Max Masthoff
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View article: Impact of migalastat on cerebral outcomes in fabry disease – results from the prospective observational FAMOUS trial
Impact of migalastat on cerebral outcomes in fabry disease – results from the prospective observational FAMOUS trial Open
Background Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the α-galactosidase A ( GLA ) gene, leading to an increased risk for white matter lesion (WML), stroke and cerebral microbleeds. Utilizing MRI d…
Pathological response after degradable starch microspheres transarterial chemoembolization for hepatocellular carcinoma: a Histopathological study on explanted livers Open
The present study provides important clinical evidence supporting the efficacy of DSM-TACE in inducing tumor necrosis, despite its short embolization time.
View article: Prognostic value of body composition out of PSMA-PET/CT in prostate cancer patients undergoing PSMA-therapy
Prognostic value of body composition out of PSMA-PET/CT in prostate cancer patients undergoing PSMA-therapy Open
Background This retrospective study aims to develop a deep learning-based approach to whole-body CT segmentation out of standard PSMA-PET-CT to assess body composition in metastatic castration resistant prostate cancer (mCRPC) patients pri…
Boosting the velocity detection limit of <span>3D</span> single‐cell tracking time‐lapse <span>MRI</span> by <span>balanced SSFP</span> imaging Open
Purpose Time‐lapse MRI allows for the dynamic tracking of single iron‐labeled cells. However, the time required for spatial encoding creates a temporal blur and, therefore, a limited ability to resolve moving cells. To study fast moving ce…
View article: Perimesencephalic Subarachnoid Hemorrhage Is Not Always a Benign Condition: Hemorrhage Volume as a Predictor for Complications and Clinical Outcome
Perimesencephalic Subarachnoid Hemorrhage Is Not Always a Benign Condition: Hemorrhage Volume as a Predictor for Complications and Clinical Outcome Open
Objective: The benign nature of perimesencephalic subarachnoid hemorrhage (pmSAH) can be challenged by the occurrence of complications. Given the limited prognostic value of established clinical parameters for the development of complicati…
View article: Size‐Controlled Self‐Assembly for Bimodal In Vivo Imaging
Size‐Controlled Self‐Assembly for Bimodal In Vivo Imaging Open
Contrast agents (CAs) are essential in biomedical imaging to aid in the diagnosis and therapy monitoring of disease. However, they are typically restricted to one imaging modality and have fixed properties such as size, shape, toxicity pro…
View article: Size‐Controlled Self‐Assembly for Bimodal In Vivo Imaging
Size‐Controlled Self‐Assembly for Bimodal In Vivo Imaging Open
Contrast agents (CAs) are essential in biomedical imaging to aid in the diagnosis and therapy monitoring of disease. However, they are typically restricted to one imaging modality and have fixed properties such as size, shape, toxicity pro…
Integrating CT Radiomics and Clinical Features to Optimize TACE Technique Decision-Making in Hepatocellular Carcinoma Open
Background/Objectives: To develop a decision framework integrating computed tomography (CT) radiomics and clinical factors to guide the selection of transarterial chemoembolization (TACE) technique for optimizing treatment response in non-…
Radial compressed sensing imaging improves the velocity detection limit of single cell tracking time‐lapse <span>MRI</span> Open
Purpose Time‐lapse MRI enables tracking of single iron‐labeled cells. Yet, due to temporal blurring, only slowly moving cells can be resolved. To study faster cells for example during inflammatory processes, accelerated acquisition is need…
Imaging-Derived Biomarkers Integrated with Clinical and Laboratory Values Predict Recurrence of Hepatocellular Carcinoma After Liver Transplantation Open
Imaging parameters derived from baseline contrast-enhanced CT showing malignant behavior and aggressive growth patterns, along with serum AFP and history of bridging therapies, show potential as biomarkers for predicting HCC recurrence aft…
Evaluation of effectiveness and safety of the large-format pRESET 6-50 thrombectomy stent-retriever in the endovascular treatment of ischemic stroke: real-world experiences from two tertiary comprehensive stroke centers Open
Objective Mechanical thrombectomy (MT) has become the standard treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO). First-pass (FP) reperfusion of the occluded vessel and fewer passes with stent retrievers show impr…
Dynamic cell tracking using time‐lapse <span>MRI</span> with variable temporal resolution Cartesian sampling Open
Purpose Temporal resolution of time‐lapse MRI to track individual iron‐labeled cells is limited by the required data‐acquisition time to fill k‐space and to reach sufficient SNR. Although motion of slowly patrolling monocytes can be resolv…
Clinical impact of a celiac axis stenosis in patients undergoing hepatobiliary surgery Open
Background Celiac axis stenosis (CAS) often is an incidental finding in terms of diagnostic for hepatobiliary surgery since most cases remain asymptomatic. It remains unclear whether CAS is a risk factor for postoperative complications aft…
Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy Open
Background Response assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional morphological and volumetric analyses of tumor lesions. The tumor microenvironment is pa…
Detection of Early Endothelial Dysfunction by Optoacoustic Tomography Open
Variations in vascular wall shear stress are often presumed to result in the formation of atherosclerotic lesions at specific arterial regions, where continuous laminar flow is disturbed. The influences of altered blood flow dynamics and o…
View article: Radiomics of Tumor Heterogeneity in 18F-FDG-PET-CT for Predicting Response to Immune Checkpoint Inhibition in Therapy-Naïve Patients with Advanced Non-Small-Cell Lung Cancer
Radiomics of Tumor Heterogeneity in 18F-FDG-PET-CT for Predicting Response to Immune Checkpoint Inhibition in Therapy-Naïve Patients with Advanced Non-Small-Cell Lung Cancer Open
We aimed to evaluate the predictive and prognostic value of baseline 18F-FDG-PET-CT (PET-CT) radiomic features (RFs) for immune checkpoint-inhibitor (CKI)-based first-line therapy in advanced non-small-cell lung cancer (NSCLC) patients. In…
Profiling specific cell populations within the inflammatory tumor microenvironment by oscillating-gradient diffusion-weighted MRI Open
Background The inflammatory tumor microenvironment (TME) is formed by various immune cells, being closely associated with tumorigenesis. Especially, the interaction between tumor-infiltrating T-cells and macrophages has a crucial impact on…
Establishment of an interdisciplinary vascular anomalies program in Tanzania, East Africa Open
Purpose The aim of this project is the sustainable implementation of a vascular anomalies (VA) program in Tanzania. Materials and methods In 2021 the first interdisciplinary VA program was initiated at Muhimbili National Hospital (MNH), Da…
View article: Multicentered analysis of percutaneous sclerotherapies in venous malformations of the face
Multicentered analysis of percutaneous sclerotherapies in venous malformations of the face Open
Objectives To evaluate the safety and outcome of image-guided sclerotherapy for treating venous malformations (VMs) of the face. Materials and methods A multicenter cohort of 68 patients with VMs primarily affecting the face was retrospect…
Multiparametric MRI enables for differentiation of different degrees of malignancy in two murine models of breast cancer Open
Objective The objective of this study was to non-invasively differentiate the degree of malignancy in two murine breast cancer models based on identification of distinct tissue characteristics in a metastatic and non-metastatic tumor model…
Clinical Outcome and Quality of Life of Multimodal Treatment of Extracranial Arteriovenous Malformations: The APOLLON Study Protocol Open
Purpose Arteriovenous malformations (AVMs) as rare diseases are diagnostically and therapeutically challenging. Due to the limited evidence regarding treatment outcome, prospective data are needed on how different treatment regimens affect…
View article: Image-guided embolization of arteriovenous malformations of the hand using Ethylene-vinyl Alcohol Copolymer
Image-guided embolization of arteriovenous malformations of the hand using Ethylene-vinyl Alcohol Copolymer Open
PURPOSE This study aimed to evaluate the safety and outcome of image-guided embolization for treating arteriovenous malformations (AVMs) of the hand using ethylene-vinyl alcohol copolymer (EVOH). METHODS A retrospective, multicenter cohort…
Diffusion-Weighted Imaging Prior to Percutaneous Sclerotherapy of Venous Malformations—Proof of Concept Study for Prediction of Clinical Outcome Open
Prediction of response to percutaneous sclerotherapy in patients with venous malformations (VM) is currently not possible with baseline clinical or imaging characteristics. This prospective single-center study aimed to predict treatment ou…