Malcolm Horne
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Effects of rotigotine on sleep in Parkinson’s disease patients: a Parkinson’s KinetiGraph study Open
Introduction Recent studies suggest that the dopamine agonist (DA) rotigotine improves sleep among Parkinson disease (PD) patients. Parkinson’s KinetiGraph (PKG) offers a home-based alternative for evaluating sleep. We investigated the eff…
Alpha-synuclein is increased in erythrocytes in Parkinson’s Disease cases Open
Idiopathic Parkinson’s disease (iPD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). Mutations in the SCNA gene, which encodes the protein alpha synuclein (α-syn), are associated with familial forms of P…
Goal‐Directed Rehabilitation Versus Standard Care for Individuals with Hereditary Cerebellar Ataxia: A Multicenter, Single‐Blind, Randomized Controlled Superiority Trial Open
Objective Rehabilitation is thought to reduce ataxia severity in individuals with hereditary cerebellar ataxia (HCA). This multicenter, randomized controlled superiority trial aimed to examine the efficacy of a 30‐week goal‐directed rehabi…
At-Home Blood Pressure Measurements Provide Better Assessments of Orthostatic Hypotension in Parkinson’s Disease Open
Orthostatic hypotension (OH) is common in Parkinson’s Disease (PD). It is intermittent, exacerbated by stressors including meals, medications, and dehydration, and frequently is unrecognized. Although intermittent, assessment is usually by…
Machine Learning-Based Scoring System to Predict the Risk and Severity of Ataxic Speech Using Different Speech Tasks Open
The assessment of speech in Cerebellar Ataxia (CA) is time-consuming and requires clinical interpretation. In this study, we introduce a fully automated objective algorithm that uses significant acoustic features from time, spectral, cepst…
View article: Technological Evolution in the Instrumentation of Ataxia Severity Measurement
Technological Evolution in the Instrumentation of Ataxia Severity Measurement Open
Cerebellar ataxia is the poorly coordinated movement that results from injury or disease affecting the cerebellum. The diagnosis and assessment of ataxia are significantly challenging due to dependency on clinicians’ experience and the att…
Measurement of bradykinesia and chorea in Huntington's Disease using ambulatory monitoring Open
Measures of bradykinesia and dyskinesia from clinical scales have acceptable correlations with those from the PKG. Continuous monitoring provides information about daytime sleep, which was associated with lower functional status. Further s…
Accuracy of Step Count Estimations in Parkinson’s Disease Can Be Predicted Using Ambulatory Monitoring Open
Objectives There are concerns regarding the accuracy of step count in Parkinson’s disease (PD) when wearable sensors are used. In this study, it was predicted that providing the normal rhythmicity of walking was maintained, the autocorrela…
Sensor Measurements Can Characterize Fluctuations and Wearing Off in Parkinson’s Disease and Guide Therapy to Improve Motor, Non-motor and Quality of Life Scores Open
Objectives The aim was to examine the role of sensor measurement in identifying and managing fluctuations in bradykinesia of Parkinson’s Disease. Method Clinical scales and data from wearable sensors obtained before and after optimization …
Changes in the Gut Microbiome and Predicted Functional Metabolic Effects in an Australian Parkinson’s Disease Cohort Open
Background: There has been increasing recognition of the importance of the gut microbiome in Parkinson’s disease (PD), but the influence of geographic location has received little attention. The present study characterized the gut microbio…
Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson’s Disease Open
Introduction Cholesterol levels have been associated with age-related cognitive decline, however, such an association has not been comprehensively explored in people with Parkinson’s disease (PD). To address this uncertainty, the current c…
A Method for Measuring Time Spent in Bradykinesia and Dyskinesia in People With Parkinson’s Disease Using an Ambulatory Monitor Open
BackgroundFluctuations in motor function in Parkinson’s Disease (PD) are frequent and cause significant disability. Frequently device assisted therapies are required to treat them. Currently, fluctuations are self-reported through diaries …
Modeling the Progression of Speech Deficits in Cerebellar Ataxia Using a Mixture Mixed-Effect Machine Learning Framework Open
Background: Accurate and reliable prediction of changes in the severity of cerebellar ataxia (CA) will be necessary for trials of disease-modifying therapies. Cerebellar dysarthria (CD) is a common feature of CA. This study demonstrated th…
Objective Assessment of Progression and Disease Characterization of Friedreich Ataxia via an Instrumented Drinking Cup: Preliminary Results Open
The monitoring of disease progression in certain neurodegenerative conditions can significantly be quantified with the help of objective assessments. The severity assessment of diseases like Friedreich ataxia (FRDA) are usually based on di…
A blinded, controlled trial of objective measurement in Parkinson’s disease Open
Medical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson’s disease has effective therapies, but continuous objective measurement has only recently become available. This …
A Comprehensive Scheme for the Objective Upper Body Assessments of Subjects with Cerebellar Ataxia Open
BackgroundCerebellar Ataxia refers to the disturbance in movement resulting from cerebellar dysfunction. It manifests as inaccurate movements with delayed onset and overshoot, especially when movements are repetitive or rhythmic. Identific…
A Comprehensive Scheme for the Objective Upper Body Assessments of Subjects with Cerebellar Ataxia Open
Background Cerebellar ataxia (CA) is a complex motor disorder that exhibits various symptoms such as lack of movement accuracy, delayed motion and ataxic movements associated with gait, extremity and eye. Accurate assessment of ataxic move…
Khodakarami, H., et al., Prediction of the Levodopa Challenge Test in Parkinson’s Disease Using Data from a Wrist-Worn Sensor. Sensors 2019, 19, 5153 Open
The authors wish to make the following erratum to this paper [...]
Objective measurement in Parkinson’s disease: a descriptive analysis of Parkinson’s symptom scores from a large population of patients across the world using the Personal KinetiGraph® Open
Background The Personal KinetiGraph® (PKG®) Movement Recording System provides continuous, objective, ambulatory movement data during routine daily activities and provides information on medication compliance, motor fluctuations, immobilit…
The Latent-Variable Structure of the Addenbrooke’s Cognitive Examination-Revised Open
Objectives To establish a theoretically justified factor structure for the Addenbrooke’s Cognitive Examination-Revised (ACE-R). Methods Our sample comprised 288 patients with Parkinson’s disease (179 men and 109 women). The mean age of par…
Prediction of the Levodopa Challenge Test in Parkinson’s Disease Using Data from a Wrist-Worn Sensor Open
The response to levodopa (LR) is important for managing Parkinson’s Disease and is measured with clinical scales prior to (OFF) and after (ON) levodopa. The aim of this study was to ascertain whether an ambulatory wearable device could pre…
Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort Open
Introduction . Patients with Parkinson’s disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. T…
The Use of Data from the Parkinson’s KinetiGraph to Identify Potential Candidates for Device Assisted Therapies Open
Device-assisted therapies (DAT) benefit people with Parkinsons Disease (PwP) but many referrals for DAT are unsuitable or too late, and a screening tool to aid in identifying candidates would be helpful. This study aimed to produce such a …