Malte Johannes Hannich
YOU?
Author Swipe
View article: Oligoclonal bands and kappa free light chains: Competing parameters or complementary biomarkers?
Oligoclonal bands and kappa free light chains: Competing parameters or complementary biomarkers? Open
Both oligoclonal bands and KFLC have unique strengths and limitations that complement each other, potentially serving as complementary markers for evaluating intrathecal Ig synthesis in MS diagnosis. Further evidence is needed to establish…
View article: Prospective multicenter validation of a new laboratory workflow integrating the free light chains kappa quotient in CSF analysis-Protocol of the ORCAS study
Prospective multicenter validation of a new laboratory workflow integrating the free light chains kappa quotient in CSF analysis-Protocol of the ORCAS study Open
Introduction Free light chain kappa (FLCκ) are a newer sensitive biomarker to detect intrathecal immunoglobulin synthesis. Here we report the study protocol of the ORCAS study which will evaluate a novel laboratory work flow recently propo…
View article: A New Laboratory Workflow Integrating the Free Light Chains Kappa Quotient into Routine CSF Analysis
A New Laboratory Workflow Integrating the Free Light Chains Kappa Quotient into Routine CSF Analysis Open
We performed this cohort study to test whether further analysis of intrathecal inflammation can be omitted if the free light chain kappa (FLCκ) quotient is within the reference range in the corresponding quotient diagram. FLCκ concentratio…
View article: Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis
Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis Open
Background: The intrathecal humoral response is the characteristic diagnostic finding in the cerebrospinal fluid (CSF) analysis of patients with multiple sclerosis (MS). Although the average age of MS patients increases, little is known ab…
View article: Kappa Free Light Chains in Cerebrospinal Fluid in Inflammatory and Non-Inflammatory Neurological Diseases
Kappa Free Light Chains in Cerebrospinal Fluid in Inflammatory and Non-Inflammatory Neurological Diseases Open
Background: Oligoclonal bands represent intrathecal immunoglobulin G (IgG) synthesis and play an important role in the diagnosis of multiple sclerosis (MS). Kappa free light chains (KFLC) are increasingly recognized as an additional biomar…
View article: Decreased Intrathecal Concentrations of Free Light Chains Kappa in Multiple Sclerosis Patients Taking Very High Effective Disease-Modifying Treatment
Decreased Intrathecal Concentrations of Free Light Chains Kappa in Multiple Sclerosis Patients Taking Very High Effective Disease-Modifying Treatment Open
Free light chains kappa (FLCκ) in cerebrospinal fluid (CSF) are a part of the intrathecal immune response. This observational study was conducted to investigate the effects of different disease-modifying therapies (DMT) on the humoral intr…
View article: Time dependency of CSF cell count, lactate and blood-CSF barrier dysfunction after epileptic seizures and status epilepticus
Time dependency of CSF cell count, lactate and blood-CSF barrier dysfunction after epileptic seizures and status epilepticus Open
View article: Kappa Free Light Chains in the Context of Blood Contamination, and Other IgA- and IgM-Related Cerebrospinal Fluid Disease Pattern
Kappa Free Light Chains in the Context of Blood Contamination, and Other IgA- and IgM-Related Cerebrospinal Fluid Disease Pattern Open
In this retrospective, monocentric cohort study, we tested if an intrathecal free light chain kappa (FLC-k) synthesis reflects not only an IgG but also IgA and IgM synthesis. We also analysed if FLC-k can help to distinguish between an inf…
View article: Blood Product Supply for a Helicopter Emergency Medical Service
Blood Product Supply for a Helicopter Emergency Medical Service Open
Background: Long patient transport times to trauma centers are a well-known problem in sparsely populated regions with a low hospital density. Transfusion of red blood cell concentrates (RBC) and plasma improves outcome of tr…
View article: The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid
The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid Open
Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC …
View article: Free light chains kappa can differentiate between myelitis and noninflammatory myelopathy
Free light chains kappa can differentiate between myelitis and noninflammatory myelopathy Open
Ninety-six percent of patients with MS myelitis had an intrathecal synthesis of FLC-k in comparison with 55.6% for NMOSD and 14.3% of patients with noninflammatory myelopathy. The locally synthesized absolute amount of FLC-k was significan…
View article: Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population
Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population Open
Objective . Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations o…