Manchun Wang
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View article: A Groundbreaking Electric Field‐Induced Cascade Gas Therapy Against Large Volume Solid Tumor Through Electro‐Stress Storm
A Groundbreaking Electric Field‐Induced Cascade Gas Therapy Against Large Volume Solid Tumor Through Electro‐Stress Storm Open
Gas therapy has been limited in its application as a robust standalone antitumor strategy due to the restricted gas production and cytotoxicity. To address this challenge, we employed electrotoxic PtRu composite metal nano‐berries (PR) loa…
View article: Chloroplast state transitions modulate nuclear genome stability via cytokinin signaling in Arabidopsis
Chloroplast state transitions modulate nuclear genome stability via cytokinin signaling in Arabidopsis Open
Activities of the chloroplasts and nucleus are coordinated by retrograde signaling, which play crucial roles in plant development and environmental adaptation. However, the connection between chloroplast status and nuclear genome stability…
View article: Overcoming the Tumor Collagen Barriers: A Multistage Drug Delivery Strategy for DDR1‐Mediated Resistant Colorectal Cancer Therapy
Overcoming the Tumor Collagen Barriers: A Multistage Drug Delivery Strategy for DDR1‐Mediated Resistant Colorectal Cancer Therapy Open
The extracellular matrix (ECM) is critical for drug resistance in colorectal cancer (CRC). The abundant collagen within the ECM significantly influences tumor progression and matrix‐mediated drug resistance (MMDR) by binding to discoidin d…
View article: Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune Responses for Potentiated Colorectal Cancer Treatment
Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune Responses for Potentiated Colorectal Cancer Treatment Open
The intestinal and intratumoral microbiota are closely associated with tumor progression and response to antitumor treatments. The antibacterial or tumor microenvironment (TME)-modulating approaches have been shown to markedly improve anti…