Mamoru Koketsu
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View article: Watermelon Flower Petal-derived Apigenin Exhibits Anti-inflammatory Effects by Suppressing M1 Macrophage Polarization in Lipopolysaccharide/Interferon-gamma-co-stimulated RAW264.7 Cells
Watermelon Flower Petal-derived Apigenin Exhibits Anti-inflammatory Effects by Suppressing M1 Macrophage Polarization in Lipopolysaccharide/Interferon-gamma-co-stimulated RAW264.7 Cells Open
Background Watermelon fruits contain various bioactive compounds. However, the bioactivity of watermelon flower petals, specifically in the context of the anti-inflammatory effects, remains unknown. Objectives In this study, we aimed to ev…
View article: Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach
Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach Open
Prostate cancer is a major cause of cancer-related mortality in men worldwide. The anti-proliferative activity of Gongronema latifolium leaf extracts on some cancer cells has been reported. Herein, we investigated the growth inhibitory eff…
View article: Modification Structure of Cinnamaldehyde with Primary Amines by Reflux and Sonication Methods in the Presence of Sulfuric Acid as a Catalyst
Modification Structure of Cinnamaldehyde with Primary Amines by Reflux and Sonication Methods in the Presence of Sulfuric Acid as a Catalyst Open
Cinnamon is one of the most valuable natural resources that sustains life and exists freely in nature. Cinnamaldehyde is the primary compound in cinnamon oil. It has a unique structure that contains a benzene ring, an aldehyde group, and a…
View article: Chemical constituents and antioxidant activity of Britton's wild petunia (Ruellia brittoniana) flower
Chemical constituents and antioxidant activity of Britton's wild petunia (Ruellia brittoniana) flower Open
Sianturi GLR, Trisnawati EW, Koketsu M, Suryanti V. 2023. Chemical constituents and antioxidant activity of Britton's wild petunia (Ruellia brittoniana) flower. Biodiversitas 24: 3665-3672. Britton's wild petunia orkencana ungu (Ruellia br…
View article: Anti-Termite Activity of Azadirachta excelsa Seed Kernel and Its Isolated Compound against Coptotermes curvignathus
Anti-Termite Activity of Azadirachta excelsa Seed Kernel and Its Isolated Compound against Coptotermes curvignathus Open
Azadirachta excelsa, is a plant belonging to the same genus as Indian neem (Azadirachta indica), and its use as a pesticide is reported by few studies. Despite being a different species, it is expected to have the same biopesticide potenti…
View article: Data from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Data from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice Open
The flavone 4′,5,7-trihydroxy-3′,5′-dimethoxyflavone (tricin) present in rice, oats, barley, and wheat exhibits antigrowth activity in several human cancer cell lines and anti-inflammatory potential. However, the chemopreventive activity h…
View article: Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice Open
Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
View article: Supplementary Table 2 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Supplementary Table 2 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice Open
Supplementary Table 2 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
View article: Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice Open
Supplementary Table 1 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
View article: Supplementary Table 2 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Supplementary Table 2 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice Open
Supplementary Table 2 from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
View article: Data from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice
Data from Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Male Crj: CD-1 Mice Open
The flavone 4′,5,7-trihydroxy-3′,5′-dimethoxyflavone (tricin) present in rice, oats, barley, and wheat exhibits antigrowth activity in several human cancer cell lines and anti-inflammatory potential. However, the chemopreventive activity h…
View article: A systematic review and meta-analysis extraction techniques to reach the optimum asiaticoside content from the edible plant of Centella asiatica
A systematic review and meta-analysis extraction techniques to reach the optimum asiaticoside content from the edible plant of Centella asiatica Open
Asiaticoside is a promising compound of Centella asiatica. This review aims to investigate the effect of solid-liquid extraction techniques on asiaticoside yield. This research followed PRISMA guidelines. Of 361 studies identified, thirtee…
View article: Phenolic Glycosides Citrulluside H and Citrulluside T Isolated From Young Watermelon (<i>Citrullus lanatus</i>) Fruit Have Beneficial Effects Against <i>Cutibacterium acnes</i>-Induced Skin Inflammation
Phenolic Glycosides Citrulluside H and Citrulluside T Isolated From Young Watermelon (<i>Citrullus lanatus</i>) Fruit Have Beneficial Effects Against <i>Cutibacterium acnes</i>-Induced Skin Inflammation Open
Acne vulgaris, typically caused by Cutibacterium acnes ( C. acnes) involves chronic inflammation of the sebaceous follicles and is the most common skin disease, afflicting 85% of adolescents. We previously isolated 2 novel phenolic glycosi…
View article: Indonesian Medicinal Plants with Anti-inflammatory Properties and Potency as Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine
Indonesian Medicinal Plants with Anti-inflammatory Properties and Potency as Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine Open
Indonesia is a tropical country with mega-biodiversity. Several medicinal plants locally have been recognized for their anti-inflammatory properties and are traditionally used to help treat respiratory diseases. Chronic obstructive pulmona…
View article: Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth
Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth Open
Alpha-amylase is widely exploited as a drug target for preventing postprandial hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant-derived pregnanes is not fully understood. Herein, we used in vitro ,…
View article: Hydrochloric Acid and/or Sodium Hydroxide-modified Zeolite Y for Catalytic Hydrotreating of α-Cellulose Bio-Oil
Hydrochloric Acid and/or Sodium Hydroxide-modified Zeolite Y for Catalytic Hydrotreating of α-Cellulose Bio-Oil Open
The zeolite Y had been successfully modified by HCl and/or NaOH treatment. The modification of zeolite Y was performed by leaching the protonated zeolite Y (HY) in HCl solution (0.1 and 0.5 M) at 70 °C for 3 h resulting in DY0.1 and DY0.5.…
View article: <i>Clerodendrum volubile</i>Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats
<i>Clerodendrum volubile</i>Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats Open
Doxorubicin is widely applied in hematological and solid tumor treatment but limited by its off-target cardiotoxicity. Thus, cardioprotective potential and mechanism(s) of CVE in DOX-induced cardiotoxicity were investigated using cardiac a…
View article: pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles
pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles Open
In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, su…
View article: The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays
The High Content of Ent-11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays Open
Background: Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11αOH-KA) is a multifunctional biochemical found in some ferns, Pteris semipinnata, and its congeneric species. Although a number of therapeutic applications of 11αOH-KA have been …
View article: A New Depsidone from <i>Teloschistes flavicans</i> and the Antileukemic Activity
A New Depsidone from <i>Teloschistes flavicans</i> and the Antileukemic Activity Open
Lichens produce a variety of secondary metabolites that could be potential sources of pharmaceutically useful chemicals. However, only a limited number of lichen metabolites have been investigated for their biological significance. The obj…
View article: Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing <i>Allium sativum</i> L., <i>Terminalia bellirica</i> (Gaertn.) Roxb., <i>Curcuma aeruginosa</i> Roxb., and <i>Amomum compactum</i> Sol. ex. Maton in Rats
Acute and Subchronic Oral Toxicity Study of Polyherbal Formulation Containing <i>Allium sativum</i> L., <i>Terminalia bellirica</i> (Gaertn.) Roxb., <i>Curcuma aeruginosa</i> Roxb., and <i>Amomum compactum</i> Sol. ex. Maton in Rats Open
The polyherbal formulation containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol ex. Maton has been used for hypertension treatment empirically. Our previous study showed its…
View article: (-)-O-Methylcubebin from Vitex trifolia Enhanced Adipogenesis in 3T3-L1 Cells via the Inhibition of ERK1/2 and p38MAPK Phosphorylation
(-)-O-Methylcubebin from Vitex trifolia Enhanced Adipogenesis in 3T3-L1 Cells via the Inhibition of ERK1/2 and p38MAPK Phosphorylation Open
In this study, for the purpose of elucidation for antidiabetic components, we isolated and identified compounds that could become lead compounds for the development of antidiabetic agents from the herbal medicine Vitex trifolia, which is u…
View article: <i>Polyalthia longifolia</i> Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from <i>In Vitro</i> and <i>In Vivo</i> Studies
<i>Polyalthia longifolia</i> Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from <i>In Vitro</i> and <i>In Vivo</i> Studies Open
Plant-based therapies are being explored to prevent or treat several cancer types. The antioxidant properties of Polyalthia longifolia plant are well established. In our previous work, we demonstrated the presence of cytotoxic compounds in…
View article: Isolation of flavonol rhamnosides from Pometia pinnata leaves and investigation of α-glucosidase inhibitory activity of flavonol derivatives
Isolation of flavonol rhamnosides from Pometia pinnata leaves and investigation of α-glucosidase inhibitory activity of flavonol derivatives Open
In vitro antimicrobial and α-glucosidase inhibitory potential of enantiopure cycloalkylglycine derivatives: Insights into their in silico pharmacokinetic, druglikeness, and medicinal chemistry propertiesAdel Kadri, Kaiss Aouadi
View article: Preparation of Monoacylglycerol Derivatives from Indonesian Edible Oil and Their Antimicrobial Assay against Staphylococcus aureus and Escherichia coli
Preparation of Monoacylglycerol Derivatives from Indonesian Edible Oil and Their Antimicrobial Assay against Staphylococcus aureus and Escherichia coli Open
In the present work, linoleic acid and oleic acid were isolated from Indonesian corn oil and palm oil and they were used to prepare monoacylglycerol derivatives as the antibacterial agent. Indonesian corn oil contains 57.74% linoleic acid,…