Jinpu Yu
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View article: Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis
Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis Open
Malignant mesothelioma of the tunica vaginalis testis (MMTVT) is a rare malignancy originating from mesothelial cells of the testicular tunica vaginalis. Due to its insidious onset and local aggressiveness, most patients are diagnosed at a…
View article: Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma
Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma Open
Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma…
View article: A new perspective on targeting pulmonary arterial hypertension: Programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis)
A new perspective on targeting pulmonary arterial hypertension: Programmed cell death pathways (Autophagy, Pyroptosis, Ferroptosis) Open
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease characterized by elevated pulmonary vascular resistance, progressive increases in pulmonary artery pressures, ultimately leading to right-sided heart failure, and pot…
View article: Preliminary exploration of poor prognostic factor IL-33 and its involvement in perioperative immunotherapy in stage II–III lung squamous cell carcinoma: a retrospective cohort study
Preliminary exploration of poor prognostic factor IL-33 and its involvement in perioperative immunotherapy in stage II–III lung squamous cell carcinoma: a retrospective cohort study Open
High IL-33 expression in cancer tissues is associated with poor prognosis in stage II-III LUSC. IL-33 blockade combined with ICIs may provide new treatment regimens and ideas for perioperative immunotherapy in stage II-III LUSC patients.
View article: Optical Genome Mapping Reveals the Landscape of Structural Variations and Their Clinical Significance in HBOC-Related Breast Cancer
Optical Genome Mapping Reveals the Landscape of Structural Variations and Their Clinical Significance in HBOC-Related Breast Cancer Open
Background: Structural variations (SVs) are common genetic alterations in the human genome. However, the profile and clinical relevance of SVs in patients with hereditary breast and ovarian cancer (HBOC) syndrome (germline BRCA1/2 mutation…
View article: Expert Consensus on the Diagnosis and Treatment of NRG1/2 Gene Fusion Solid Tumors
Expert Consensus on the Diagnosis and Treatment of NRG1/2 Gene Fusion Solid Tumors Open
The fusion genes NRG1 and NRG2 , members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, NRG1 retains its EGF-like active domain, binds to the ERBB ligand family, and triggers intra…
View article: Optimal planning of distributed generation and energy storage systems in DC distribution networks with application of category-based multi-objective algorithm
Optimal planning of distributed generation and energy storage systems in DC distribution networks with application of category-based multi-objective algorithm Open
The strategic positioning and appropriate sizing of Distributed Generation (DG) and Battery Energy Storage Systems (BESS) within a DC delivery network are crucial factors that influence its economic feasibility and dependable performance. …
View article: Expert consensus on the diagnosis and treatment of <scp>RET</scp> gene fusion <scp>non‐small</scp> cell lung cancer in <scp>China</scp>
Expert consensus on the diagnosis and treatment of <span>RET</span> gene fusion <span>non‐small</span> cell lung cancer in <span>China</span> Open
The rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell‐surface molecules responsible for transmitting signals that regulate cell growth and differentiation. In non‐small cell lung cancer (NSCLC), RET…
View article: Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma
Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma Open
Malignant pleural mesothelioma (MPM) is a malignant tumor originating from the pleura, and its incidence has been increasing in recent years. Due to the insidious onset and strong local invasiveness of MPM, most patients are diagnosed in t…
View article: Real‐world treatment patterns and clinical outcomes among follicular lymphoma patients in the SEER‐Medicare population
Real‐world treatment patterns and clinical outcomes among follicular lymphoma patients in the SEER‐Medicare population Open
Introduction: Follicular lymphoma (FL) is the second most common lymphoma with annual estimated new cases of approximately 14,000 in the US. Survival outcomes in FL patients vary depending on various risk factors. Patients generally respon…
View article: Intratumoral microbial heterogeneity affected tumor immune microenvironment and determined clinical outcome of HBV-related HCC
Intratumoral microbial heterogeneity affected tumor immune microenvironment and determined clinical outcome of HBV-related HCC Open
Background and Aims: The intratumoral microbiome has been reported to regulate the development and progression of cancers. We aimed to characterize intratumoral microbial heterogeneity (IMH) and establish microbiome-based molecular subtypi…
View article: Supplementary File from Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family
Supplementary File from Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family Open
PDF file 1705K, Supplementary methods, tables, and figures Supplemental Table 1. Characteristics of the 385 GC cases included in the study Supplemental Table 2. Identification of key microRNAs associated with GC survival Supplemental Table…
View article: Figure S3 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Figure S3 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
The association of (A) LINE-1 RTs / (B) immunocyte counts with smoking levels.
View article: Figure S4 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Figure S4 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
A model depicts homologous recombination between the exogenous L1-FGGY and the endogenous FGGY. (A) Detection of the value of different fragments in genome DNA (gDNA). (B) Detection of the value of different fragments in complementary DNA …
View article: Supplementary File from Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family
Supplementary File from Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family Open
PDF file 1705K, Supplementary methods, tables, and figures Supplemental Table 1. Characteristics of the 385 GC cases included in the study Supplemental Table 2. Identification of key microRNAs associated with GC survival Supplemental Table…
View article: Figure S6 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Figure S6 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
The schematic diagram for the hypothesis of smoking-induced genome disturbance and tumor development and progression. The red oval indicates upregulation, and the green oval indicates downregulation.
View article: Figure S1 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Figure S1 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
LINE-1 RTs were validated in cell lines.
View article: Figure S4 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Figure S4 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
A model depicts homologous recombination between the exogenous L1-FGGY and the endogenous FGGY. (A) Detection of the value of different fragments in genome DNA (gDNA). (B) Detection of the value of different fragments in complementary DNA …
View article: Figure S6 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Figure S6 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
The schematic diagram for the hypothesis of smoking-induced genome disturbance and tumor development and progression. The red oval indicates upregulation, and the green oval indicates downregulation.
View article: Data from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Data from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
Somatic long interspersed element-1 (LINE-1) retrotransposition is a genomic process that relates to gene disruption and tumor occurrence. However, the expression and function of LINE-1 retrotransposition in lung squamous cell carcinoma (L…
View article: Data from Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family
Data from Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family Open
Purpose: Our aim was to investigate whether microRNAs can predict the clinical outcome of patients with gastric cancer. We used integrated analysis of microRNA and mRNA expression profiles to identify gastric cancer microRNA subtypes and t…
View article: Figure S1 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY
Figure S1 from LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor-Suppressor Gene FGGY Open
LINE-1 RTs were validated in cell lines.