Manabu Yasui
YOU?
Author Swipe
View article: Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene
Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene Open
View article: Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene
Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene Open
Numerous chemicals are associated with carcinogenesis through epigenetic alterations in cells. To detect global epigenetic changes induced by carcinogens, the housekeeping gene can serve as a reporter locus, offering a baseline for identif…
View article: Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualization
Deciphering repair pathways of clustered DNA damage in human TK6 cells: insights from atomic force microscopy direct visualization Open
Ionizing radiation induces various types of DNA damage, and the reparability and lethal effects of DNA damage differ depending on its spatial density. Elucidating the structure of radiation-induced clustered DNA damage and its repair proce…
View article: Crystal orientation of epitaxial film deposited on silicon surface
Crystal orientation of epitaxial film deposited on silicon surface Open
View article: Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair
Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair Open
Histone modifications are catalyzed and recognized by specific proteins to regulate dynamic DNA metabolism processes. NSD2 is a histone H3 lysine 36 (H3K36)-specific methyltransferase that associates both with various transcription regulat…
View article: Red Blood Cell Partitioning Using a Microfluidic Channel with Ladder Structure
Red Blood Cell Partitioning Using a Microfluidic Channel with Ladder Structure Open
This study investigated the partitioning characteristics of red blood cells (RBCs) within capillaries, with a specific focus on ladder structures observed near the end of the capillaries. In vitro experiments were conducted using microflui…
View article: Optical switch by direct modulated laser diode using fiber laser for pulse picking
Optical switch by direct modulated laser diode using fiber laser for pulse picking Open
A new method of direct modulating a pre‐amplifier laser diode as an optical switch is proposed. To modulate the laser diode with lower repetition rate, the repetition rate in the kilohertz region can be achieved using a source laser of 100…
View article: Carbon clusters on substrate surface for graphene growth- theoretical and experimental approach
Carbon clusters on substrate surface for graphene growth- theoretical and experimental approach Open
View article: Genotoxicity assessment of food-flavoring chemicals used in Japan
Genotoxicity assessment of food-flavoring chemicals used in Japan Open
View article: Effect of Plasma Irradiation on Hydrophilicity of Ni Plate
Effect of Plasma Irradiation on Hydrophilicity of Ni Plate Open
As described herein, this study examined the influence of a plasma irradiation on the deposit geometry of Ni-W on Ni. From FT-IR images, it became evident that hydroxyl improves the hydrophilic property of Ni. From XPS findings, we infer t…
View article: In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde
In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde Open
Background Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA reactive. Indeed, …
View article: Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™
Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™ Open
View article: Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS
Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS Open
Background Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using …
View article: Additional file 1 of Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™
Additional file 1 of Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™ Open
Additional file 1: Raw data for the Ames tests.
View article: Additional file 1 of Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS
Additional file 1 of Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS Open
Additional file 1.
View article: Additional file 3 of Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS
Additional file 3 of Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS Open
Additional file 3.
View article: Additional file 2 of Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS
Additional file 2 of Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS Open
Additional file 2.
View article: Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells
Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells Open
Ribonucleoside triphosphates are often incorporated into genomic DNA during DNA replication. The accumulation of unrepaired ribonucleotides is associated with genomic instability, which is mediated by DNA topoisomerase 1 (Top1) processing …
View article: Enhancing the sensitivity of the thymidine kinase assay by using <scp>DNA</scp> repair‐deficient human <scp>TK6</scp> cells
Enhancing the sensitivity of the thymidine kinase assay by using <span>DNA</span> repair‐deficient human <span>TK6</span> cells Open
The OECD guidelines define the bioassays of identifying mutagenic chemicals, including the thymidine kinase ( TK ) assay, which specifically detects the mutations that inactivate the TK gene in the human TK6 lymphoid line. However, the sen…
View article: Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η
Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η Open
DNA polymerases often incorporate non-canonical nucleotide, i.e., ribonucleoside triphosphates into the genomic DNA. Aberrant accumulation of ribonucleotides in the genome causes various cellular abnormalities. Here, we show the possible r…
View article: Comparative study of cytotoxic effects induced by environmental genotoxins using XPC- and CSB-deficient human lymphoblastoid TK6 cells
Comparative study of cytotoxic effects induced by environmental genotoxins using XPC- and CSB-deficient human lymphoblastoid TK6 cells Open
View article: Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η
Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η Open
DNA polymerases often incorporate non-canonical nucleotide, i.e., ribonucleoside triphosphates into the genomic DNA. Aberrant accumulation of ribonucleotides in the genome causes various cellular abnormalities. Here, we show the possible r…
View article: Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA
Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA Open
View article: Motility assessment of bovine sperm using microfluidic chips
Motility assessment of bovine sperm using microfluidic chips Open
View article: Challenges of young scientists at the cutting-edge of genotoxicity research: the open symposium of the Japanese Environmental Mutagen Society (JEMS), 2018
Challenges of young scientists at the cutting-edge of genotoxicity research: the open symposium of the Japanese Environmental Mutagen Society (JEMS), 2018 Open
The Open Symposium of the Japanese Environmental Mutagen Society (JEMS) entitled “Challenges of Young Scientists at the Cutting-edge of Genotoxicity Research” was held in the Main Conference Room of the Foundation for Promotion of Cancer R…
View article: The Time Dependency of Nano Hole Form for Al Nanoimprinting
The Time Dependency of Nano Hole Form for Al Nanoimprinting Open
View article: Removal of SU8 fine patterns with N-Methyl-2-Pyrrolidone doped
Removal of SU8 fine patterns with N-Methyl-2-Pyrrolidone doped Open
SU8 is a negative photoresist shows superior characteristics of heat resistance and chemical resistance. And, it is used to make high-aspect ratio micro structures such as master of electroforming. However, it is extremely difficult to rem…
View article: Removal of SU8 with N-Methyl-2-Pyrrolidone doped
Removal of SU8 with N-Methyl-2-Pyrrolidone doped Open
It is extremely difficult to remove SU8 from the substrate. Therefore, researchers have investigated oxygen plasma etching and wet ozone as a means of SU8 removal. However, oxygen plasma etching has unpleasant effect of antimony eliminatio…
View article: Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine
Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine Open
Numerous ribonucleotides are incorporated into the genome during DNA replication. Oxidized ribonucleotides can also be erroneously incorporated into DNA. Embedded ribonucleotides destabilize the structure of DNA and retard DNA synthesis by…
View article: Mutator Phenotype and DNA Double-Strand Break Repair in BLM Helicase-Deficient Human Cells
Mutator Phenotype and DNA Double-Strand Break Repair in BLM Helicase-Deficient Human Cells Open
Bloom syndrome (BS), an autosomal recessive disorder of the BLM gene, predisposes sufferers to various cancers. To investigate the mutator phenotype and genetic consequences of DNA double-strand breaks (DSBs) in BS cells, we developed BLM …