Manas Kohli
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View article: WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth
WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth Open
View article: Harnessing the Power of Metabolomics for Precision Oncology: Current Advances and Future Directions
Harnessing the Power of Metabolomics for Precision Oncology: Current Advances and Future Directions Open
Metabolic reprogramming is a hallmark of cancer, with cancer cells acquiring many unique metabolic traits to support malignant growth, and extensive intra- and inter-tumour metabolic heterogeneity. Understanding these metabolic characteris…
View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Summary:Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with a call to provide solutions to visualize tumor heterogeneity. The Rosetta team took on this challenge, exp…
View article: Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites
Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites Open
Voltage-gated sodium channel α-subunits (NaV1.1–1.9) initiate and propagate action potentials in neurons and myocytes. The NaV β-subunits (β1–4) have been shown to modulate α-subunit properties. Homo-oligomerization of β-subunits on neighb…
View article: Harnessing the Power of Metabolomics for Precision Oncology: Current Advances and Future Directions
Harnessing the Power of Metabolomics for Precision Oncology: Current Advances and Future Directions Open
Metabolic reprogramming is a hallmark of cancer, with cancer cells acquiring many unique met-abolic traits to support malignant growth, and extensive intra- and inter-tumour metabolic het-erogeneity. Understanding these metabolic character…
View article: Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites
Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites Open
Voltage-gated sodium channel beta-subunits (Nav1.1-1.9) initiate and propagate action potentials in neurons and myocytes. The Nav beta-subunits (beta1-4) have been shown to modulate beta-subunit properties. Homo-oligomerization of beta-sub…
View article: Pathological turret mutations in the cardiac sodium channel cause long-range pore disruption
Pathological turret mutations in the cardiac sodium channel cause long-range pore disruption Open
The voltage-gated sodium channel Nav1.5 initiates the cardiac action potential. Germline mutations that disrupt Nav1.5 activity predispose affected individuals to inherited cardiopathologies. Some of these Nav1.5 mutations alter amino acid…