Mami Hirakawa
YOU?
Author Swipe
View article: Correction: Severe immune-related adverse event colitis successfully treated with single-dose infliximab in an older adult with hepatocellular carcinoma receiving STRIDE therapy
Correction: Severe immune-related adverse event colitis successfully treated with single-dose infliximab in an older adult with hepatocellular carcinoma receiving STRIDE therapy Open
View article: Organ preservation and seven-year survival after chemoimmunotherapy in a patient with metastatic gastric cancer
Organ preservation and seven-year survival after chemoimmunotherapy in a patient with metastatic gastric cancer Open
View article: Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial
Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial Open
PURPOSE Opioid-induced constipation is the most frequent and non–self-limiting adverse effect of opioid analgesia, reducing adherence and interfering with pain relief. This clinical trial aimed to clarify the preventive effect of naldemedi…
View article: Rationale and design of a multicenter, double-blinded, randomized, placebo-controlled trial to investigate the effects of naldemedine on opioid-induced constipation for patients with cancer pain: A study protocol
Rationale and design of a multicenter, double-blinded, randomized, placebo-controlled trial to investigate the effects of naldemedine on opioid-induced constipation for patients with cancer pain: A study protocol Open
View article: Barriers to and facilitators of implementation of the integration of oncology and palliative care in daily practice: a systematic review
Barriers to and facilitators of implementation of the integration of oncology and palliative care in daily practice: a systematic review Open
Background: Palliative care (PC) is widely recognized as an essential part of oncology care, and multiple academic societies have developed strong recommendations regarding the implementation of the integration of oncology and PC (IOP) in …
View article: Involvement of Dysfunction of Noradrenergic Neuronal System in the Depression-Like Behaviors in MAGE-D1 KO Mice
Involvement of Dysfunction of Noradrenergic Neuronal System in the Depression-Like Behaviors in MAGE-D1 KO Mice Open
Major depressive disorder (MDD) is a common mental disorder characterized by reduced motivation, diminished interest and pleasure, and anhedonia. We have proposed melanoma-associated antigen D1 (MAGE-D1) knock out (KO) mouse is a MDD model…
View article: Current status of integrating oncology and palliative care in Japan: a nationwide survey
Current status of integrating oncology and palliative care in Japan: a nationwide survey Open
View article: Current status of integrating oncology and palliative care in Japan: A nationwide survey
Current status of integrating oncology and palliative care in Japan: A nationwide survey Open
Background: Palliative care (PC) is increasingly recognized as essential for oncology care, and several academic societies strongly recommend integrating oncology and palliative care (IOP) in daily practice. Similarly, the Japanese governm…
View article: Current status of integrating oncology and palliative care in Japan: A nationwide survey
Current status of integrating oncology and palliative care in Japan: A nationwide survey Open
Background: Palliative care (PC) is increasingly recognized as essential for oncology care, and several academic societies strongly recommend integrating oncology and palliative care (IOP) in daily practice. Similarly, the Japanese governm…
View article: The deficit of quinolinic acid phosphoribosyltransferase induces hypolocomotion and cognitive impairment through impairment of dopaminergic neuronal function
The deficit of quinolinic acid phosphoribosyltransferase induces hypolocomotion and cognitive impairment through impairment of dopaminergic neuronal function Open
Quinolinic acid (QA) is a neurotoxic and implicated in the neurological disorders. QA is metabolized by quinolinic acid phosphoribosyltransferase (QPRT). However, the physiological roles of QPRT in central nervous system are still unclear.…
View article: Antidepressant effects of XJ-Et-8 in mice chronically exposed to corticosterone
Antidepressant effects of XJ-Et-8 in mice chronically exposed to corticosterone Open
High cortisol level in serum is one of the clinical features in depression. Exogenous administration of corticosterone (CORT) in rodents has been used as animal model of depression. Red resin of Dracaena cochinchinensis S.C. Chen, known as…
View article: Chronic unpredictable mild stress-induced depressive behavioral changes are associated with dopaminergic hyperfunction in the nuclues accumbens and serotonergic hypofunction in the prefrontal cortex and hippocampus of mice
Chronic unpredictable mild stress-induced depressive behavioral changes are associated with dopaminergic hyperfunction in the nuclues accumbens and serotonergic hypofunction in the prefrontal cortex and hippocampus of mice Open
Augmenting evidences disclose that stressful events evoke molecular alteration in brain, considered as a pathology in major depressive disorder (MDD). Chronic unpredictable mild stress (CUMS) induced hyperactivity in novel environment, dec…
View article: Supplementary Material for: Clinical Implications of Decreased Computed Tomography Value after Ramucirumab in Advanced Gastric Cancer
Supplementary Material for: Clinical Implications of Decreased Computed Tomography Value after Ramucirumab in Advanced Gastric Cancer Open
Objectives: This study aimed to evaluate whether a decrease of computed tomography (CT) value for tumors serves as a predictive marker in patients with advanced gastric cancer (aGC) who have undergone chemotherapy with vascul…
View article: Antibiotics may enhance the efficacy of gemcitabine treatment for advanced pancreatic cancer
Antibiotics may enhance the efficacy of gemcitabine treatment for advanced pancreatic cancer Open
Background: It has been reported that bacteria can metabolize gemcitabine (gem) into its inactive and contribute to the drug resistance. It was also reported that the resistance was abrogated by cotreatment with antibiotics [Geller LT, et …
View article: Perspectives and attitudes towards the integration of oncology and palliative care in Japan: A nationwide survey
Perspectives and attitudes towards the integration of oncology and palliative care in Japan: A nationwide survey Open
Background: Integration of oncology and palliative care (IOP) is recommended by several agencies, including the European Society for Medical Oncology. Given the slow evolution of IOP in practice, several barriers to its implementation may …
View article: Dynamic change of immune-related gene expression status during chemoradiotherapy in locally advanced esophageal cancer
Dynamic change of immune-related gene expression status during chemoradiotherapy in locally advanced esophageal cancer Open
View article: Current status of the integration of oncology and palliative care in Japan: A nationwide survey
Current status of the integration of oncology and palliative care in Japan: A nationwide survey Open
Background: Based on recommendations from several agencies, including the European Society for Medical Oncology, palliative care (PC) services are increasingly recognised as an essential part of oncology care. However, the implementation o…
View article: Involvement of kynurenine pathway in behavioral impairments in the offspring induced by the prenatal poly I: C injection
Involvement of kynurenine pathway in behavioral impairments in the offspring induced by the prenatal poly I: C injection Open
Backgrounds: Epidemiological studies have suggested that viral infection during pregnancy increases the risk for schizophrenia in the adult offspring. Offspring from pregnant mice injected with synthetic dsRNA [poly I:C] exhibit schizophre…
View article: Involvement of kynurenine 3-monooxygenase in the vulnerability to the PCP-induced behavioral abnormalities
Involvement of kynurenine 3-monooxygenase in the vulnerability to the PCP-induced behavioral abnormalities Open
Backgrounds: The tryptophan-kynurenine pathway generates several neuroactive compounds such as kynurenic acid (KA). KA is endogenous antagonist for N-methyl-D-aspartate (NMDA) and 7 nicotinic receptors and might contribute to the pathophy…
View article: Exposure to valproic acid during pregnancy induces autism endophenotypes in the male offspring
Exposure to valproic acid during pregnancy induces autism endophenotypes in the male offspring Open
Background:Autism is the developmental disorders characterized by social disability and stereotypy. Although the pathogenesis of autism is still unknown, it is epidemiologically reported that administration of valproic acid (VPA) during pr…
View article: Combination in prenatal nicotine exposure with juvenile isolation rearing induces depressive behavior and change of tryptophan metabolism
Combination in prenatal nicotine exposure with juvenile isolation rearing induces depressive behavior and change of tryptophan metabolism Open
Background: L-Tryptophan(TRP) is metabolized via the serotonin pathway and kynurenine pathway(KP). Several studies have demonstrated that the abnormality of both pathways is related to the development of the pathogenesis of depression. Smo…
View article: Early morphological change for predicting outcome in metastatic colorectal cancer after regorafenib
Early morphological change for predicting outcome in metastatic colorectal cancer after regorafenib Open
EMC could be a useful predictive marker for regorafenib in mCRC.
View article: Profile of trifluridine/tipiracil hydrochloride in the treatment of metastatic colorectal cancer: efficacy, safety, and place in therapy
Profile of trifluridine/tipiracil hydrochloride in the treatment of metastatic colorectal cancer: efficacy, safety, and place in therapy Open
TAS-102, with its robust survival efficacy and feasible toxicity, is one of the standard salvage-line treatments for patients with metastatic colorectal cancer (mCRC). No definitive data are available to determine which drug should be admi…
View article: Infusion site adverse events in breast cancer patients receiving highly emetic chemotherapy with prophylactic anti-emetic treatment with aprepitant and fosaprepitant: A retrospective comparison
Infusion site adverse events in breast cancer patients receiving highly emetic chemotherapy with prophylactic anti-emetic treatment with aprepitant and fosaprepitant: A retrospective comparison Open
The incidences of infusion site adverse events in chemotherapy regimens, including anthracyclines with either fosaprepitant or aprepitant as the anti-emetic, were not highlighted in the randomized trial comparing aprepitant and fosaprepita…
View article: Predictability of antitumor efficacy of cetuximab plus irinotecan based on skin rash severity according to observation period in patients with metastatic colorectal cancer following failure of fluorouracil, irinotecan and oxaliplatin
Predictability of antitumor efficacy of cetuximab plus irinotecan based on skin rash severity according to observation period in patients with metastatic colorectal cancer following failure of fluorouracil, irinotecan and oxaliplatin Open
The efficacy of cetuximab correlates with the severity of skin toxicity, although its onset may vary. The AIM of this retrospective study was to investigate the optimal observation period for skin rash as a predictor of the efficacy of cet…