M. Itoh
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View article: Fatal outcome after self-expanding transcatheter aortic valve replacement of the bicuspid valve due to infolding: a case report
Fatal outcome after self-expanding transcatheter aortic valve replacement of the bicuspid valve due to infolding: a case report Open
View article: Efficacy of the Preloading Coil-In-Plug Method for Internal Iliac Artery Embolization
Efficacy of the Preloading Coil-In-Plug Method for Internal Iliac Artery Embolization Open
The P-CIP technique enabled effective and reliable embolization of the IIA trunk and demonstrated advantages over conventional CE.
View article: Artificial blood vessels-clinical development of TEVG
Artificial blood vessels-clinical development of TEVG Open
The market for small-diameter vascular grafts (< 6 mm) used in cardiac and vascular surgery has not yet been fully established, as stable long-term patency has not been achieved. This paper focuses on the clinical development of tissue-eng…
View article: Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs
Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs Open
View article: Examining the Formalin Fixation Method for Maintaining High <scp>RNA</scp> Quality in Surgical Lung Specimens
Examining the Formalin Fixation Method for Maintaining High <span>RNA</span> Quality in Surgical Lung Specimens Open
Background Multiplex genetic testing is recommended when treating nonsmall cell lung cancer. A certain percentage of test failures in RNA assays owing to poor surgical specimen quality have been documented, and fixation failure is a possib…
View article: Characteristics of autumn phytoplankton communities in the Chukchi Sea: resuspension of settled diatoms diatoms to the surface during strong wind events
Characteristics of autumn phytoplankton communities in the Chukchi Sea: resuspension of settled diatoms diatoms to the surface during strong wind events Open
Phenological changes in microalgal production and community structure are occurring in the Arctic Ocean. In particular, delayed sea ice formation in autumn can extend the microalgal growth season; however, the succession of phytoplankton c…
View article: Rapidly Worsening Infective Endocarditis With Severe Mitral Stenosis
Rapidly Worsening Infective Endocarditis With Severe Mitral Stenosis Open
Infective endocarditis (IE) rarely results in mitral stenosis (MS), but MS in patients with IE can be life-threatening. We present a case of prosthetic MS secondary to IE. A 69-year-old Japanese man underwent mitral valve replacement with …
View article: Chimney thoracic endovascular aortic repair for traumatic aortic dissection with visceral malperfusion
Chimney thoracic endovascular aortic repair for traumatic aortic dissection with visceral malperfusion Open
A 73-year-old man was admitted to our hospital with a blunt thoracic aortic injury owing to a traffic accident. We diagnosed traumatic aortic dissection with visceral malperfusion requiring emergency thoracic endovascular aortic repair (TE…
Optical model potentials for deuteron scattering off and at Open
View article: Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs
Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs Open
Arthroplasty is currently the only option for reconstruction of large articular cartilage defects, mainly due to osteoarthritis. However, reconstruction with artificial materials has several issues such as deterioration, foreign body react…
View article: Novel Screening System for Biliary Excretion of Drugs Using Human Cholangiocyte Organoid Monolayers with Directional Drug Transport
Novel Screening System for Biliary Excretion of Drugs Using Human Cholangiocyte Organoid Monolayers with Directional Drug Transport Open
It has recently been reported that cholangiocyte organoids can be established from primary human hepatocytes. The purpose of this study was to culture the organoids in monolayers on inserts to investigate the biliary excretory capacity of …
View article: Immune Cell Kinetics after Allogeneic Red Blood Cell Transfusion in Patients Undergoing Cardiovascular Surgery
Immune Cell Kinetics after Allogeneic Red Blood Cell Transfusion in Patients Undergoing Cardiovascular Surgery Open
View article: Scaffold-free human vascular calcification model using a bio-three-dimensional printer
Scaffold-free human vascular calcification model using a bio-three-dimensional printer Open
Morbidity and mortality rates associated with atherosclerosis-related diseases are increasing. Therefore, developing new research models is important in furthering our understanding of atherosclerosis and investigate novel treatments. Here…
View article: Directional Drug Transport through Membrane-Supported Monolayers of Human Liver-Derived Cell Lines
Directional Drug Transport through Membrane-Supported Monolayers of Human Liver-Derived Cell Lines Open
The aim of this work is to develop a new assay system for screening biliary excretion drugs. When monolayers of human liver-derived cell lines HepG2 and Huh-7 were grown on an insert membrane, the efflux ratio (ER: ratio of the apparent pe…
View article: Impact of Blood Pressure Visit‐to‐Visit Variability on Adverse Events in Patients With Nonvalvular Atrial Fibrillation: Subanalysis of the J‐RHYTHM Registry
Impact of Blood Pressure Visit‐to‐Visit Variability on Adverse Events in Patients With Nonvalvular Atrial Fibrillation: Subanalysis of the J‐RHYTHM Registry Open
Background Blood pressure (BP) variability has reportedly been a risk factor for various clinical events. To clarify the influence of BP visit‐to‐visit variability on adverse events in patients with nonvalvular atrial fibrillation, a post …
View article: Correction: Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer
Correction: Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer Open
[This corrects the article DOI: 10.1371/journal.pone.0209162.].
View article: Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing
Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing Open
View article: Drug response analysis for scaffold-free cardiac constructs fabricated using bio-3D printer
Drug response analysis for scaffold-free cardiac constructs fabricated using bio-3D printer Open
Cardiac constructs fabricated using human induced pluripotent stem cells-derived cardiomyocytes (iPSCs-CMs) are useful for evaluating the cardiotoxicity of and cardiac response to new drugs. Previously, we fabricated scaffold-free three-di…
View article: Placement of a Zenith® Dissection Endovascular System in the Descending Thoracic Aorta Can Hamper Further Surgical Aortic Operations
Placement of a Zenith® Dissection Endovascular System in the Descending Thoracic Aorta Can Hamper Further Surgical Aortic Operations Open
Surgical operations for the aorta can become more difficult after bare stent placement in the aorta.
View article: Novel multi-layer plastic-scintillator-based solid active proton target for inverse-kinematics experiments
Novel multi-layer plastic-scintillator-based solid active proton target for inverse-kinematics experiments Open
We have constructed and tested a novel plastic-scintillator-based solid-state active proton target for use in nuclear spectroscopic studies with nuclear reactions induced by an ion beam in inverse kinematics. The active target system, name…
View article: Adult-onset primary Ewing’s sarcoma of the right atrium: a case report
Adult-onset primary Ewing’s sarcoma of the right atrium: a case report Open
We experienced an extremely rare case of primary cardiac Ewing's sarcoma in the right atrium of a 64-year-old man, which was successfully resected under cardiac arrest. Although the sarcoma was completely resected, postoperative chemothera…
View article: Publisher Correction: Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes
Publisher Correction: Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes Open
View article: 2-Cl-C.OXT-A stimulates contraction through the suppression of phosphodiesterase activity in human induced pluripotent stem cell-derived cardiac organoids
2-Cl-C.OXT-A stimulates contraction through the suppression of phosphodiesterase activity in human induced pluripotent stem cell-derived cardiac organoids Open
COA-Cl, which has neovascularization effects, suppressed PDE and increased the contraction of cardiac organoids, independent of S1P1R and A1R. These findings suggest that COA-Cl may be useful as an inotropic agent for promoting angiogenesi…
View article: Early and mid-term outcomes of total arch replacement with the frozen elephant trunk technique for type A acute aortic dissection
Early and mid-term outcomes of total arch replacement with the frozen elephant trunk technique for type A acute aortic dissection Open
OBJECTIVES The aim of this study was to evaluate the outcomes of the frozen elephant trunk (FET) technique, using the J Graft FROZENIX for Stanford type A acute aortic dissection, in comparison with the unfrozen elephant trunk technique. M…
View article: Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes
Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes Open
View article: Prolonged sinus arrest on electrocardiogram recording during apheresis donation in young female donor with convulsive syncope
Prolonged sinus arrest on electrocardiogram recording during apheresis donation in young female donor with convulsive syncope Open
Key Clinical Message An 18‐year‐old young female with a convulsive syncope during apheresis donation demonstrated a prolonged sudden sinus arrest continued for approximately 30‐second on monitor ECG. This prolonged sinus arrest may relate …
View article: 2-Cl-C.OXT-A Stimulates Contraction through the Suppression of Phosphodiesterase Activity in Human Induced Pluripotent Stem Cell-derived Cardiac Organoids
2-Cl-C.OXT-A Stimulates Contraction through the Suppression of Phosphodiesterase Activity in Human Induced Pluripotent Stem Cell-derived Cardiac Organoids Open
Background 2-Cl-C.OXT-A (COA-Cl) is a novel synthesized adenosine analog that activates S1P1 receptor (S1P1R) and combines with adenosine A1 receptor (A1R) in G proteins and was shown to enhance angiogenesis and improve the brain function …
View article: Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer
Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer Open
A major challenge in cardiac tissue engineering is the host's immune response to artificial materials. To overcome this problem, we established a scaffold-free system for assembling cell constructs using an automated Bio-3D printer. This p…
View article: Transapical thoracic endovascular aortic repair in aortic arch aneurysm through a pre-existent bioprosthetic aortic valve
Transapical thoracic endovascular aortic repair in aortic arch aneurysm through a pre-existent bioprosthetic aortic valve Open
An 80-year-old man had undergone Y-graft replacement for ruptured abdominal aortic aneurysm followed by bioprosthetic aortic valve replacement. Follow-up computed tomography revealed a 65-mm aneurysm at the distal aortic arch. We selected …
View article: Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment
Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment Open
Ability to form cellular aggregations such as tumorspheres and spheroids have been used as a morphological marker of malignant cancer cells and in particular cancer stem cells (CSC). However, the common definition of the types of cellular …