Manasi Kelkar
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View article: Spatial and temporal signatures of cell competition revealed by K-function analysis
Spatial and temporal signatures of cell competition revealed by K-function analysis Open
It is generally hypothesised that in MDCK wild-type versus Scr KD co-cultures mechanical competition leads to the physical elimination of Scr KD cells, while in MDCK wild-type versus Ras V12 co-cultures biochemical competition results in t…
View article: OC 13.2 Improved Maturation of Human Pluripotent Stem Cell-Derived Endothelial Cells to Study Von Willebrand Factor Expression and Function
OC 13.2 Improved Maturation of Human Pluripotent Stem Cell-Derived Endothelial Cells to Study Von Willebrand Factor Expression and Function Open
indicative of a complex disorder with multiple genetic risk factors.Future replications and functionalization of variants will allow for a better characterization of these patients.
View article: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
Cell-generated forces play a major role in coordinating the large-scale behavior of cell assemblies, in particular during development, wound healing, and cancer. Mechanical signals propagate faster than biochemical signals, but can have si…
View article: Learning dynamic image representations for self-supervised cell cycle annotation
Learning dynamic image representations for self-supervised cell cycle annotation Open
Time-based comparisons of single-cell trajectories are challenging due to their intrinsic heterogeneity, autonomous decisions, dynamic transitions and unequal lengths. In this paper, we present a self-supervised framework combining an imag…
View article: Author response: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Author response: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
View article: Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane
Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane Open
The direction in which a cell divides is set by the orientation of its mitotic spindle and is important for determining cell fate, controlling tissue shape, and maintaining tissue architecture. Divisions parallel to the epithelial plane su…
View article: Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms
Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms Open
Proper orientation of the mitotic spindle plays a crucial role in embryos, during tissue development, and in adults, where it functions to dissipate mechanical stress to maintain tissue integrity and homeostasis. While mitotic spindles hav…
View article: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
Cell-generated forces play a major role in coordinating the large-scale behavior of cell assemblies, in particular during development, wound healing and cancer. Mechanical signals propagate faster than biochemical signals, but can have sim…
View article: Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms
Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms Open
Proper orientation of the mitotic spindle plays a crucial role in embryos, during tissue development, and in adults, where it functions to dissipate mechanical stress to maintain tissue integrity and homeostasis. While mitotic spindles hav…
View article: Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane
Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane Open
The direction in which a cell divides is set by the orientation of its mitotic spindle and is important for determining cell fate, controlling tissue shape and maintaining tissue architecture. Division perpendicular to the plane of the sub…
View article: Mechanics of the cellular actin cortex: From signalling to shape change
Mechanics of the cellular actin cortex: From signalling to shape change Open
View article: PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation
PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation Open
Cells couple growth with division and regulate size in response to nutrient availability. In rod-shaped fission yeast, cell-size control occurs at mitotic commitment. An important regulator is the DYRK-family kinase Pom1, which forms gradi…
View article: Environmental control of the Pom1-dependent cell-size regulation pathway in fission yeast
Environmental control of the Pom1-dependent cell-size regulation pathway in fission yeast Open
Cells couple their growth and division rate in response to nutrient availability to maintain a constant size. This co-ordination happens either at the G1-S or the G2-M transition of the cell cycle. In the rod-shaped fission yeast, size reg…