preference
A ventral hippocampal-lateral septum pathway regulates social novelty preference Open
The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability to recognize kin and familiar individuals and engage in appropriate behaviors is associated with …
View article: Overlapping representations of food and social stimuli in VTA dopamine neurons
Overlapping representations of food and social stimuli in VTA dopamine neurons Open
Summary Dopamine neurons of the ventral tegmental area (VTA DA ) respond to food and social stimuli and contribute to both forms of motivation. However, it is unclear if the same or different VTA DA neurons encode these different stimuli. …
View article: Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex
Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex Open
The reinforcing nature of social interactions is necessary for the maintenance of appropriate social behavior. However, the neural substrates underlying social reward processing and how they might differ based on the sex and internal state…
View article: Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning
Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning Open
How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens, which is implicated in this process, receives glutamatergic inputs from the prelimbic cortex and midline regions of the thalamus. However, little is k…
View article: Choice-selective sequences dominate in cortical relative to thalamic inputs to nucleus accumbens, providing a potential substrate for credit assignment
Choice-selective sequences dominate in cortical relative to thalamic inputs to nucleus accumbens, providing a potential substrate for credit assignment Open
How are actions linked with subsequent outcomes to guide choices? The nucleus accumbens, which is implicated in this process, receives glutamatergic inputs from the prelimbic cortex and midline regions of the thalamus. However, little is k…
View article: Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences
Focal expression of mutant huntingtin in the songbird basal ganglia disrupts cortico-basal ganglia networks and vocal sequences Open
Significance Genetic mutations that impair basal ganglia (BG) function affect sequential movements, but the link between genotype, BG circuit dysfunction, and altered behavior remains unclear. Here, we found that viral expression of a gene…