Adrian Wong
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View article: Speaking in Tones: The role of lexical tones in Chinese-speaking Primary Progressive Aphasia
Speaking in Tones: The role of lexical tones in Chinese-speaking Primary Progressive Aphasia Open
Two-thirds of the world’s languages, including Mandarin and Cantonese, employ pitch variation to convey meaning (lexical tone). Existing diagnostic frameworks for primary progressive aphasia (PPA) have been developed for English speakers, …
View article: Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer
Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer Open
Treatments for high-grade serous ovarian cancer (HGSOC) are initially effective but most invariably fail. Although they can successfully suppress the bulk of the tumour cell population, residual cancer cells can enter alternative therapy-r…
View article: Automated detection of sea cucumbers in turbid subtidal marine habitats: An explainable approach
Automated detection of sea cucumbers in turbid subtidal marine habitats: An explainable approach Open
Deposit-feeding sea cucumbers perform important ecosystem functions, enhancing nutrient cycling and maintaining ecosystem health. Understanding this function over large spatial scales requires substantial population surveys, which can be l…
View article: Zinc Deficiency in the Pediatric Population and Its Impact on Respiratory Health: A Review
Zinc Deficiency in the Pediatric Population and Its Impact on Respiratory Health: A Review Open
Zinc is an essential element for growth and immunity. Data from China suggested 27.0% of zinc deficiency in Chinese children. This review highlights the evidence of zinc deficiency on respiratory health, including COVID-19, pneumonia, and …
View article: Lipid dysregulation and delirium in older adults: A review of the current evidence and future directions
Lipid dysregulation and delirium in older adults: A review of the current evidence and future directions Open
Delirium is a complex medical condition marked by acute episodes of cognitive dysfunction and behavioral disturbances, with a multifaceted etiology and challenging management across various clinical settings. Older adults, particularly in …
View article: An Algorithm Designed for Rapid Automated Cardiac Data Processing: Integrating Autocorrelation, a Genetic Algorithm and a Tracking Index
An Algorithm Designed for Rapid Automated Cardiac Data Processing: Integrating Autocorrelation, a Genetic Algorithm and a Tracking Index Open
View article: Automated Detection of Sea Cucumbers in Turbid Subtidal Marine Habitats: An Explainable Approach
Automated Detection of Sea Cucumbers in Turbid Subtidal Marine Habitats: An Explainable Approach Open
View article: Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds Open
Importance Cerebral small vessel disease (SVD) is associated with various cerebrovascular outcomes, but data on sex differences in SVD are scarce. Objective To investigate whether the frequency, severity, and distribution of cerebral micro…
View article: More than a piece of cake: Noun classifier processing in primary progressive aphasia
More than a piece of cake: Noun classifier processing in primary progressive aphasia Open
INTRODUCTION Clinical understanding of primary progressive aphasia (PPA) has been primarily derived from Indo‐European languages. Generalizing certain linguistic findings across languages is unfitting due to contrasting linguistic structur…
View article: PULSATILITY INDEX OUTPERFORMS CONVENTIONAL IMAGING MARKERS IN THE ASSOCIATION WITH COGNITION IN COMMUNITY ELDERLY
PULSATILITY INDEX OUTPERFORMS CONVENTIONAL IMAGING MARKERS IN THE ASSOCIATION WITH COGNITION IN COMMUNITY ELDERLY Open
View article: P-256 Albumin-bilirubin (ALBI) grade at 6 weeks post-diagnosis is a better prognosticator than baseline ALBI in intrahepatic cholangiocarcinoma
P-256 Albumin-bilirubin (ALBI) grade at 6 weeks post-diagnosis is a better prognosticator than baseline ALBI in intrahepatic cholangiocarcinoma Open
View article: Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation
Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation Open
Objectives Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate the risks of intracranial hemorrhage and i…
View article: A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study
A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study Open
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View article: Learning to Fold Real Garments with One Arm: A Case Study in Cloud-Based Robotics Research
Learning to Fold Real Garments with One Arm: A Case Study in Cloud-Based Robotics Research Open
Autonomous fabric manipulation is a longstanding challenge in robotics, but evaluating progress is difficult due to the cost and diversity of robot hardware. Using Reach, a cloud robotics platform that enables low-latency remote execution …
View article: Socratic Models: Composing Zero-Shot Multimodal Reasoning with Language
Socratic Models: Composing Zero-Shot Multimodal Reasoning with Language Open
Large pretrained (e.g., "foundation") models exhibit distinct capabilities depending on the domain of data they are trained on. While these domains are generic, they may only barely overlap. For example, visual-language models (VLMs) are t…
View article: Robust forecasting using predictive generalized synchronization in reservoir computing
Robust forecasting using predictive generalized synchronization in reservoir computing Open
Reservoir computers (RCs) are a class of recurrent neural networks (RNNs) that can be used for forecasting the future of observed time series data. As with all RNNs, selecting the hyperparameters in the network to yield excellent forecasti…
View article: Comparison of time spent and score in digital recognition test and free recall tests in the identification of mild cognitive impairment and Alzheimer disease
Comparison of time spent and score in digital recognition test and free recall tests in the identification of mild cognitive impairment and Alzheimer disease Open
Background Digital memory tests are proposed for the screening of mild cognitive impairment (MCI) and Alzheimer disease (AD). However, previous studies are seldom measuring the time spent of a participant in a memory test. So, it is unclea…
View article: Evaluation of Digital Drawing Tests and Paper-and-Pencil Drawing Tests for the Screening of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies
Evaluation of Digital Drawing Tests and Paper-and-Pencil Drawing Tests for the Screening of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies Open
Digital drawing tests have been proposed for cognitive screening over the past decade. However, the diagnostic performance is still to clarify. The objective of this study was to evaluate the diagnostic performance among different types of…
View article: Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images
Machine-learning method for localization of cerebral white matter hyperintensities in healthy adults based on retinal images Open
Retinal vessels are known to be associated with various cardiovascular and cerebrovascular disease outcomes. Recent research has shown significant correlations between retinal characteristics and the presence of cerebral small vessel disea…
View article: MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease
MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease Open
Alzheimer's Disease-resemblance atrophy index (AD-RAI) is an MRI-based machine learning derived biomarker that was developed to reflect the characteristic brain atrophy associated with AD. Recent study showed that AD-RAI (≥0.5) had the bes…
View article: Phenotyping of Asthma Exacerbations Using Day-to-Day Variability in Oscillometry Measures in Children
Phenotyping of Asthma Exacerbations Using Day-to-Day Variability in Oscillometry Measures in Children Open
View article: Erratum
Erratum Open
In the paper by Mok et al. (“Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.”Alzheimer's Dement. 2020; 16: 1571-1581. https://doi.org/10.1002/alz.12143), an error oc…
View article: Forecasting Using Reservoir Computing: The Role of Generalized\n Synchronization
Forecasting Using Reservoir Computing: The Role of Generalized\n Synchronization Open
Reservoir computers (RC) are a form of recurrent neural network (RNN) used\nfor forecasting time series data. As with all RNNs, selecting the\nhyperparameters presents a challenge when training on new inputs. We present a\nmethod based on …
View article: Correction: Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study
Correction: Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study Open
View article: Pandemic of the aging society — sporadic cerebral small vessel disease
Pandemic of the aging society — sporadic cerebral small vessel disease Open
Age-related sporadic cerebral small vessel disease (CSVD) has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population. The widespread application of and advances in brain m…
View article: Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial
Aerobic exercise in older people with subclinical sporadic cerebral small vessel disease: A randomized clinical trial Open
Introduction The benefit and risk of aerobic exercise among older people harboring advanced cerebral small vessel disease (CSVD) upon cognition, mood, and motor functions are unknown. Methods This rater‐blind randomized trial examined effe…
View article: Correction: Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study (Preprint)
Correction: Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study (Preprint) Open
UNSTRUCTURED The Acknowledgments revised to: We thank Professor JE Morley, Saint Louis University School of Medicine, USA, who invented the Rapid cognitive screen, for having agreed to let us adapt it into an online version suited for old…
View article: Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study
Electronic Cognitive Screen Technology for Screening Older Adults With Dementia and Mild Cognitive Impairment in a Community Setting: Development and Validation Study Open
Background A digital cognitive test can be a useful and quick tool for the screening of cognitive impairment. Previous studies have shown that the diagnostic performance of digital cognitive tests is comparable with that of conventional pa…
View article: Mapping the contributing factors of depression in community elders
Mapping the contributing factors of depression in community elders Open
Background The contributing factors of depressive symptoms in elderlies are not known quite well. This study aims to investigate the clinical and neuroimaging risk factors of depression in community elderlies. Method Clinical risk factors …
View article: Idiosyncratic neurolinguistic presentations of Chinese speaking primary progressive aphasia individuals
Idiosyncratic neurolinguistic presentations of Chinese speaking primary progressive aphasia individuals Open
Background Past research on Primary Progressive Aphasia(PPA) has been centered around English language, thus there is limited knowledge to the presentations of linguistic features that differ from the English language. Chinese language pos…