Manav Jain
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View article: Suppression of choroidal neovascularization by nonviral gene transfer of pigment epithelium-derived factor
Suppression of choroidal neovascularization by nonviral gene transfer of pigment epithelium-derived factor Open
Age-related macular degeneration (AMD), a leading cause of vision loss among individuals over 60, is characterized by progressive retinal degeneration in a critical area for vision, the macula, and neovascular complications. Pigment epithe…
View article: Immunomodulatory Delivery Materials for Tissue Repair
Immunomodulatory Delivery Materials for Tissue Repair Open
The immune system plays a critical role in the efficacy of regenerative medicine biotechnology, often mediated by delivery biomaterials. In this review, materials design approaches and challenges for the delivery of biomaterial platforms t…
View article: Antimicrobial prescription patterns in tertiary care centres in India: a multicentric point prevalence survey
Antimicrobial prescription patterns in tertiary care centres in India: a multicentric point prevalence survey Open
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View article: Transforming medical diagnosis: a comprehensive review of AI and ML technologies
Transforming medical diagnosis: a comprehensive review of AI and ML technologies Open
Artificial Intelligence (AI) and Machine Learning (ML) have emerged as transformative technologies in healthcare, particularly in medical diagnostics. This review explores the role of AI and ML in revolutionizing disease detection, treatme…
View article: Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis
Effect of Probiotics Supplementation on Cortisol Levels: A Systematic Review and Meta-Analysis Open
Background: Several randomized controlled trials (RCTs) have shown conflicting results on cortisol levels following probiotic administration in healthy and diseased populations. Previous analyses were inconclusive due to limited studies, a…
View article: Nanoparticle Targeting Strategies for Lipid and Polymer‐Based Gene Delivery to Immune Cells In Vivo
Nanoparticle Targeting Strategies for Lipid and Polymer‐Based Gene Delivery to Immune Cells In Vivo Open
Lipid nanoparticles and polymeric nanoparticles are promising biomaterial platforms for robust intracellular DNA and mRNA delivery, highlighted by the widespread use of nanoparticle‐ (NP) based mRNA vaccines to help end the COVID‐19 pandem…
View article: Meta-analysis using SPSS: a simple guide for clinicians, public health, and allied health specialists
Meta-analysis using SPSS: a simple guide for clinicians, public health, and allied health specialists Open
Systematic review and meta-analysis and other forms of evidence syntheses are critical to inform guideline development and healthcare decision-making. Various software is available now a days to conduct meta-analysis. Some of them are code…
View article: Discovery of Small‐Molecule Inhibitors Targeting Progranulin‐Sortilin: An in‐silico Approach Using Molecular Docking, Molecular Dynamics Simulations, and DFT Studies
Discovery of Small‐Molecule Inhibitors Targeting Progranulin‐Sortilin: An in‐silico Approach Using Molecular Docking, Molecular Dynamics Simulations, and DFT Studies Open
Introduction : Reduction in progranulin (PGRN) have been associated with various neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane transporter, resulting in its cellular uptake and eventual degradatio…
View article: Probiotics and Their Bioproducts: A Promising Approach for Targeting Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus
Probiotics and Their Bioproducts: A Promising Approach for Targeting Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus Open
Antibiotic resistance is a serious global health problem that poses a threat to the successful treatment of various bacterial infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistan…
View article: Discovery of novel small molecule inhibitors targeting progranulin-sortilin: A virtual high throughput screening approach
Discovery of novel small molecule inhibitors targeting progranulin-sortilin: A virtual high throughput screening approach Open
Introduction: Reduction in progranulin (PGRN) have been associated with various neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane transporter, resulting in its cellular uptake and eventual degradation…
View article: Machine Translation Systems for English Captions to Hindi Language Using Deep Learning
Machine Translation Systems for English Captions to Hindi Language Using Deep Learning Open
Machine Translation is the process of translating text from one language to another which helps to reduce the conversation gap among people from different cultural backgrounds. The task performed by the Machine Translation System is to aut…
View article: Novel therapeutic targets for amyotrophic lateral sclerosis
Novel therapeutic targets for amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is an untreatable and fatal neurodegenerative disease that is identified by the loss of motor neurons in the spinal cord, brain stem, and motor cortex which theatrically reduces life expectancy. Although…