Malcolm Kohler
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View article: Correlation between acute cellular rejection detected with cryobiopsy and elevated dd-cfDNA in lung transplant recipients
Correlation between acute cellular rejection detected with cryobiopsy and elevated dd-cfDNA in lung transplant recipients Open
Introduction: Donor-derived cell-free DNA (dd-cfDNA) may be a promising biomarker for detecting acute cellular rejection (ACR) in lung transplant recipients (LTR) without the need for invasive transbronchial biopsies. We aimed to validate …
View article: Correlation between acute cellular rejection detected with cryobiopsy and elevated donor-derived cell-free DNA in lung transplant recipients
Correlation between acute cellular rejection detected with cryobiopsy and elevated donor-derived cell-free DNA in lung transplant recipients Open
Introduction: Donor-derived cell-free DNA (dd-cfDNA) may be a promising biomarker for detecting acute cellular rejection (ACR) in lung transplant recipients (LTR) without the need for invasive transbronchial biopsies. We aimed to validate …
View article: Acute COPD exacerbation despite triple inhaled therapy: a molecular insight – TripleEx study
Acute COPD exacerbation despite triple inhaled therapy: a molecular insight – TripleEx study Open
ClinicalTrials.gov (NCT04638920), registered on 20.11.2020.
View article: Bicarbonate from arterial blood gas analysis as predictor of sleep-related hypoventilation: a diagnostic accuracy study
Bicarbonate from arterial blood gas analysis as predictor of sleep-related hypoventilation: a diagnostic accuracy study Open
Background Bicarbonate above the upper limit of normal is used as an indicator of sleep-related hypoventilation in patients with diseases frequently associated with hypoventilation, such as obesity or neuromuscular diseases. Research quest…
View article: Exploring breath metabolomics as a non-invasive tool for detecting pulmonary vascular disease
Exploring breath metabolomics as a non-invasive tool for detecting pulmonary vascular disease Open
Aims The aim of this initial study was to explore whether prediction models based on breath metabolome profiles could detect differences between pulmonary vascular disease (PVD) patients and healthy controls. Additionally, we sought to inv…
View article: Diagnosis of Peripheral Pulmonary Lesions Using Forceps and 1.1- or 1.7-mm Cryoprobes: A Randomised Trial
Diagnosis of Peripheral Pulmonary Lesions Using Forceps and 1.1- or 1.7-mm Cryoprobes: A Randomised Trial Open
Introduction: Lung cancer screening has increased the detection of peripheral pulmonary lesions (PPLs). Accurate diagnosis for therapy and prognosis is crucial but challenging. Our study compares the safety and efficacy of transbronchial c…
View article: Molecular breath profile of acute COPD exacerbations
Molecular breath profile of acute COPD exacerbations Open
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) show high variability in individual susceptibility and promote disease progression; thus, accurate diagnosis and treatment is essential. Unravelling the molecular metabo…
View article: The Swiss Prison Study (SWIPS): Results from a registry-based study of prisoners in Switzerland from 2015 to 2020
The Swiss Prison Study (SWIPS): Results from a registry-based study of prisoners in Switzerland from 2015 to 2020 Open
AIM OF THE STUDY: The purpose of the present study was to evaluate demographic characteristics of inmates in the Canton of Zurich (exposure), and investigate the changes in diseases and drug use between 2015 and 2020 (outcome). METHODS: Th…
View article: Efficacy of surveillance bronchoscopy<i>versus</i>clinically indicated bronchoscopy for detection of acute lung transplant rejection: a systematic review and meta-analysis
Efficacy of surveillance bronchoscopy<i>versus</i>clinically indicated bronchoscopy for detection of acute lung transplant rejection: a systematic review and meta-analysis Open
Background Acute allograft rejection after lung transplantation significantly increases the risk of developing bronchiolitis obliterans syndrome, a form of chronic lung allograft dysfunction and the leading cause of mortality beyond the in…
View article: Exhaled breath analysis in patients with potentially curative lung cancer undergoing surgery: a longitudinal study
Exhaled breath analysis in patients with potentially curative lung cancer undergoing surgery: a longitudinal study Open
Exhaled breath analysis has emerged as a non-invasive and promising method for early detection of lung cancer, offering a novel approach for diagnosis through the identification of specific biomarkers present in a patient’s breath. For thi…
View article: Submaximal, Low-Dose Eccentric vs Traditional Cycling Exercise: Reduced Oxygen Uptake and Pulmonary Artery Pressure Assessed by Echocardiography in Healthy Middle-aged Adults. A Randomized Controlled, Crossover Trial
Submaximal, Low-Dose Eccentric vs Traditional Cycling Exercise: Reduced Oxygen Uptake and Pulmonary Artery Pressure Assessed by Echocardiography in Healthy Middle-aged Adults. A Randomized Controlled, Crossover Trial Open
ECC was well tolerated, and significant reductions were observed in V'O2, ventilation, and right ventricular load compared with CON, even at low intensity levels. This study, conducted on healthy middle-aged participants, did not raise con…
View article: Clinical characteristics governing treatment adjustment in COPD patients: results from the Swiss COPD cohort study
Clinical characteristics governing treatment adjustment in COPD patients: results from the Swiss COPD cohort study Open
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a widespread chronic disease characterised by irreversible airway obstruction [1]. Features of clinical practice and healthcare systems for COPD patients can vary widely, even wit…
View article: Risk Factors for Recurrent Exacerbations in the General-Practitioner-Based Swiss Chronic Obstructive Pulmonary Disease (COPD) Cohort
Risk Factors for Recurrent Exacerbations in the General-Practitioner-Based Swiss Chronic Obstructive Pulmonary Disease (COPD) Cohort Open
Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer from acute exacerbations. Our objective was to describe recurrent exacerbations in a GP-based Swiss COPD cohort and develop a statistical model for predict…
View article: Adherence to the GOLD Guidelines in Primary Care: Data from the Swiss COPD Cohort
Adherence to the GOLD Guidelines in Primary Care: Data from the Swiss COPD Cohort Open
(1) Introduction: Chronic obstructive pulmonary disease (COPD) and its associated morbidity and mortality are a global burden on both affected patients and healthcare systems. The Global Initiative for Chronic Obstructive Lung Disease (GOL…
View article: Effects of CPAP therapy on molecular breath pattern in newly diagnosed OSA
Effects of CPAP therapy on molecular breath pattern in newly diagnosed OSA Open
Introduction: Although OSA is considered a major public health issue, metabolic consequences of different OSA phenotypes are still unknown. Previous studies using breath analysis to evaluate metabolic consequences of OSA suggested disease …
View article: Effects of continuous positive airway pressure therapy on glucose metabolism in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis
Effects of continuous positive airway pressure therapy on glucose metabolism in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis Open
Obstructive sleep apnoea is a highly prevalent chronic disorder and has been shown to be associated with disturbed glucose metabolism and type 2 diabetes. However, the evidence from individual clinical trials on the effect of continuous po…
View article: Cardiomyopathy as cause of death in Duchenne muscular dystrophy: a longitudinal observational study
Cardiomyopathy as cause of death in Duchenne muscular dystrophy: a longitudinal observational study Open
Background Cardiomyopathy has become an important life-limiting factor since survival in Duchenne muscular dystrophy (DMD) has greatly increased with long-term ventilation and cough assistance. The aim of this study was to investigate the …
View article: Physical Health-Related Quality of Life Improves over Time in Post-COVID-19 Patients: An Exploratory Prospective Study
Physical Health-Related Quality of Life Improves over Time in Post-COVID-19 Patients: An Exploratory Prospective Study Open
(1) Background: Ongoing symptoms after mild or moderate acute coronavirus disease 19 (COVID-19) substantially affect health-related quality of life (HRQoL). However, follow-up data on HRQoL are scarce. We characterized the change in HRQoL …
View article: Bedtime to the brain: how infants’ sleep behaviours intertwine with non‐rapid eye movement sleep electroencephalography features
Bedtime to the brain: how infants’ sleep behaviours intertwine with non‐rapid eye movement sleep electroencephalography features Open
Summary Adequate sleep is critical for development and facilitates the maturation of the neurophysiological circuitries at the basis of cognitive and behavioural function. Observational research has associated early life sleep problems wit…
View article: The effect of longitudinal sleep monitoring on clinician agreement in obstructive sleep apnea diagnosis: The <scp>ELSA</scp> study
The effect of longitudinal sleep monitoring on clinician agreement in obstructive sleep apnea diagnosis: The <span>ELSA</span> study Open
Summary There is strong evidence for clinically relevant night‐to‐night variability of respiratory events in patients with suspected obstructive sleep apnea. Sleep experts retrospectively evaluated diagnostic data in 56 patients with suspe…
View article: Chest CT Findings after Mild COVID-19 Do Not Explain Persisting Respiratory Symptoms: An Explanatory Study
Chest CT Findings after Mild COVID-19 Do Not Explain Persisting Respiratory Symptoms: An Explanatory Study Open
(1) Background: Lung tissue involvement is frequently observed in acute COVID-19. However, it is unclear whether CT findings at follow-up are associated with persisting respiratory symptoms after initial mild or moderate infection. (2) Met…
View article: Online breath analysis with SESI/HRMS for metabolic signatures in children with allergic asthma
Online breath analysis with SESI/HRMS for metabolic signatures in children with allergic asthma Open
Introduction: There is a need to improve the diagnosis and management of pediatric asthma. Breath analysis aims to address this by non-invasively assessing altered metabolism and disease-associated processes. Our goal was to identify exhal…