Manabu Sakaguchi
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View article: Transcriptome Analysis Identified <i>SPP1</i> ‐Positive Monocytes as a Key in Extracellular Matrix Formation in Thrombi
Transcriptome Analysis Identified <i>SPP1</i> ‐Positive Monocytes as a Key in Extracellular Matrix Formation in Thrombi Open
Background Thrombi follow various natural courses. They are known to become harder over time and may persist long term; some of them can also undergo early spontaneous dissolution and disappearance. Hindering thrombus stability may contrib…
View article: Acute Focal Bacterial Nephritis Caused by a Finger Penile Clamp for Voiding Postponemennt
Acute Focal Bacterial Nephritis Caused by a Finger Penile Clamp for Voiding Postponemennt Open
View article: Mechanical Thrombectomy for Methamphetamine-Associated Cardiomyopathy with Left Ventricular Thrombus: A Case Report
Mechanical Thrombectomy for Methamphetamine-Associated Cardiomyopathy with Left Ventricular Thrombus: A Case Report Open
Left ventricular thrombosis is relatively common in patients with MACM, necessitating careful consideration of the risk of cardioembolic stroke.
View article: Optimal antithrombotic therapy in ischemic stroke patients with non-valvular atrial fibrillation and atherothrombosis: study protocol for a randomized controlled trial
Optimal antithrombotic therapy in ischemic stroke patients with non-valvular atrial fibrillation and atherothrombosis: study protocol for a randomized controlled trial Open
Background The addition of antiplatelet therapy to anticoagulant therapy in patients with stroke with non-valvular atrial fibrillation (NVAF) and atherothrombotic disease may increase bleeding risk without reducing recurrent stroke risk. A…
View article: Case report: The histopathological analyses of two myelin oligodendrocyte glycoprotein antibody-associated diseases with a distinctive linear radiating gadolinium enhancement on MRI
Case report: The histopathological analyses of two myelin oligodendrocyte glycoprotein antibody-associated diseases with a distinctive linear radiating gadolinium enhancement on MRI Open
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has highly heterogeneous clinical presentations, in which encephalitis is an important phenotype. Moreover, MOGAD has been reported to exhibit diverse imaging findings…
View article: Transcriptome Analysis Identified<i>SPP1+</i>Monocytes as a Key in Extracellular Matrix Formation in Thrombi
Transcriptome Analysis Identified<i>SPP1+</i>Monocytes as a Key in Extracellular Matrix Formation in Thrombi Open
Thrombi follow various natural courses. They are known to become harder over time and may persist long-term; some of them can also undergo early spontaneous dissolution and disappearance. Hindering thrombus stability may contribute to the …
View article: Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis Which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-D-aspartate Receptor Encephalitis
Adult-onset Acute Flaccid Myelitis Accompanied by Rhombencephalitis Which First Presented with Prominent Psychiatric Symptoms and Dysautonomia Mimicking Anti-N-methyl-D-aspartate Receptor Encephalitis Open
A 44-year-old woman with a subacute onset of an altered mental status, urinary retention, and fluctuating blood pressure was initially diagnosed with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, meeting the criteria of Graus et…
View article: Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study
Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study Open
Background Patients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. We examined whether von Willebrand factor (vWF) a…
View article: Clinical characteristics of stroke in SARS-CoV-2 infected patients in Japan: A prospective nationwide study
Clinical characteristics of stroke in SARS-CoV-2 infected patients in Japan: A prospective nationwide study Open
View article: Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study
Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study Open
Background Limited data exist on the prognostic factors for patients with ischemic stroke and active cancer. Methods and Results We conducted a prospective, multicenter, observational study in Japan, including patients with acute ischemic …
View article: Predictors of survival in patients with ischemic stroke and active cancer: A prospective, multicenter, observational study
Predictors of survival in patients with ischemic stroke and active cancer: A prospective, multicenter, observational study Open
Background Patients with ischemic stroke and active cancer have a poor prognosis; however, supporting evidence remains limited. Methods We conducted a prospective, multicenter, observational study in Japan including patients with acute isc…
View article: Heterogeneity of Stroke in Patients with Systemic Lupus Erythematosus
Heterogeneity of Stroke in Patients with Systemic Lupus Erythematosus Open
Objective The underlying pathophysiology varies according to stroke subtype. However, stroke heterogeneity among patients with systemic lupus erythematosus (SLE) remains unstudied. We hypothesized that the contribution of SLE to stroke mig…
View article: Remote ischemic conditioning for acute ischemic stroke part 2: Study protocol for a randomized controlled trial
Remote ischemic conditioning for acute ischemic stroke part 2: Study protocol for a randomized controlled trial Open
Background Remote ischemic conditioning (RIC) refers to the application of repeated short periods of ischemia intended to protect remote areas against tissue damage during and after prolonged ischemia. Aim We aim to evaluate the efficacy o…
View article: A case of multiple systemic thrombosis including cerebral infarction associated with SARS-CoV-2, in which PCR test for SARS-CoV-2 was negative but antibody test was positive
A case of multiple systemic thrombosis including cerebral infarction associated with SARS-CoV-2, in which PCR test for SARS-CoV-2 was negative but antibody test was positive Open
生来健康な61歳男性.2020年9月X日(発症0日)より,全身倦怠感,呼吸苦を認めた.発症7日目の前医胸部CTでCOVID-19肺炎が疑われ,当センター救急診療科に転送されたが,SARS-CoV-2 PCR検査は陰性であった.発症8日目に応答が曖昧になり,発症10日目に右片麻痺が出現し当科に紹介.CTAで左MCA閉塞を認め,緊急血栓回収療法により再開通を得た.発症11日目に腎機能が悪化,造影CTで右腎動脈・肝動脈閉塞,大動脈壁在血栓,脾梗塞を認めた.右腎動脈閉塞に対し血管内…
View article: Author Correction: Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2
Author Correction: Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 Open
View article: Stroke Severity and Outcomes in Patients With Newly Diagnosed Atrial Fibrillation
Stroke Severity and Outcomes in Patients With Newly Diagnosed Atrial Fibrillation Open
Background and Purpose: Once a stroke occurs in a patient with atrial fibrillation (AF), it is likely to be severe. Patients with newly diagnosed AF after stroke and those with known AF before stroke have different background characteristi…
View article: Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2
Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 Open
View article: An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke
An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke Open
Background Thrombosis is a dynamic process, and a thrombus undergoes physical and biochemical changes that may alter its response to reperfusion therapy. This study assessed whether thrombus age influenced reperfusion quality and outcomes …
View article: Effect of Statin Administration After Onset of Acute Ischemic Stroke With Large Vessel Occlusion: Insights From RESCUE‐Japan Registry 2
Effect of Statin Administration After Onset of Acute Ischemic Stroke With Large Vessel Occlusion: Insights From RESCUE‐Japan Registry 2 Open
Background Statins have been associated with reduced recurrence and better functional outcomes in patients with acute ischemic stroke. However, the effect of statins in patients with acute large vessel occlusion (LVO) is not well scrutiniz…
View article: Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device
Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device Open
View article: Clinical Outcome of Patients With Large Vessel Occlusion and Low National Institutes of Health Stroke Scale Scores
Clinical Outcome of Patients With Large Vessel Occlusion and Low National Institutes of Health Stroke Scale Scores Open
Background and Purpose— The treatment and prognosis of acute large vessel occlusion with mild symptoms have not been sufficiently studied. The present study aimed to investigate the clinical or radiological predictors of clinical outcome i…
View article: Futile complete recanalization: patients characteristics and its time course
Futile complete recanalization: patients characteristics and its time course Open
View article: Magnetic Resonance Imaging Findings Related to Stroke Risk in Japanese Patients With Fabry Disease
Magnetic Resonance Imaging Findings Related to Stroke Risk in Japanese Patients With Fabry Disease Open
Background and Purpose— Stroke is the most frequent severe clinical event in patients with Fabry disease. We aimed to evaluate the cerebral magnetic resonance imaging findings of patients with Fabry disease and assess their association wit…
View article: Impact of Endovascular Therapy in Patients With Large Ischemic Core
Impact of Endovascular Therapy in Patients With Large Ischemic Core Open
Background and Purpose— Endovascular therapy (EVT) is strongly recommended for acute cerebral large vessel occlusion with the Alberta Stroke Program Early CT Score (ASPECTS) ≥6 due to occlusion of the internal carotid artery or M1 segment …
View article: A 9‐Year Longitudinal Study of Basilar Artery Diameter
A 9‐Year Longitudinal Study of Basilar Artery Diameter Open
Background Dilatation of the basilar artery ( BA ) has been recognized as a predictor of cardiovascular events ( CVE s). However, it is unclear if the longitudinal change in BA diameter (Δ BA ) is associated with CVE s. Methods and Results…
View article: β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke
β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke Open
Thrombin aggravates ischemic stroke and activated protein C (APC) has a neuroprotective effect. Both proteases interact with protease-activated receptor 1, which exhibits functional selectivity and leads to G-protein- and β-arrestin-mediat…
View article: Abstracts of the 38th Annual Meeting of the Japan Academy of Neurosonology (JAN)
Abstracts of the 38th Annual Meeting of the Japan Academy of Neurosonology (JAN) Open
discussed the following problems; selection of new committee members including technicians, details of the qualified examination, relationship with the qualification of the Japan Society of Ultrasonics in Medicine (JSUM), significance of t…
View article: Supplementary Material for: Successful Reperfusion with Endovascular Therapy Has Beneficial Effects on Long-Term Outcome Beyond 90 Days
Supplementary Material for: Successful Reperfusion with Endovascular Therapy Has Beneficial Effects on Long-Term Outcome Beyond 90 Days Open
Background and Purpose: Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term outcomes are not well known. We hyp…
View article: Endovascular Therapy in Ischemic Stroke With Acute Large‐Vessel Occlusion: Recovery by Endovascular Salvage for Cerebral Ultra‐Acute Embolism Japan Registry 2
Endovascular Therapy in Ischemic Stroke With Acute Large‐Vessel Occlusion: Recovery by Endovascular Salvage for Cerebral Ultra‐Acute Embolism Japan Registry 2 Open
Background Endovascular therapy has been shown to be effective in patients with acute cerebral large‐vessel occlusion, but real‐world efficacies are unknown. Methods and Results We conducted a prospective registry at 46 centers between Oct…
View article: Validation of an algorithm that determines stroke diagnostic code accuracy in a Japanese hospital-based cancer registry using electronic medical records
Validation of an algorithm that determines stroke diagnostic code accuracy in a Japanese hospital-based cancer registry using electronic medical records Open