Malcolm E. Legget
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View article: Lipoprotein(a) concentrations and secondary outcomes following first-time acute coronary syndrome: The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS)
Lipoprotein(a) concentrations and secondary outcomes following first-time acute coronary syndrome: The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS) Open
Elevated Lp(a) concentrations are associated with secondary events following ACS. Further research is needed to define optimal thresholds for increased risk and explore ethnic-specific implications for secondary prevention.
View article: The Prognostic Value of Cardiac Troponin in a Revascularized Cohort with First-Time Myocardial Infarction
The Prognostic Value of Cardiac Troponin in a Revascularized Cohort with First-Time Myocardial Infarction Open
Introduction: The prognostic value of cardiac troponins in revascularized patients with myocardial infarction (MI) is uncertain. This study examined the relationship between peak troponin levels and adverse outcomes in a revascularized coh…
View article: Dietary patterns of patients with acute coronary syndrome in the multi-ethnic New Zealand study of acute coronary syndromes (MENZACS)
Dietary patterns of patients with acute coronary syndrome in the multi-ethnic New Zealand study of acute coronary syndromes (MENZACS) Open
Three distinct dietary patterns were found in patients presenting with first-time ACS in NZ and these patterns were associated with various socio-demographic and clinical factors.
View article: A standards-based software tool to support prognostic modelling: application to exemplar heart failure risk scores
A standards-based software tool to support prognostic modelling: application to exemplar heart failure risk scores Open
Introduction Heart failure prognosis is an active research area, with the development of several new risk scores each year. While risk score derivation and evaluation have become common practices, these processes currently lack standardisa…
View article: DNA methylation in the TXNIP gene is associated with type 2 diabetes in Pacific Peoples living in NZ
DNA methylation in the TXNIP gene is associated with type 2 diabetes in Pacific Peoples living in NZ Open
Background Pacific Peoples living in Aotearoa New Zealand (NZ) have higher rates of type 2 diabetes (T2D) and have benefited less from improvements in cardiovascular health outcomes when compared with other populations in NZ. DNA methylati…
View article: Correcting bias in cardiac geometries derived from multimodal images using spatiotemporal mapping
Correcting bias in cardiac geometries derived from multimodal images using spatiotemporal mapping Open
Cardiovascular imaging studies provide a multitude of structural and functional data to better understand disease mechanisms. While pooling data across studies enables more powerful and broader applications, performing quantitative compari…
View article: MITEA: A dataset for machine learning segmentation of the left ventricle in 3D echocardiography using subject-specific labels from cardiac magnetic resonance imaging
MITEA: A dataset for machine learning segmentation of the left ventricle in 3D echocardiography using subject-specific labels from cardiac magnetic resonance imaging Open
Segmentation of the left ventricle (LV) in echocardiography is an important task for the quantification of volume and mass in heart disease. Continuing advances in echocardiography have extended imaging capabilities into the 3D domain, sub…
View article: An automated method for BRISQUE quantification of image quality in echocardiography
An automated method for BRISQUE quantification of image quality in echocardiography Open
Background Echocardiography (echo) remains the most widely used imaging modality for the assessment, monitoring, and prognostication of the heart. Despite its prevalence, standardisation efforts for echo chamber quantification are ongoing,…
View article: An automated method for BRISQUE quantification of image quality in echocardiography
An automated method for BRISQUE quantification of image quality in echocardiography Open
Background Echocardiography (echo) remains the most widely used imaging modality for the assessment, monitoring, and prognostication of the heart. Despite its prevalence, standardisation efforts for echo chamber quantification are ongoing,…
View article: Right ventricular quantification using 3D echocardiography: a comparison with CMR
Right ventricular quantification using 3D echocardiography: a comparison with CMR Open
Background Volumetric and functional right ventricular (RV) indices such as ejection fraction (EF) and global strains are known independent predictors of adverse cardiovascular events. While cardiac magnetic resonance (CMR) imaging remains…
View article: Derivation of in vivo pressure-volume loops for post-heart transplant patients using real-time 3D echocardiography and left ventricular catheterisation
Derivation of in vivo pressure-volume loops for post-heart transplant patients using real-time 3D echocardiography and left ventricular catheterisation Open
Background Image-based methods that combine catheterisation with non-concurrent cardiac magnetic resonance (CMR) imaging data and echocardiography (echo) is gaining more interest than the conductance catheter method to derive pressure-volu…
View article: Longitudinal strain measurement by 3D modelling from cine CMR: feasibility and comparison to 2D speckle tracking echocardiography
Longitudinal strain measurement by 3D modelling from cine CMR: feasibility and comparison to 2D speckle tracking echocardiography Open
Background Global longitudinal strain (GLS) has emerged as a sensitive index of left ventricular (LV) systolic function with greater prognostic value than LV ejection fraction (LVEF) in a variety of cardiac disorders. While GLS is routinel…
View article: Systematic Comparison of Left Ventricular Geometry Between 3D-Echocardiography and Cardiac Magnetic Resonance Imaging
Systematic Comparison of Left Ventricular Geometry Between 3D-Echocardiography and Cardiac Magnetic Resonance Imaging Open
Aims: Left ventricular (LV) volumes estimated using three-dimensional echocardiography (3D-echo) have been reported to be smaller than those measured using cardiac magnetic resonance (CMR) imaging, but the underlying causes are not well-un…
View article: 960Dietary intakes of patients with first Acute Coronary Syndrome: the MENZACS study
960Dietary intakes of patients with first Acute Coronary Syndrome: the MENZACS study Open
Background In New Zealand (NZ) approximately 10,000 people experience an acute coronary syndrome (ACS) annually. Little is known about the diets of people who present with first ACS. Methods The Multi-Ethnic NZ study of Acute Coronary Synd…
View article: The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology
The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS): Design and Methodology Open
Background. Each year, approximately 5000 New Zealanders are admitted to hospital with first-time acute coronary syndrome (ACS). The Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS) is a prospective longitudinal cohort …
View article: Automated analysis of 3D-echocardiography using spatially registered patient-specific CMR meshes
Automated analysis of 3D-echocardiography using spatially registered patient-specific CMR meshes Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Heart Foundation (NHF) of New Zealand Health Research Council (HRC) of New Zealand Artificial intelligence shows con…