Ming-Cheng Chan
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View article: Non-cystic fibrosis bronchiectasis in Taiwan
Non-cystic fibrosis bronchiectasis in Taiwan Open
Introduction Bronchiectasis exhibits substantial heterogeneity across geographic locations and includes a diverse range of aetiologies. Limited large-scale data are available for Southeast Asian countries. Methods This was a multicentre, r…
View article: Cardiovascular disease as a prognostic factor for mortality in non-cystic fibrosis bronchiectasis: data from the Taiwan Bronchiectasis Research Collaboration
Cardiovascular disease as a prognostic factor for mortality in non-cystic fibrosis bronchiectasis: data from the Taiwan Bronchiectasis Research Collaboration Open
Background Non-cystic fibrosis bronchiectasis (NCFB) is linked to an increased incidence of cardiovascular disease (CVD), but its impact on mortality is unclear. This study aimed to assess the effect of CVD on mortality and its relationshi…
View article: PaCO2 responders of prone positioning in acute respiratory distress syndrome had better survival rates: A multicenter cohort study in Taiwan
PaCO2 responders of prone positioning in acute respiratory distress syndrome had better survival rates: A multicenter cohort study in Taiwan Open
In this multicenter retrospective cohort study of patients with ARDS receiving prone positioning, PaCO2 responders had better clinical outcomes than PaCO2 non-responders.
View article: Early fungal colonization and infection as an independent predictor of in-hospital mortality in mechanically ventilated COVID-19 patients: A nationwide target trial emulation study in Taiwan
Early fungal colonization and infection as an independent predictor of in-hospital mortality in mechanically ventilated COVID-19 patients: A nationwide target trial emulation study in Taiwan Open
"Early" fungal colonization and infection within 10 days of corticosteroid initiation is an independent risk factor for in-hospital mortality in mechanically ventilated COVID-19 patients. Future research should explore early intervention s…
View article: The impact of COPD–bronchiectasis association on clinical outcomes: insights from East Asian cohorts validating the ROSE criteria
The impact of COPD–bronchiectasis association on clinical outcomes: insights from East Asian cohorts validating the ROSE criteria Open
Background The radiology, obstruction, symptoms and exposure (ROSE) criteria provide a standardised approach for identifying the “COPD–bronchiectasis (BE) association.” However, the clinical implications and outcomes of the COPD–BE associa…
View article: Clinical significance of respiratory bacteria and mycobacteria isolates in adult bronchiectasis in Taiwan
Clinical significance of respiratory bacteria and mycobacteria isolates in adult bronchiectasis in Taiwan Open
Background The clinical impact of bacterial and mycobacterial isolates on bronchiectasis remains uncertain. Methods Patients with bronchiectasis at 16 hospitals in Taiwan were recruited with a 1-year follow-up. The patients were classified…
View article: A real-world study to evaluate effectiveness of mepolizumab in treating severe asthma in Taiwan (REMIT)
A real-world study to evaluate effectiveness of mepolizumab in treating severe asthma in Taiwan (REMIT) Open
Background: REMIT is the first real-world study of mepolizumab effectiveness in patients with severe asthma (SA) in Taiwan. Objectives: The primary objective evaluated changes in clinically significant exacerbations (CSEs; defined as use o…
View article: Benefit of dual bronchodilator therapy on exacerbations in former and current smokers with chronic obstructive pulmonary disease in real-world clinical practice: a multicenter validation study (TOReTO)
Benefit of dual bronchodilator therapy on exacerbations in former and current smokers with chronic obstructive pulmonary disease in real-world clinical practice: a multicenter validation study (TOReTO) Open
The three fixed-dose combinations of LABA/LAMA showed no difference in reducing exacerbations in former smokers but did show differences in current smokers. This trend has clinical significance, and future research will be conducted to con…
View article: Clinical Predictors of Nontuberculous Mycobacteria Lung Disease and Coisolates of Potential Pathogenic Microorganisms in Noncystic Fibrosis Bronchiectasis
Clinical Predictors of Nontuberculous Mycobacteria Lung Disease and Coisolates of Potential Pathogenic Microorganisms in Noncystic Fibrosis Bronchiectasis Open
Background In bronchiectasis, nontuberculous mycobacteria (NTM) lung disease (NTM-LD) is a well-known coexisting infection. However, microorganism coisolates and clinical NTM-LD predictors are poorly studied. Methods Patients with bronchie…
View article: Pamrevlumab for Idiopathic Pulmonary Fibrosis
Pamrevlumab for Idiopathic Pulmonary Fibrosis Open
Importance Current treatments for idiopathic pulmonary fibrosis slow the rate of lung function decline, but may be associated with adverse events that affect medication adherence. In phase 2 trials, pamrevlumab (a fully human monoclonal an…
View article: Risk factors for prolonged mechanical ventilation in critically ill patients with influenza-related acute respiratory distress syndrome
Risk factors for prolonged mechanical ventilation in critically ill patients with influenza-related acute respiratory distress syndrome Open
BackgroundPatients with influenza-related acute respiratory distress syndrome (ARDS) are critically ill and require mechanical ventilation (MV) support. Prolonged mechanical ventilation (PMV) is often seen in these cases and the optimal ma…
View article: The Association Between Absolute Lymphocyte Count and Long-Term Mortality in Critically Ill Medical Patients: Propensity Score-Based Analyses
The Association Between Absolute Lymphocyte Count and Long-Term Mortality in Critically Ill Medical Patients: Propensity Score-Based Analyses Open
We found that low ALC was associated with long-term mortality in critically ill patients; further studies are warranted to validate and translate these findings into clinical utility.
View article: Association between early blood urea nitrogen-to-albumin ratio and one-year post-hospital mortality in critically ill surgical patients: a propensity score-matched study
Association between early blood urea nitrogen-to-albumin ratio and one-year post-hospital mortality in critically ill surgical patients: a propensity score-matched study Open
Background Blood urea nitrogen to albumin ratio (BAR) is increasingly recognized as an early predictor for short-term outcomes in critically ill patients, but the association of BAR with long-term outcomes in critically ill surgical patien…
View article: Explainable machine learning approach to predict extubation in critically ill ventilated patients: a retrospective study in central Taiwan
Explainable machine learning approach to predict extubation in critically ill ventilated patients: a retrospective study in central Taiwan Open
Background Weaning from mechanical ventilation (MV) is an essential issue in critically ill patients, and we used an explainable machine learning (ML) approach to establish an extubation prediction model. Methods We enrolled patients who w…
View article: Incidence and Outcomes of Acute Respiratory Distress Syndrome – Experience of a Medical Center in Taiwan
Incidence and Outcomes of Acute Respiratory Distress Syndrome – Experience of a Medical Center in Taiwan Open
Background: Acute respiratory distress syndrome (ARDS) is a common life-threatening condition in critically ill patients. It is also an important public health issue because it can cause substantial mortality and health care burden worldwi…
View article: The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study
The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study Open
Background The importance or necessity of a loading dose when prescribing intravenous colistin has not been well established in clinical practice, and approximate one-third to half of patients with carbapenem-resistant gram-negative bacter…
View article: Comparing Clinical Outcomes of Tiotropium/Olodaterol, Umeclidinium/Vilanterol, and Indacaterol/Glycopyrronium Fixed-Dose Combination Therapy in Patients with Chronic Obstructive Pulmonary Disease in Taiwan: A Multicenter Cohort Study
Comparing Clinical Outcomes of Tiotropium/Olodaterol, Umeclidinium/Vilanterol, and Indacaterol/Glycopyrronium Fixed-Dose Combination Therapy in Patients with Chronic Obstructive Pulmonary Disease in Taiwan: A Multicenter Cohort Study Open
This study presented valuable real-world outcome in terms of exacerbation and treatment response of COPD patients treated with fixed-dose LABA/LAMA regimens in Taiwan. The annualized rates of moderate-to-severe exacerbation in patients rec…
View article: Predictors of a Minimal Clinically Important Difference Following Omalizumab Treatment in Adult Patients With Severe Allergic Asthma
Predictors of a Minimal Clinically Important Difference Following Omalizumab Treatment in Adult Patients With Severe Allergic Asthma Open
Several factors have been found to be predictors of a good response following omalizumab treatment in patients with severe allergic asthma (SAA). However, it remains unclear whether clinical characteristics can predict a minimal clinically…
View article: Artificial intelligence–aided diagnosis model for acute respiratory distress syndrome combining clinical data and chest radiographs
Artificial intelligence–aided diagnosis model for acute respiratory distress syndrome combining clinical data and chest radiographs Open
Objective The aim of this study was to develop an artificial intelligence–based model to detect the presence of acute respiratory distress syndrome (ARDS) using clinical data and chest X-ray (CXR) data. Method The transfer learning method …
View article: Impact of Comorbidities on Beneficial Effect of Lactated Ringers vs. Saline in Sepsis Patients
Impact of Comorbidities on Beneficial Effect of Lactated Ringers vs. Saline in Sepsis Patients Open
Background: Lactated Ringers reduced mortality more than saline in sepsis patients but increased mortality more than saline in traumatic brain injury patients. Method: This prospective cohort study was conducted in a medical intensive care…
View article: Comparison of prone positioning and extracorporeal membrane oxygenation in acute respiratory distress syndrome: A multicenter cohort study and propensity-matched analysis
Comparison of prone positioning and extracorporeal membrane oxygenation in acute respiratory distress syndrome: A multicenter cohort study and propensity-matched analysis Open
While the patients receiving prone positioning had better outcome, the causality between prone positioning and the prognosis is unknown. However, the current data suggested that patients with influenza-related ARDS may receive prone positi…