Malte Casper
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View article: Optical coherence tomography needle probe for real-time visualization of temperature-induced phase changes within subcutaneous fatty tissue
Optical coherence tomography needle probe for real-time visualization of temperature-induced phase changes within subcutaneous fatty tissue Open
Significance: Selective cryolipolysis is a widely used aesthetic procedure that cools subcutaneous adipose tissue to temperatures as low as to induce fat cell destruction. However, real-time monitoring techniques are lacking, l…
View article: Combined ion beam irradiation platform and 3D fluorescence microscope for cellular cancer research
Combined ion beam irradiation platform and 3D fluorescence microscope for cellular cancer research Open
To improve particle radiotherapy, we need a better understanding of the biology of radiation effects, particularly in heavy ion radiation therapy, where global responses are observed despite energy deposition in only a subset of cells. Her…
View article: Focused ion beam irradiation platform with a 3-D fluorescence imaging system: a flexible tool for cancer research
Focused ion beam irradiation platform with a 3-D fluorescence imaging system: a flexible tool for cancer research Open
To improve particle radiotherapy, we need a better understanding of the biology of targeted and non-targeted radiation effects. This is particularly important in the field of heavy ion radiation therapy where global effects are observed, y…
View article: High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue
High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue Open
View article: Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography
Assessing the impact of aging and blood pressure on dermal microvasculature by reactive hyperemia optical coherence tomography angiography Open
View article: Dynamic contrast in scanning microscopic OCT
Dynamic contrast in scanning microscopic OCT Open
While optical coherence tomography (OCT) provides a resolution down to 1 µm, it has difficulties in visualizing cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast enhancement…
View article: Dynamic contrast in scanning microscopic OCT
Dynamic contrast in scanning microscopic OCT Open
While optical coherence tomography (OCT) provides a resolution down to 1\nmicrometer it has difficulties to visualize cellular structures due to a lack\nof scattering contrast. By evaluating signal fluctuations, a significant\ncontrast enh…
View article: First Assessment of a Carbon Monoxide Laser and a Thulium Fiber Laser for Fractional Ablation of Skin
First Assessment of a Carbon Monoxide Laser and a Thulium Fiber Laser for Fractional Ablation of Skin Open
Background and Objectives A recent generation of 5,500 nm wavelength carbon monoxide (CO) lasers could serve as a novel tool for applications in medicine and surgery. At this wavelength, the optical penetration depth is about three times h…
View article: Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography
Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography Open
Background/Objectives Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the s…
View article: Real-time volumetric microscopy of in vivo dynamics and large-scale samples with SCAPE 2.0
Real-time volumetric microscopy of in vivo dynamics and large-scale samples with SCAPE 2.0 Open
View article: Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks Open
Optical coherence tomography (OCT) enables the non-invasive acquisition of high-resolution three-dimensional cross-sectional images at micrometer scale and is mainly used in the field of ophthalmology for diagnosis as well as monitoring of…
View article: Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography
Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography Open
Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture…
View article: Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM
Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM Open
Fluorescence lifetime imaging microscopy (FLIM) of intrinsic fluorophores such as nicotinamide adenine dinucleotide (NADH) allows for label-free quantification of metabolic activity of individual cells over time and in response to various …