Manarangi De Silva
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View article: Sertraline use in pregnancy and placental transfer: A pharmacokinetic prospective cohort study
Sertraline use in pregnancy and placental transfer: A pharmacokinetic prospective cohort study Open
Introduction Depression in pregnancy is common and the use of antidepressants in pregnancy, especially sertraline, is on the rise. Although sertraline is known to cross the placenta, the level of transfer to the foetus is unclear. Thus, we…
View article: Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis
Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis Open
Background Metformin is a hypoglycaemic medication that has been proposed to treat or prevent preeclampsia. Combining national birth data from Scotland and Sweden, we investigated whether metformin used during pregnancy was associated with…
View article: Improving maternal and newborn health and reducing stillbirths in the Western Pacific Region – current situation and the way forward
Improving maternal and newborn health and reducing stillbirths in the Western Pacific Region – current situation and the way forward Open
Despite positive trends in many indicators, there remains an unacceptable burden of preventable maternal, newborn deaths and stillbirths every year. This paper provides an overview of the maternal and perinatal outcomes across 22 Pacific I…
View article: Incidence and causes of stillbirth in the only tertiary referral hospital in the Solomon Islands: a hospital-based retrospective cohort study
Incidence and causes of stillbirth in the only tertiary referral hospital in the Solomon Islands: a hospital-based retrospective cohort study Open
Objectives Stillbirth is a major global health issue, which disproportionately affects families living in low-income and middle-income countries. The Solomon Islands is a Pacific nation with poor perinatal outcomes, however research invest…
View article: Preventable stillbirth in the Solomon Islands -- a retrospective review
Preventable stillbirth in the Solomon Islands -- a retrospective review Open
Introduction: Stillbirth is a significant global public health issue, with approximately 98% occurring in low- and middle-income countries. The Solomon Islands is a Pacific nation with poor perinatal outcomes and very little previous resea…
View article: Severe maternal morbidity in the Asia Pacific: a systematic review and meta-analysis
Severe maternal morbidity in the Asia Pacific: a systematic review and meta-analysis Open
There is a high burden of severe maternal morbidity in the Asia-Pacific. LMICs are disproportionately affected. Most of the common causes are preventable. This provides an opportunity to implement targeted interventions which could have ma…
View article: Preventable stillbirths in the Solomon Islands – A hidden tragedy
Preventable stillbirths in the Solomon Islands – A hidden tragedy Open
View article: Prevalence and associations of small for gestational age in a cohort of women birthing in Honiara, the Solomon Islands.
Prevalence and associations of small for gestational age in a cohort of women birthing in Honiara, the Solomon Islands. Open
Background: Small for gestational age (SGA) is a significant indicator of subsequent neonatal and child morbidity. In low- and middle-income countries (LMICs), around a fifth of infants are born small for gestational age as defined by the …
View article: Systematic review of areca (betel nut) use and adverse pregnancy outcomes
Systematic review of areca (betel nut) use and adverse pregnancy outcomes Open
Background Betel nut is the fourth most commonly abused substance worldwide and has been associated with significant adverse health outcomes. Little is known about its effects on the fetus. Objective To perform a systematic review of studi…
View article: A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension
A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension Open
Background: Preeclampsia is a hypertensive disorder of pregnancy with a high rate of neonatal and maternal morbidity and mortality. The only definitive treatment is delivery. Through pre-clinical studies, proton pump inhibitors (PPIs), whi…