Manal A. Adam
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View article: Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals
Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals Open
Astrocyte specification during development is influenced by both intrinsic and extrinsic factors, but the precise contribution of each remains poorly understood. Here we show that mouse septal astrocytes derived from Nkx2.1 - and Zic4 -exp…
View article: α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex
α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex Open
View article: Multimodal classification of neurons in the lateral septum
Multimodal classification of neurons in the lateral septum Open
The lateral septum (LS) is a nucleus in the ventral forebrain that modulates complex social and affective behaviors. Several distinct neuronal types have been described in the LS; however, the full extent of this cellular and molecular div…
View article: Developmental origin and local signals cooperate to determine septal astrocyte identity
Developmental origin and local signals cooperate to determine septal astrocyte identity Open
Astrocyte specification during development is influenced by both intrinsic and extrinsic factors, but the precise contribution of each remains poorly understood. Here we show that septal astrocytes from Nkx2.1 and Zic4 expressing progenito…
View article: Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis
Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis Open
The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells…
View article: Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development
Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development Open
Neuron-glia interactions play a critical role in the regulation of synapse formation and circuit assembly. Here we demonstrate that canonical Sonic hedgehog (Shh) pathway signaling in cortical astrocytes acts to coordinate layer-specific s…
View article: Author response: Transcriptional profiling of sequentially generated septal neuron fates
Author response: Transcriptional profiling of sequentially generated septal neuron fates Open
View article: Transcriptional profiling of sequentially generated septal neuron fates
Transcriptional profiling of sequentially generated septal neuron fates Open
The septum is a ventral forebrain structure known to regulate innate behaviors. During embryonic development, septal neurons are produced in multiple proliferative areas from neural progenitors following transcriptional programs that are s…
View article: Astrocyte-Neuron Crosstalk Through Hedgehog Signaling Mediates Cortical Circuit Assembly
Astrocyte-Neuron Crosstalk Through Hedgehog Signaling Mediates Cortical Circuit Assembly Open
View article: Epigenetic regulation of cortical neurogenesis; orchestrating fate switches at the right time and place
Epigenetic regulation of cortical neurogenesis; orchestrating fate switches at the right time and place Open
View article: Impairments in sensory-motor gating and information processing in a mouse model of <i>Ehmt1</i> haploinsufficiency
Impairments in sensory-motor gating and information processing in a mouse model of <i>Ehmt1</i> haploinsufficiency Open
Regulators of chromatin dynamics and transcription are increasingly implicated in the aetiology of neurodevelopmental disorders. Haploinsufficiency of EHMT1, encoding a histone methyltransferase, is associated with several neurodevelopment…
View article: Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production
Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production Open
The mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, while inhibitory interneurons are generated in its v…
View article: Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production
Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production Open
SUMMARY The mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from progenitors located in the dorsal telencephalon, while inhibitory inte…
View article: Impairments in sensory-motor gating and information processing in a mouse model of <i>Ehmt1</i> haploinsufficiency
Impairments in sensory-motor gating and information processing in a mouse model of <i>Ehmt1</i> haploinsufficiency Open
Regulators of chromatin dynamics and transcription are increasingly implicated in the aetiology of neurodevelopmental disorders (NDDs). Haploinsufficiency of EHMT1 , encoding a histone methyl-transferase, is associated with several NDDs, i…
View article: EHMT1/GLP; Biochemical Function and Association with Brain Disorders
EHMT1/GLP; Biochemical Function and Association with Brain Disorders Open
The gene EHMT1 that encodes the Euchromatic Histone Methyltransferase-1, also known as GLP (G9a-like protein), has been associated with a number of neurodevelopmental and neurodegenerative disorders. GLP is a member of the euchromatic lysi…