Manali Mukherjee
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View article: Pearls from the European Academy of Allergy and Clinical Immunology (EAACI) Congress, 2025
Pearls from the European Academy of Allergy and Clinical Immunology (EAACI) Congress, 2025 Open
The European Academy of Allergy and Clinical Immunology (EAACI) Congress 2025, held in Glasgow, Scotland, United Kingdom from June 13 to 16, centred on the overarching theme of “Breaking boundaries in Allergy, Asthma, and Clinical Immunolo…
View article: Benralizumab reduces sputum ANCA in Patients with Eosinophilic Granulomatosis with Polyangiitis
Benralizumab reduces sputum ANCA in Patients with Eosinophilic Granulomatosis with Polyangiitis Open
View article: Neutrophilic asthma may not be a distinct endotype
Neutrophilic asthma may not be a distinct endotype Open
Sputum neutrophilia must take into account total cell counts to differentiate trivial versus intense neutrophilia. Various aberrant cellular mechanisms may increase susceptibility to airway infections, which consequently lead to …
View article: A novel method to assess airway eosinophilia utilizing sputum plugs
A novel method to assess airway eosinophilia utilizing sputum plugs Open
Background Sputum cytology utilizing routine dithiothreitol (DTT) processing is a well-established method to assess airway eosinophilia. However, the multi-step nature of this protocol requires substantial resources, thereby limiting its b…
View article: Sputum Cellularity and MRI Ventilation Defects in Severe Asthma
Sputum Cellularity and MRI Ventilation Defects in Severe Asthma Open
View article: Editorial: Women in science: allergy research
Editorial: Women in science: allergy research Open
View article: Reply to Correspondence: The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An <scp>EAACI</scp> Position Paper
Reply to Correspondence: The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An <span>EAACI</span> Position Paper Open
View article: Respiratory burden in post-acute COVID-19 sequelae: a longitudinal study of airway and systemic inflammation and clinical outcomes
Respiratory burden in post-acute COVID-19 sequelae: a longitudinal study of airway and systemic inflammation and clinical outcomes Open
Background It is unclear why patients with post-acute coronavirus disease 2019 sequelae (PACS) often present with persistent respiratory symptoms. We hypothesised that autoimmune inflammatory biomarkers may be associated with the persisten…
View article: Corrigendum: IL-18 biology in severe asthma
Corrigendum: IL-18 biology in severe asthma Open
[This corrects the article DOI: 10.3389/fmed.2024.1486780.].
View article: The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An <scp>EAACI</scp> Position Paper
The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An <span>EAACI</span> Position Paper Open
As cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long‐acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blockin…
View article: IL-18 biology in severe asthma
IL-18 biology in severe asthma Open
The role of interleukin-18 (IL-18) and inflammasomes in chronic inflammatory airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), has garnered significant attention in recent years. This review aims to provide …
View article: Up‐dosing of reslizumab in severe asthmatics with persistent sputum eosinophilia: A feasibility study
Up‐dosing of reslizumab in severe asthmatics with persistent sputum eosinophilia: A feasibility study Open
View article: Eosinophilic mucus diseases
Eosinophilic mucus diseases Open
Eosinophilic inflammation is primarily characterized by type 2 immune responses against parasitic organisms. In the contemporary human being especially in developed countries, eosinophilic inflammation is strongly associated with allergic/…
View article: Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals
Eosinophil-mucus interplay in severe asthma: Implications for treatment with biologicals Open
Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by sp…
View article: Eosinophils—from cradle to grave
Eosinophils—from cradle to grave Open
Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti‐inflammatory, regulatory). These versatile cells display both beneficial and…
View article: Sputum cytokines associated with raised FeNO after anti-IL5 biologic therapy in severe asthma.
Sputum cytokines associated with raised FeNO after anti-IL5 biologic therapy in severe asthma. Open
Sputum cytokines associated with raised FeNO after anti-IL5 biologic therapy in severe asthma.To the Editor,Biomarkers such as circulating absolute eosinophil count, % of eosinophils in sputum, and fraction of exhaled nitric oxide (FeNO) a…
View article: A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase
A Rapid Sputum‐based Lateral Flow Assay for Airway Eosinophilia using an RNA‐cleaving DNAzyme Selected for Eosinophil Peroxidase Open
The first protein‐binding allosteric RNA‐cleaving DNAzyme (RCD) obtained by direct in vitro selection against eosinophil peroxidase (EPX), a validated marker for airway eosinophilia, is described. The RCD has nanomolar affinity for EPX, sh…
View article: Eosinophil-independent IL-5 levels are increased in critically ill COVID-19 patients who survive
Eosinophil-independent IL-5 levels are increased in critically ill COVID-19 patients who survive Open
View article: A sputum bioassay for airway eosinophilia using an eosinophil peroxidase aptamer
A sputum bioassay for airway eosinophilia using an eosinophil peroxidase aptamer Open
Eosinophils are granulocytes that play a significant role in the pathogenesis of asthma and other airway diseases. Directing patient treatment based on the level of eosinophilia has been shown to be extremely effective in reducing exacerba…
View article: Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms
Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms Open
Background Autoimmunity has been reported in patients with severe COVID-19. We investigated whether antinuclear/extractable-nuclear antibodies (ANAs) were present up to a year after infection, and if they were associated with the developme…
View article: Impact of former smoking exposure on airway eosinophilic activation and autoimmunity in patients with severe asthma
Impact of former smoking exposure on airway eosinophilic activation and autoimmunity in patients with severe asthma Open
Introduction Severe eosinophilic asthma is characterised by frequent exacerbations and a relative insensitivity to steroids. Experimentally, smoking may induce eosinophilic airway inflammation, but the impact in patients with severe asthma…
View article: A unique CD27 - IgD - B-cells population in the sputum of severe eosinophilic asthma associated with airway autoimmunity
A unique CD27 - IgD - B-cells population in the sputum of severe eosinophilic asthma associated with airway autoimmunity Open
A unique CD27 -IgD -B-cells population was found to be significantly higher in number and proportion in the sputum of severe eosinophilic asthma, particularly the oral corticosteroid-dependent subgroup and might be related to a local autoi…
View article: Biologics in Asthma: A Molecular Perspective to Precision Medicine
Biologics in Asthma: A Molecular Perspective to Precision Medicine Open
Recent developments in therapeutic strategies have provided alternatives to corticosteroids as the cornerstone treatment for managing airway inflammation in asthma. The past two decades have witnessed a tremendous boost in the development …
View article: Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease
Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease Open
Background Excess pulmonary iron has been implicated in the pathogenesis of lung disease, including asthma and COPD. An association between higher iron content in sputum macrophages and infective exacerbations of COPD has previously been d…
View article: Benralizumab's anti-eosinophil efficacy may be decreased by impaired NK cell activity
Benralizumab's anti-eosinophil efficacy may be decreased by impaired NK cell activity Open
Although likely to be exceedingly rare, impaired ADCC due to NK cell dysfunction needs to be considered as one of the reasons, along with the development of anti-drug neutralising antibodies, for impaired anti-eosinophil activity of ben…
View article: Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections
Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections Open
Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated…
View article: Evidence of autoimmunity triggered by SARS-CoV-2 in acute and Post-acute COVID-19: a systematic literature review
Evidence of autoimmunity triggered by SARS-CoV-2 in acute and Post-acute COVID-19: a systematic literature review Open
Accumulating evidence suggest that autoimmune phenomena are frequent during Coronavirus Disease 2019 (COVID-19) and may lead to clinically overt disease. The breakdown of immune tolerance and/or impaired immune reconstitution after the ini…
View article: Lasting changes to circulating leukocytes in people with mild SARS-CoV-2 infections
Lasting changes to circulating leukocytes in people with mild SARS-CoV-2 infections Open
Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated…
View article: Underestimation of airway luminal eosinophilia by quantitative sputum cytometry
Underestimation of airway luminal eosinophilia by quantitative sputum cytometry Open
Rationale On Wright-stained sputum cytospins, eosinophil differential of ≥ 1.2% is considered abnormal, and ≥ 2.3% identifies an eosinophilic endotype. We hypothesized that failure to consider free eosinophil granules (FEG), and the re-eme…
View article: Notch4, uncovering an immunomodulator in allergic asthma
Notch4, uncovering an immunomodulator in allergic asthma Open
Title: Notch4, uncovering an immunomodulator in allergic asthmaAuthors: Beatriz Moyaa, Manali Mukherjeeb and Parameswaran Nairba. Department of Allergy, Hospital Universitario 12 de Octubre, Madrid, Spainb. Division of Respirology, Departm…