Malik Saadullah
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View article: Distachionate and Its Nanocomposites Modulate Oxidative Stress, Inflammation, and Diabetes-Related Genes in High-Fructose/Streptozotocin Model
Distachionate and Its Nanocomposites Modulate Oxidative Stress, Inflammation, and Diabetes-Related Genes in High-Fructose/Streptozotocin Model Open
Medicinal plants, known for their bioactive compounds, have long been utilized for the treatment of various diseases, including diabetes. A novel compound, distachionate (DST), was isolated as a yellowish powder from Breynia disticha
View article: Isolation And Characterization Of A Novel Chalcone Derivative From Arisaema Utile A Selective MAO-B Inhibitor In Sodium Azide-Induced Rat Model
Isolation And Characterization Of A Novel Chalcone Derivative From Arisaema Utile A Selective MAO-B Inhibitor In Sodium Azide-Induced Rat Model Open
This study aims to investigate the neuroprotective effects of Utilito, a novel chalcone derivative isolated from Arisaema utile in a sodium azide-induced Alzheimer’s disease (AD) rat model. Anti-alzheimer activities were assessed through i…
View article: Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson’s disease model through the modulation of neuroinflammatory markers
Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson’s disease model through the modulation of neuroinflammatory markers Open
The plant Cissus tuberosa Moc is abundant in phenolics, has been documented to have neuroprotective properties. The study seeks to determine the neuroprotective effects of C . tuberosa ethanolic extract (CTE) against Parkinson’s disease by…
View article: Quantitative analysis of loxoprofen sodium loaded microspheres comprising pectin and its thiolated conjugates: In-vivo evaluation of their sustained release behavior
Quantitative analysis of loxoprofen sodium loaded microspheres comprising pectin and its thiolated conjugates: In-vivo evaluation of their sustained release behavior Open
View article: Isatin-based ibuprofen and mefenamic acid Schiff base derivatives as dual inhibitors against urease and α–glucosidase: In vitro, in silico and cytotoxicity studies
Isatin-based ibuprofen and mefenamic acid Schiff base derivatives as dual inhibitors against urease and α–glucosidase: In vitro, in silico and cytotoxicity studies Open
α-Glucosidase and urease inhibitors have emerged as crucial for developing therapeutic drugs targeting diabetes and gastrointestinal disorders. This study reports on new series of ibuprofen and mefenamic acid Schiff base derivatives incorp…
View article: Synthesis and Characterization of Chemically and Green-Synthesized Silver Oxide Particles for Evaluation of Antiviral and Anticancer Activity
Synthesis and Characterization of Chemically and Green-Synthesized Silver Oxide Particles for Evaluation of Antiviral and Anticancer Activity Open
Silver oxide (Ag2O) particles are wonderful candidates due to their unique properties, and their use in a wide range of research, industrial and biomedical applications is rapidly increasing. This makes it fundamental to develop simple, en…
View article: Appraisal of the anti-arthritic potential of Strelitzia reginae inWistar rats via modulating molecular inflammatory cascadesIL-6,IL-17a, IL-1β,TNF-α, IFN-γ, RANKL, OPG, and IL-4 and attenuating oxidative stress biomarkers
Appraisal of the anti-arthritic potential of Strelitzia reginae inWistar rats via modulating molecular inflammatory cascadesIL-6,IL-17a, IL-1β,TNF-α, IFN-γ, RANKL, OPG, and IL-4 and attenuating oxidative stress biomarkers Open
The study aimed to investigate the potential anti-arthritic effects of methanolic aerial extract of the plant Strelitzia reginae (MSRA), because of its potential anti-arthritic effects.The research utilised Wistar albino rats, and all grou…
View article: Biochemical properties and biological potential of Syzygium heyneanum with antiparkinson’s activity in paraquat induced rodent model
Biochemical properties and biological potential of Syzygium heyneanum with antiparkinson’s activity in paraquat induced rodent model Open
Syzygium heyneanum is a valuable source of flavonoids and phenols, known for their antioxidant and neuroprotective properties. This research aimed to explore the potential of Syzygium heyneanum ethanol extract (SHE) in countering Parkinson…
View article: Biological and in silico investigation of isolated novel bioactive compound from Conocarpus lancifolius
Biological and in silico investigation of isolated novel bioactive compound from Conocarpus lancifolius Open
The plant Conocarpus lancifolius from Combertaceae family, has been documented to have strong medicinal potential. The objective of this research was to determine antioxidant, anti-inflammatory, and cytotoxic potential of C. lancifolius by…
View article: Antitumor activity of zinc oxide nanoparticles fused with green extract of Nigella sativa
Antitumor activity of zinc oxide nanoparticles fused with green extract of Nigella sativa Open
Zinc oxide nanoparticles have attracted considerable attention as promising candidates in various fields, especially in the realm of medical science. In the present experimental study, the co-precipitation method was used to synthesize che…
View article: Phytochemical and biological studies of Panicum antidotale aerial parts ethanol extract supported by molecular docking study
Phytochemical and biological studies of Panicum antidotale aerial parts ethanol extract supported by molecular docking study Open
Panicum antidotale has traditionally been used as a poultice to alleviate local inflammation and painful diseases. This study aimed to evaluate the anti-inflammatory, wound-healing, analgesic, and antipyretic potential of its ethanol extra…
View article: Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate
Development and Pharmacokinetic Evaluation of Novasomes for the Trans-nasal Delivery of Fluvoxamine Using Arachidonic Acid-Carboxymethyl Chitosan Conjugate Open
Depression is the major mental illness which causes along with loss of interest in daily life, a feeling of hopelessness, appetite or weight changes, anger and irritability. Due to the hepatic first-pass metabolism, the absolute bioavailab…
View article: Fabrication, Characterization and Biomedical Evaluation of a Statistically Optimized Gelatin Scaffold Enriched with Co-Drugs Loaded into Controlled-Release Silica Nanoparticles
Fabrication, Characterization and Biomedical Evaluation of a Statistically Optimized Gelatin Scaffold Enriched with Co-Drugs Loaded into Controlled-Release Silica Nanoparticles Open
The current study focused on the fabrication of a well-designed, biocompatible, physically stable, non-irritating and highly porous gelatin scaffold loaded with controlled-release triamcinolone acetonide (TA) and econazole nitrate (EN) co-…
View article: Evaluation of molecular mechanisms responsible for in vivo anti-Alzheimer’s property of Euphorbia cotinifolia methanol extract
Evaluation of molecular mechanisms responsible for in vivo anti-Alzheimer’s property of Euphorbia cotinifolia methanol extract Open
Alzheimer's is considered as the most prevalent neurological disease; it is a degenerative and progressive disease that affects brain’s neurons causing memory, language and thinking loss, as well as behavioral abnormalities. This study was…
View article: Antibacterial Efficacy of N-(4-methylpyridin-2-yl) Thiophene-2-Carboxamide Analogues against Extended-Spectrum-β-Lactamase Producing Clinical Strain of Escherichia coli ST 131
Antibacterial Efficacy of N-(4-methylpyridin-2-yl) Thiophene-2-Carboxamide Analogues against Extended-Spectrum-β-Lactamase Producing Clinical Strain of Escherichia coli ST 131 Open
Development in the fields of natural-product-derived and synthetic small molecules is in stark contrast to the ongoing demand for novel antimicrobials to treat life-threatening infections caused by extended-spectrum β-lactamase producing E…
View article: Comparative evaluation of ethyl acetate and n‐Hexane extracts of <i>Cannabis sativa</i> L. leaves for muscle function restoration after peripheral nerve lesion
Comparative evaluation of ethyl acetate and n‐Hexane extracts of <i>Cannabis sativa</i> L. leaves for muscle function restoration after peripheral nerve lesion Open
Peripheral nerve injuries are one of those complex medical conditions for which a highly effective first‐line treatment is currently missing. The use of natural compound as medicines to treat various disorders has a long history. Our previ…
View article: Cytotoxic and Antioxidant Activities, and Phytochemical Analysis of Methanol Extract of Euphorbia cotinifolia
Cytotoxic and Antioxidant Activities, and Phytochemical Analysis of Methanol Extract of Euphorbia cotinifolia Open
Background: Plants contain complex and structurally different phytochemicals. The popularity of herbal medicinal products for a variety of disorders in recent years has prompted researchers to study the therapeutic activities of several me…
View article: Correction to Therapeutic Potential of Standardized Extract of <i>Melilotus indicus</i> (L.) All. and Its Phytochemicals against Skin Cancer in Animal Model: <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Studies
Correction to Therapeutic Potential of Standardized Extract of <i>Melilotus indicus</i> (L.) All. and Its Phytochemicals against Skin Cancer in Animal Model: <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Studies Open
[This corrects the article DOI: 10.1021/acsomega.2c03053.].
View article: Synthesis, Characterization, and Application of BaTiO3 Nanoparticles for Anti-Cancer Activity
Synthesis, Characterization, and Application of BaTiO3 Nanoparticles for Anti-Cancer Activity Open
Barium titanate (BaTiO 3 ) nanoparticles (BTNPs) have been considered as emerging materials in biomedical sector through last decades due to the excellent physicochemical properties such as dielectric and piezoelectric structures, biocompa…
View article: Molecular Modeling Study of Novel Lancifolamide Bioactive Molecule as an Inhibitor of Acetylcholinesterase (AChE), Herpes Simplex Virus (HSV-1), and Anti-proliferative Proteins
Molecular Modeling Study of Novel Lancifolamide Bioactive Molecule as an Inhibitor of Acetylcholinesterase (AChE), Herpes Simplex Virus (HSV-1), and Anti-proliferative Proteins Open
Combretaceae, an immense family involving species (500) or genera (20), originates in tropical and subtropical regions. This family has evinced medicinal values such as anti-leishmanial, cytotoxic, antibacterial, antidiabetic, antiprotozoa…
View article: Therapeutic Potential of Standardized Extract of <i>Melilotus indicus</i> (L.) All. and Its Phytochemicals against Skin Cancer in Animal Model: <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Studies
Therapeutic Potential of Standardized Extract of <i>Melilotus indicus</i> (L.) All. and Its Phytochemicals against Skin Cancer in Animal Model: <i>In Vitro</i>, <i>In Vivo</i>, and <i>In Silico</i> Studies Open
[Image: see text] Melilotus indicus (L.) All. is known to have anti-inflammatory and anticancer properties. The present study explored the in vivo skin carcinogenesis attenuating potential of ethanolic extract of M. indicus (L.) All. (Miet…
View article: Nanoparticles of thiolated chitosan for controlled delivery of moxifloxacin: In-vitro and in-vivo evaluation
Nanoparticles of thiolated chitosan for controlled delivery of moxifloxacin: In-vitro and in-vivo evaluation Open
Controlled release drug delivery system of moxifloxacin produces better therapeutic effects and maintain the plasma concentration for prolong period of time. The objective of this work was to formulate nanoparticles of thiolated chitosan (…
View article: Dose Dependent Effects of <i>Breynia cernua</i> Against the Paraquat Induced Parkinsonism like Symptoms in Animals’ Model: <i>In Vitro</i>, <i>In Vivo</i> and Mechanistic Studies
Dose Dependent Effects of <i>Breynia cernua</i> Against the Paraquat Induced Parkinsonism like Symptoms in Animals’ Model: <i>In Vitro</i>, <i>In Vivo</i> and Mechanistic Studies Open
The aims and objectives of the study were to evaluate the antiParkinson’s (PD) potential of B cernua (BCE). B cernua (Poir.) Müll. Arg. (B cernua) is a member of the Phyllanthaceae family. HPLC revealed the presence of various phytochemica…
View article: Pharmacological evaluation of the hypoglycemic and anti- Alzheimer’s activities of aerial parts of Breynia distachia (Phyllanthaceae)
Pharmacological evaluation of the hypoglycemic and anti- Alzheimer’s activities of aerial parts of Breynia distachia (Phyllanthaceae) Open
Purpose: To determine the cytotoxic, bronchorelaxant, spasmolytic, antidiabetic, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, α-chymotrypsin and lipoxygenase inhibitory attributes of methanol and dichloromethane extracts of …
View article: Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections
Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections Open
The occurrence of fungal infections has increased over the past two decades. It is observed that superficial fungal infections are treated by conventional dosage forms, which are incapable of treating deep infections due to the barrier act…
View article: A Novel Distachionate from Breynia distachia Treats Inflammations by Modulating COX-2 and Inflammatory Cytokines in Rat Liver Tissue
A Novel Distachionate from Breynia distachia Treats Inflammations by Modulating COX-2 and Inflammatory Cytokines in Rat Liver Tissue Open
Breynia distachia is a plant of genus Breynia belonging to family Phyllanthaceae. This study was conducted to isolate and examine the anti-inflammatory attributes of the roots of Breynia distachia. Methanol extract from roots were prepared…
View article: A Comprehensive Review on Traditional Uses, Chemical Constituents, and Diverse Pharmacological Importance of the Genus Breynia
A Comprehensive Review on Traditional Uses, Chemical Constituents, and Diverse Pharmacological Importance of the Genus Breynia Open
The genus Breynia (family Phyllanthaceae) is widely distributed in Australia, Vietnam, Malaysia, and some regions of India.Traditionally, species of this genus were used to treat various disorders, like skin diseases, pain, cough, tonsilli…
View article: Verapamil attenuates oxidative stress and inflammatory responses in cigarette smoke (CS)-induced murine models of acute lung injury and CSE-stimulated RAW 264.7 macrophages via inhibiting the NF-κB pathway
Verapamil attenuates oxidative stress and inflammatory responses in cigarette smoke (CS)-induced murine models of acute lung injury and CSE-stimulated RAW 264.7 macrophages via inhibiting the NF-κB pathway Open
View article: RETRACTED: Revamping of Chronic Respiratory Diseases in Low- and Middle-Income Countries
RETRACTED: Revamping of Chronic Respiratory Diseases in Low- and Middle-Income Countries Open
Low- and middle-income countries (LMICs) endure an asymmetrically high burden of worldwide disease and death caused by chronic respiratory diseases (CRDs), i.e., asthma, emphysema, bronchiectasis, and post-tuberculosis lung disease (PTLD).…
View article: Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders
Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders Open
Plumeria rubra (L.) is a traditional folkloric medicinal herb used to treat cardiovascular disorders. The present investigation was methodically planned to investigate the pharmacological foundations for the therapeutic effectiveness of P.…