Explanipedia

Mechanisms of the Effects of Polyphenols on Diabetic Nephropathy Open

Masumi Kamiyama, Kazumoto Iijima, Rema Okuzawa, Ryou KAWATA, Akiharu Kimura , et al. · 2025

Diabetic nephropathy is a major challenge in medicine. While a variety of mechanisms underlie the onset and progression of diabetic nephropathy, oxidative stress is critical because it promotes inflammation and creates a vicious cycle that…

Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis Open

Ryo Miyake, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama , et al. · 2025

Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis Open

Ryo Miyake, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama , et al. · 2025

Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, the spinal cord, and the brain. Neuropathic pain leads to changes in synaptic plasticity in the anterior cingulate cortex (ACC). However, whether such c…

Role of Intraoperative Nerve Monitoring in Preventing Peripheral Nerve Injury During Total Hip Arthroplasty in High-Risk Patients Open

Teiji Harada, Hiroshi Iwasaki, Takaya Taniguchi, Wataru Taniguchi, Daisuke Nishiyama , et al. · 2025

Background Intraoperative nerve monitoring (IONM) plays a crucial role in preventing peripheral nerve injury during total hip arthroplasty (THA). However, its efficacy in THA remains controversial. This study aimed to evaluate the efficacy…

Analgesic effects of intraarterial injection of imipenem/cilastatin sodium in a rat model of knee osteoarthritis Open

Yuki Matsuyama, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Hidenobu Tamai , et al. · 2025

Angiogenesis plays a role in the mechanism underlying musculoskeletal pain; thus, embolization of blood vessels may exert an analgesic effect. Recent clinical studies have reported promising therapeutic outcomes for arterial embolization i…

Augmented Intrarenal and Urinary Angiotensinogen in Diabetic Nephropathy: The Role of Isoflavones Open

Masumi Kamiyama, Kazumoto Iijima, Rema Okuzawa, Ryou KAWATA, Akiharu Kimura , et al. · 2025

The circulating renin–angiotensin system (RAS) is an endocrine system with key functions in maintaining blood pressure, fluid volume, and electrolytes. The RAS in the kidney (intrarenal RAS) plays a critical role in the onset and progressi…

Tropical coastlines robustizing stratospheric quasi-biennial cycle Open

Manabu D. Yamanaka, Shin‐Ya Ogino · 2024

Robust existence of the equatorial-stratospheric quasi-biennial oscillation (QBO)^1,² affecting the global climate^3,4,5,6 has been explained by heating-independent wave-mean flow interaction^7,8,9,…

Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn Open

Takeru Ueno, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama , et al. · 2024

Methylglyoxal (MGO), a highly reactive dicarbonyl metabolite of glucose primarily formed during the glycolytic pathway, is a precursor of advanced glycation end-products (AGEs). Recently, numerous studies have shown that MGO accumulation c…

Analgesic Effects of Intraarterial Injection of Imipenem Cilastatin Sodium in a Rat Model of Knee Osteoarthritis Open

Yuki Matsuyama, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Hidenobu Tamai , et al. · 2024

Development of a Novel Rat Knee Osteoarthritis Model Induced by Medial Meniscus Extrusion Open

Daisuke Fukui, Daisuke Nishiyama, Manabu D. Yamanaka, Hidenobu Tamai, Naoko Nishio , et al. · 2023

Objective The medial meniscus extrusion (MME) is associated with increased stress on the knee joint, which leads to cartilage degeneration. To evaluate the etiology of knee osteoarthritis, it is extremely important to create animal models …

Validation of a smartphone-based gait analysis focusing on waveform similarity Open

Satoshi Arita, Daisuke Nishiyama, Daisuke Fukui, Manabu D. Yamanaka, Hiroshi Yamada · 2023

Objective: Gait analysis using Inertial measurement units (IMUs) have gained attention owing to low economic and logistical constraints and obtaining spatiotemporal gait parameters with the same accuracy as that of conventional gait analys…

Transient receptor potential ankyrin 1 in the knee is involved in osteoarthritis pain Open

Hidenobu Tamai, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Daisuke Fukui , et al. · 2023

Transient receptor potential families play important roles in the pathology of osteoarthritis (OA) of the knee. While transient receptor potential ankyrin 1 (TRPA1) is also an essential component of the pathogenesis of various arthritic co…

Erratum for Lumbar Fusion including Sacroiliac Joint Fixation Increases the Stress and Angular Motion at the Hip Joint: A Finite Element Study Open

Takuhei Kozaki, Hiroshi Hashizume, Hiroyuki Oka, Satoru Ohashi, Yoh Kumano , et al. · 2023

[This corrects the article DOI: 10.22603/ssrr.2021-0231.].

Peatland groundwater level in the Indonesian maritime continent as an alert for El Niño and moderate positive Indian Ocean dipole events Open

Albertus Sulaiman, Mitsuru Osaki, Hidenori Takahashi, Manabu D. Yamanaka, Raden Dwi Susanto , et al. · 2023

In general, it is known that extreme climatic conditions such as El Niño and positive Indian Ocean Dipole (IOD+) cause prolonged drought in Indonesia's tropical peatlands so that groundwater levels (GWL) drop and peat is prone to fire. How…

Spinopelvic fusion surgery from lower thoracic spine to pelvis increased hip joint moment–motion analysis Open

Takuhei Kozaki, Hiroshi Hashizume, Hiroyuki Oka, Junji Katsuhira, Koichi Kawabata , et al. · 2022

Lack of transient receptor potential ankyrin 1 (TRPA1) retards cutaneous wound healing in mice: A preliminary study Open

Shizumasa Murata, Manabu D. Yamanaka, Wataru Taniguchi, Daiki Kajioka, Kentaro Suzuki , et al. · 2022

Lumbar Fusion including Sacroiliac Joint Fixation Increases the Stress and Angular Motion at the Hip Joint: A Finite Element Study Open

Takuhei Kozaki, Hiroshi Hashizume, Hiroyuki Oka, Satoru Ohashi, Yoh Kumano , et al. · 2022

The average and maximum contact stress of the hip joint was the highest in the S2F model. Thus, lumbosacral fusion surgery with sacroiliac joint fixation placed added stress on the hip joint. We propose that this was a consequence of adjac…

Medial meniscus extrusion and varus tilt of joint line convergence angle increase stress in the medial compartment of the knee joint in the knee extension position ‐finite element analysis‐ Open

Takuhei Kozaki, Daisuke Fukui, Ei YAMAMOTO, Daisuke Nishiyama, Manabu D. Yamanaka , et al. · 2022

Purpose Although it has been recognized that the medial meniscus extrusion (MME) leads to progressive cartilage loss and osteoarthritis (OA), about 20% of cases with MME had minor symptoms and poor progression of knee OA. However, it is st…

Feature selection to classify lameness using a smartphone-based inertial measurement unit Open

Satoshi Arita, Daisuke Nishiyama, Takaya Taniguchi, Daisuke Fukui, Manabu D. Yamanaka , et al. · 2021

Background and objectives Gait can be severely affected by pain, muscle weakness, and aging resulting in lameness. Despite the high incidence of lameness, there are no studies on the features that are useful for classifying lameness patter…

Deep generative models for automated muscle segmentation in computed tomography scanning Open

Daisuke Nishiyama, Hiroshi Iwasaki, Takaya Taniguchi, Daisuke Fukui, Manabu D. Yamanaka , et al. · 2021

Accurate gluteus medius (GMd) volume evaluation may aid in the analysis of muscular atrophy states and help gain an improved understanding of patient recovery via rehabilitation. However, the segmentation of muscle regions in GMd images fo…

Anti-allodynic and promotive effect on inhibitory synaptic transmission of riluzole in rat spinal dorsal horn Open

Ryo Taiji, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Shunji Tsutsui , et al. · 2021

Weather radar detection of planetary boundary layer and smoke layer top of peatland fire in Central Kalimantan, Indonesia Open

Muhammad Arif Rahman, Devis Styo Nugroho, Manabu D. Yamanaka, Masahiro Kawasaki, Osamu Kozan , et al. · 2021

During the dry period of August–October 2015, a C-band Doppler weather radar of the BMKG station in a fire-prone peatland area, Palangka Raya, detected echoes with reflectivity values between − 19 and + 34 dBZ at a height below 2–3 km and …

Analysis of the relationship between knee osteoarthritis weight–bearing pain and transient receptor potential vanilloid 1 using the CatWalk system Open

Wataru Taniguchi, Naoko Nishio, Manabu D. Yamanaka, Ryotaro Taiji, Shunji Tsutsui , et al. · 2019

Osteoarthritis of the knee (knee OA) is a common disease in the elderly, and the chief complaint of these patients is knee pain. Knee OA pain reduces the activities of daily living and the quality of life in these patients. The degree of p…

Interfacial, International and Interdisciplinary Studies on Maritime-Continent Peatland Controlling Global Climate Open

Manabu D. Yamanaka · 2019

インドネシア「海大陸」は真の大陸に比べ遥かに長い海岸線をもち，これに沿って日周期海陸風と共に生じる世界最強の雨雲が解放する潜熱は，日射（－日傘効果）と赤外放射（－温室効果）の差を埋めている．この地球保温機構は，同時に保水機構であり，それらと共に陸海空三重境界の不連続を回避する仕組の一つとして作られた生物圏や，その内部に派生した人類圏の生命維持機構でもある．特にスマトラ・カリマンタン両島の海岸の低湿地林とその遺骸蓄積が作る泥炭地は多量の炭素を固定しており，それらの輸出用農作物…

Analysis of Spatial and Seasonal Differences in the Diurnal Rainfall Cycle over Sumatera Revealed by 17-Year TRMM 3B42 Dataset Open

Abd. Rahman As-syakur, Keiji Imaoka, Kakuji OGAWARA, Manabu D. Yamanaka, Tasuku Tanaka , et al. · 2019

We analyzed 3-hourly Tropical Rainfall Measuring Mission multi-satellite analysis (TRMM 3B42) version-7 data for the 17-year period 1998-2014 to investigate seasonal and geographic characteristics of the diurnal rainfall cycle (DRC) over S…

Diurnal cycle over a coastal area of the Maritime Continent as derived by special networked soundings over Jakarta during HARIMAU2010 Open

Masaki Katsumata, Shuichi Mori, Jun-ichi Hamada, Miki Hattori, Fadli Syamsudin , et al. · 2018

Meridional march of diurnal rainfall over Jakarta, Indonesia, observed with a C-band Doppler radar: an overview of the HARIMAU2010 campaign Open

Shuichi Mori, Jun-ichi Hamada, Miki Hattori, Peiming Wu, Masaki Katsumata , et al. · 2018

Maritime continent coastlines controlling Earth’s climate Open

Manabu D. Yamanaka, Shin‐Ya Ogino, Peiming Wu, Jun-ichi Hamada, Shuichi Mori , et al. · 2018

During the Monsoon Asian Hydro−Atmosphere Scientific Research and Prediction Initiative (MAHASRI; 2006–16), we carried out two projects over the Indonesian maritime continent (IMC), constructing the Hydrometeorological Array for Intraseaso…

Tropical Coastal Dehydrator in Global Atmospheric Water Circulation Open

Shin‐Ya Ogino, Manabu D. Yamanaka, Shuichi Mori, Jun Matsumoto · 2017

We present a conceptual advance of the global water cycle in which the precipitation concentrated in tropical coastlines plays the role of an atmospheric dehydrator between the ocean and land. Landward water vapor transport peaks as it ent…

Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice Open

Manabu D. Yamanaka, Takanori Matsuura, Haili Pan, Min Zhuo · 2017

Long-term potentiation (LTP) of synaptic transmission in the central nervous system is a key form of cortical plasticity. The insular cortex (IC) is known to play important roles in pain perception, aversive memory and mood disorders. LTP …

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