Manchala Raghunath
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View article: The Diet–Obesity–Brain Axis: Metabolic, Epigenetic, and DNA-Repair Pathways Linking Eating Patterns to Cognitive Aging, with an AI-Enabled Translational Perspective
The Diet–Obesity–Brain Axis: Metabolic, Epigenetic, and DNA-Repair Pathways Linking Eating Patterns to Cognitive Aging, with an AI-Enabled Translational Perspective Open
Diet influences brain health through many connected metabolic and molecular pathways, and these effects are stronger in obesity. This review links diet quality with cognitive decline and dementia risk. Ultra-processed, high-fat, high-sugar…
View article: Tax – A Barrier to Public Health Care Access in India
Tax – A Barrier to Public Health Care Access in India Open
Access to pharmaceutical drugs is a cornerstone of public health and human welfare, particularly in a diverse and populous nation like India. Despite various government measures, such as the National List of Essential Medicines (NLEM), The…
View article: Interconnected Dynamics of ‘Obesageing’: Intricate Relationship Between Obesity and Ageing Processes
Interconnected Dynamics of ‘Obesageing’: Intricate Relationship Between Obesity and Ageing Processes Open
Background Obesity and ageing individually pose significant challenges to global public health, leading to preventable deaths. With an increasing geriatric population due to improved medical interventions, the intersection of these health …
View article: Exploring Therapeutic Potentials and Pathways of Psychedelics in Alzheimer’s Disease‐Related Dementia
Exploring Therapeutic Potentials and Pathways of Psychedelics in Alzheimer’s Disease‐Related Dementia Open
Background Traditionally associated with recreational and spiritual uses, psychedelics have gained attention in psychotherapy for their therapeutic potential. Functioning as potent 5‐hydroxytryptamine (5HT) agonists, these compounds have d…
View article: Navigating the Commonality of Healthcare Failures: COVID-19 and Conflict Zones
Navigating the Commonality of Healthcare Failures: COVID-19 and Conflict Zones Open
View article: Effect of Fenugreek Seeds and Its Bioactive Compounds on High Fructose High Fat Diet Induced Abnormalities in Sprague Dawley Rats
Effect of Fenugreek Seeds and Its Bioactive Compounds on High Fructose High Fat Diet Induced Abnormalities in Sprague Dawley Rats Open
Fenugreek seeds are rich in various essential compounds and these components play a significant role in healing and treating diseases by regulating several biological activities. The purpose of this study was to evaluate the metabolic effe…
View article: Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression
Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression Open
Major Depressive Disorder (MDD), colloquially known as depression, is a debilitating condition affecting an estimated 3.8% of the population globally, of which 5.0% are adults and 5.7% are above the age of 60. MDD is differentiated from co…
View article: Samaashraya: An Initiative to Address the COVID-19 and Pandemic-Related Psychosocial and Mental Health Concerns in India
Samaashraya: An Initiative to Address the COVID-19 and Pandemic-Related Psychosocial and Mental Health Concerns in India Open
View article: Current Status of Drug Targets and Emerging Therapeutic Strategies in the Management of Alzheimer's Disease
Current Status of Drug Targets and Emerging Therapeutic Strategies in the Management of Alzheimer's Disease Open
Alzheimer’s disease (AD) is a chronic neurodegenerative disease affecting the elderly. AD is associated with a progressive decline in memory and cognitive abilities, drastic changes in behavioural patterns and other psychiatric manifestati…
View article: Do Maternal Micronutrient Deficiencies Program the Body Composition and Behavior of the Offspring? Probable Underlying Mechanisms
Do Maternal Micronutrient Deficiencies Program the Body Composition and Behavior of the Offspring? Probable Underlying Mechanisms Open
Obesity and noncommunicable diseases (NCDs) like diabetes are epidemic in India. Developmental origins of health and disease hypothesis, based on epidemiological evidence, associates maternal undernutrition and low birth weight (LBW) of th…
View article: Recurring acute encephalitis syndrome outbreaks in Bihar, India
Recurring acute encephalitis syndrome outbreaks in Bihar, India Open
View article: ‘Obesageing’
‘Obesageing’ Open
Obesity is one of the leading causes of preventable mortalities in many parts of the globe. The rise in geriatric population due to better treatment opportunities has also emerged as a major public health challenge. Both of these health ch…
View article: Increased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose Diet
Increased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose Diet Open
Ageing is a universal, multifactorial phenomenon, determined by genetic and environmental factors such as diet, stress etc. Diet associated disorders are widely prevalent in India and have been attracting much attention and research in rec…
View article: Increased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose Diet
Increased Macromolecular Damage Underlies the Decreased Longevity of Wnin/Gr-Ob Rats Fed High Sucrose Diet Open
View article: Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging
Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging Open
DNA damage caused by various sources remains one of the most researched topics in the area of aging and neurodegeneration. Increased DNA damage causes premature aging. Aging is plastic and is characterised by the decline in the ability of …
View article: Severe but Not Moderate Vitamin B12 Deficiency Impairs Lipid Profile, Induces Adiposity, and Leads to Adverse Gestational Outcome in Female C57BL/6 Mice
Severe but Not Moderate Vitamin B12 Deficiency Impairs Lipid Profile, Induces Adiposity, and Leads to Adverse Gestational Outcome in Female C57BL/6 Mice Open
Vitamin B12 deficiency is widely prevalent in women of childbearing age, especially in developing countries. In the present study, through dietary restriction, we have established mouse models of severe and moderate vitamin B12 deficiencie…
View article: Anti-Hyperglycemic Activity of Camel Milk in Rat Models of Diabetes / Insulin Resistance
Anti-Hyperglycemic Activity of Camel Milk in Rat Models of Diabetes / Insulin Resistance Open
The anti-diabetic activity of camel milk in type 1 diabetics is attributed to the significant amounts of insulin / insulin like activity present in it.However, evidence for the anti-diabetic activity of camel milk is scanty and equivocal.T…
View article: Glucose and insulin AUC during oral glucose tolerance test.
Glucose and insulin AUC during oral glucose tolerance test. Open
Area Under Curves (AUC) of Glucose and insulin at different time points in Wistar rat male offspring fed different diets: Control (C), B12 restricted (B12R), B12 rehabilitation from conception (B12RC), B12 rehabilitation from parturition (…
View article: Effect of Chromium(III) -Amino acid (1:3)Complexes on High Sucrose Induced Insulin Resistance, Lipid Abnormalities and Oxidative Stress in Male Sprague Dawley Rats
Effect of Chromium(III) -Amino acid (1:3)Complexes on High Sucrose Induced Insulin Resistance, Lipid Abnormalities and Oxidative Stress in Male Sprague Dawley Rats Open
This study was carried out to assess the anti-hyperglycaemic effects if any of novel synthetic binary chromium (III)-amino acid complexes in a high sucrose (HS) induced insulin resistance (IR) and or impaired glucose tolerant male Sprague …