Malcolm Tan
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View article: Early predictors of rescue therapy and colectomy in acute severe ulcerative colitis
Early predictors of rescue therapy and colectomy in acute severe ulcerative colitis Open
Introduction: Acute severe ulcerative colitis (ASUC) is a significant cause of disease morbidity. One-third of patients with ASUC are steroid refractory. Rescue therapy may not successfully induce remission, necessitating colectomy. We aim…
View article: Open-Access Oesophagogastroduodenoscopy as an Effective and Safe Strategy for Patients With Non-alarming Symptoms
Open-Access Oesophagogastroduodenoscopy as an Effective and Safe Strategy for Patients With Non-alarming Symptoms Open
OAO is a safe and effective strategy for providing timely diagnostic OGD to normal-risk patients at our center. Primary care physicians are encouraged to refer non-alarming dyspepsia symptoms patients under 60 years for OAO over the conven…
View article: Approximately 1 in 10 ambulatory inflammatory bowel disease patients are at risk of malnutrition: A prospective Singapore cohort
Approximately 1 in 10 ambulatory inflammatory bowel disease patients are at risk of malnutrition: A prospective Singapore cohort Open
Objectives Prevalence of malnutrition among ambulatory inflammatory bowel disease (IBD) patients in Singapore is unknown. We aimed to evaluate the prevalence of ambulatory IBD patients at risk of malnutrition (ARMN) using Malnutrition Univ…
View article: Favorable vaccine-induced SARS-CoV-2–specific T cell response profile in patients undergoing immune-modifying therapies
Favorable vaccine-induced SARS-CoV-2–specific T cell response profile in patients undergoing immune-modifying therapies Open
BACKGROUNDPatients undergoing immune-modifying therapies demonstrate a reduced humoral response after COVID-19 vaccination, but we lack a proper evaluation of the effect of such therapies on vaccine-induced T cell responses.METHODSWe longi…
View article: Favourable vaccine-induced SARS-CoV-2 specific T cell response profile in patients undergoing immune-modifying therapies
Favourable vaccine-induced SARS-CoV-2 specific T cell response profile in patients undergoing immune-modifying therapies Open
Patients undergoing immune-modifying therapies demonstrate a reduced humoral response after COVID-19 vaccination, but we lack a proper evaluation of the impact of such therapies on vaccine-induced T cell responses. Here, we longitudinally …
View article: Ulcerative colitis: STRIDE-ing beyond symptoms with new standards
Ulcerative colitis: STRIDE-ing beyond symptoms with new standards Open
The landscape of ulcerative colitis has changed in the last two decades. Advancements in pharmacotherapeutics have heralded the introduction of new treatment options, with many agents in development. Better clinical outcomes are seen with …
View article: Clinical audit of current Helicobacter pylori treatment outcomes in Singapore
Clinical audit of current Helicobacter pylori treatment outcomes in Singapore Open
Introduction: H. pylori eradication reduces the risk of gastric malignancies and peptic ulcer disease. First-line therapies include 14-day PAC (proton pump inhibitor [PPI], amoxicillin, clarithromycin) and PBMT (PPI, bismuth, metronidazole…
View article: 486 Spontaneous haemoperitoneum due to acute hemorrhagic pancreatitis in a child: A Case report
486 Spontaneous haemoperitoneum due to acute hemorrhagic pancreatitis in a child: A Case report Open
Introduction Hemoperitoneum resulting from acute pancreatitis (AP) is rare. It is more commonly associated with chronic pancreatitis. Seldom, it has been associated with paediatric population. Here we report a case of spontaneous hemoperit…
View article: Clinical Features and Predictors of Dysplasia in Proximal Sessile Serrated Lesions
Clinical Features and Predictors of Dysplasia in Proximal Sessile Serrated Lesions Open
Background/Aims: Proximal colorectal cancers (CRCs) account for up to half of CRCs. Sessile serrated lesions (SSLs) are precursors to CRC. Proximal location and presence of dysplasia in SSLs predict higher risks of progression to cancer. T…
View article: Impact of enhanced personal protective equipment on colonoscopy performance during the COVID-19 pandemic
Impact of enhanced personal protective equipment on colonoscopy performance during the COVID-19 pandemic Open
Background and study aims Using personal protective equipment (PPE) can reduce risk of disease transmission. During the COVID-19 pandemic, enhanced PPE (EPPE) is recommended when performing endoscopy. We aimed to evaluate the impact of EPP…
View article: A prospective randomized study of colonoscopy using blue laser imaging and white light imaging in detection and differentiation of colonic polyps
A prospective randomized study of colonoscopy using blue laser imaging and white light imaging in detection and differentiation of colonic polyps Open
Background and study aims Published data on blue laser imaging (BLI) for detection and differentiation of colonic polyps are limited compared to narrow band imaging (NBI). This study investigated whether BLI can increase the detection rate…
View article: Endosonographic Appearances of a Rare Duodenal Tumour, Brunner’s Gland Hamartoma
Endosonographic Appearances of a Rare Duodenal Tumour, Brunner’s Gland Hamartoma Open
Brunner’s gland hamartoma (BGH) is a rare sub-epithelial tumour of the duodenum, which may cause haemorrhagic or obstructive gastrointestinal symptoms. Their accurate histological diagnosis often remains elusive before resection. Although …
View article: Massive upper gastrointestinal bleeding post-Whipple’s surgery from anastomotic varices due to mesenteric hypertension
Massive upper gastrointestinal bleeding post-Whipple’s surgery from anastomotic varices due to mesenteric hypertension Open
A 45-year-old man was admitted with hematemesis. He had undergone Whipple's surgery 7 years previously for a 5-cm serous cystadenoma of the pancreatic head. Upon presentation, he was hypotensive (blood pressure 82/59 mmHg) and tachycardic …