Mandana Mansouri
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View article: Human cytomegalovirus UL18 prevents priming of MHC-E– and MHC-II–restricted CD8 <sup>+</sup> T cells
Human cytomegalovirus UL18 prevents priming of MHC-E– and MHC-II–restricted CD8 <sup>+</sup> T cells Open
Rhesus cytomegalovirus (RhCMV) vectors elicit major histocompatibility complex (MHC)–E–restricted CD8 + T cells that stringently control simian immunodeficiency virus (SIV) in rhesus macaques. These responses require deletion of eight RhCM…
View article: CD8 <sup>+</sup> T cell targeting of tumor antigens presented by HLA-E
CD8 <sup>+</sup> T cell targeting of tumor antigens presented by HLA-E Open
The nonpolymorphic major histocompatibility complex E (MHC-E) molecule is up-regulated on many cancer cells, thus contributing to immune evasion by engaging inhibitory NKG2A/CD94 receptors on NK cells and tumor-infiltrating T cells. To inv…
View article: MHC-E–Restricted CD8+ T Cells Target Hepatitis B Virus–Infected Human Hepatocytes
MHC-E–Restricted CD8+ T Cells Target Hepatitis B Virus–Infected Human Hepatocytes Open
Currently 247 million people are living with chronic hepatitis B virus infection (CHB), and the development of novel curative treatments is urgently needed. Immunotherapy is an attractive approach to treat CHB, yet therapeutic approaches t…
View article: Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors
Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors Open
Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricte…