Qing Zhou
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View article: Cellular dynamics in cerebrospinal fluid unveils the key regulators of intracranial response to immune checkpoint inhibitors in NSCLC brain metastases
Cellular dynamics in cerebrospinal fluid unveils the key regulators of intracranial response to immune checkpoint inhibitors in NSCLC brain metastases Open
Background Brain metastases (BrM) in non-small cell lung cancer (NSCLC) present a significant challenge due to poor prognosis. While immune checkpoint inhibitors (ICIs) have been standard treatments for NSCLC, their efficacy in BrM is vari…
View article: C1orf116 inhibits acquired resistance to EGFR inhibitors in EGFR mutant lung adenocarcinoma by suppressing the ATM/ATR pathways
C1orf116 inhibits acquired resistance to EGFR inhibitors in EGFR mutant lung adenocarcinoma by suppressing the ATM/ATR pathways Open
Low expression of C1orf116 enhances the DNA damage response and promotes resistance to EGFR inhibitors in LUAD. This discovery suggests a potential therapeutic approach to combat acquired resistance through targeting the ATM/ATR signaling …
View article: Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study
Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study Open
Purpose Several studies have already proven a significant correlation between the microbiota and lung cancer. In this study, we explore the potential relative oral and gut microbiota which influence the risk of lung cancer. Methods We util…
View article: Magnetic Fe <sub>3</sub> O <sub>4</sub> Nanoparticles Modified Hydroxyapatite Whisker: A Novel Framework with Superior Osteogenic Efficacy
Magnetic Fe <sub>3</sub> O <sub>4</sub> Nanoparticles Modified Hydroxyapatite Whisker: A Novel Framework with Superior Osteogenic Efficacy Open
The valid repair of bone defects requires considering precise elements mirroring native tissue and the efficiency of treatment reality. Magnetic biomaterial‐mediated mechanotransduction emerges as a critical mechanism for enhancing osteoge…
View article: Multiple ctDNA- based biomarkers predict benefit from selective RET Inhibition in non-small cell lung cancer patients: exploratory analysis of a prospective study
Multiple ctDNA- based biomarkers predict benefit from selective RET Inhibition in non-small cell lung cancer patients: exploratory analysis of a prospective study Open
Selective RET inhibitors such as pralsetinib have become the standard of care for patients with RET fusion-positive non-small cell lung cancer (NSCLC). Serial analysis of circulating tumor DNA (ctDNA) has proven effective in monitoring dis…
View article: Development of a nurse-led mHealth intervention framework for patients with chronic diseases: A systematic review and Delphi study
Development of a nurse-led mHealth intervention framework for patients with chronic diseases: A systematic review and Delphi study Open
Objective mHealth is increasingly becoming popular and useful for managing chronic diseases. Nurse-led mHealth services offer a patient-centred perspective, but many existing solutions lack a robust empirical foundation. Therefore, this st…
View article: Electrocatalytic Hydrogen Evolution of Cobalt Triaryl Corrole Bearing Methylsulphonyl Group
Electrocatalytic Hydrogen Evolution of Cobalt Triaryl Corrole Bearing Methylsulphonyl Group Open
Environmentally sustainable hydrogen energy electrocatalysts play a pivotal role in advancing renewable energy systems. In this study, we present the synthesis of three new cobalt tri‐ aryl corrole complexes (1, 2, 3) with varying methylsu…
View article: Impact of multidisciplinary collaborative jejunal nutrition care on nutritional status and quality of life in severely burned patients
Impact of multidisciplinary collaborative jejunal nutrition care on nutritional status and quality of life in severely burned patients Open
To access the impact of multidisciplinary collaborative jejunal nutrition care on the nutritional status, pain level, wound healing, and quality of life in severely burned cases. A total of 120 cases with severe burns who visited our hospi…
View article: Supplementary Table S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S6. The circulating tumor DNA mutation results for 4 patients with lead time over 30 months.
View article: Supplementary Figure S4 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S4 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S4. Kaplan-Meier analysis of the survival time since last blood, comparing patients with longitudinal undetectable MRD to those with longitudinal detectable MRD (last blood draw positive), excluding synchronous recurre…
View article: Supplementary Figure S2 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S2 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S2. Kaplan-Meier Analysis of Disease-Free Survival (DFS) in the Overall Population.
View article: Data from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Data from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Purpose:The prognostic value of molecular residual disease (MRD) in non–small cell lung cancer (NSCLC) is well established, with treatment-guiding results anticipated. Here, we present updated analyses from our previously published cohort …
View article: Supplementary Figure S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S5. CT and MRI images of patients with brain-only metastases who had longitudinal undetectable MRD. The red arrows indicate the location of metastatic lesions.
View article: Supplementary Figure S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S6 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S6. Kaplan-Meier Analysis of Disease-Free Survival (DFS) for patients with intermittently detectable MRD versus persistently detectable MRD. Patients who spontaneously converted to undetectable MRD after the first posi…
View article: Supplementary Table S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S5 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S5. The circulating tumor DNA mutation results for 5 MRD+ patients without recurrence.
View article: Supplementary Figure S8 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S8 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S8. (A) Estimated hazard rate curves for event occurrences in stage II/III patients with landmark undetectable MRD, who received adjuvant therapy. (B) Estimated hazard rate curves for event occurrences in stage II/III …
View article: Supplementary Table S2 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S2 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S2. Cox regression for progression-free survival based on longitudinal MRD detection.
View article: Supplementary Figure S1 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S1 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S1. ctDNA-MRD detection framework
View article: Supplementary Table S3 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S3 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S3. Univariate and Multivariate Cox Regression Analysis.
View article: Supplementary Figure S3 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S3 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S3. (A) Kaplan–Meier analysis of disease-free survival (DFS) stratified by landmark MRD status for LUAD patients. (B) Kaplan–Meier analysis of DFS stratified by longitudinal MRD status for LUAD patients. (C) Kaplan-Mei…
View article: Supplementary Table S1 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S1 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S1. Performance Metrics of Landmark and Longitudinal MRD Analyses Stratified by Tumor Type.
View article: Supplementary Table S4 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S4 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S4. Clinical characteristics of 13 cases recurred with longitudinal undetected MRD.
View article: Supplementary Figure S7 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Figure S7 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Supplementary Figure S7. Univariate cox analysis of MRD lead time with ctDNA level and maxVAF, as continuous variables
View article: Supplementary Table S7 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer
Supplementary Table S7 from Follow-up Analysis Enhances Understanding of Molecular Residual Disease in Localized Non–Small Cell Lung Cancer Open
Table S7. Comparison of baseline characteristics for patients exploring the predictive value of undetectable and detectable MRD with or without adjuvant therapy.