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View article: Clinical Efficacy of One Short Course of Mannan-Conjugated Birch Pollen Allergoid Immunotherapy: A Comparative Evaluation After Prior Placebo Treatment
Clinical Efficacy of One Short Course of Mannan-Conjugated Birch Pollen Allergoid Immunotherapy: A Comparative Evaluation After Prior Placebo Treatment Open
Background/Objectives: Allergen immunotherapy (AIT) with chemically modified allergoids represents a promising approach for the treatment of allergic rhinoconjunctivitis. This post hoc analysis investigated the clinical efficacy of a manna…
View article: #3377 Not everything is diabetic nephropathy. Analysis of kidney biopsies in type 2 diabetic patients on a 15-year-old cohort
#3377 Not everything is diabetic nephropathy. Analysis of kidney biopsies in type 2 diabetic patients on a 15-year-old cohort Open
Background and Aims There are predictive models that guide the performance of renal biopsy in diabetic patients in whom there is no clear relationship between kidney pathology and diabetes mellitus. The García-Martín score assigns a score …
View article: Three-Year Outcomes After Temperature-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Chronic Rhinitis
Three-Year Outcomes After Temperature-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Chronic Rhinitis Open
Background Chronic rhinitis (CR) is characterized by refractory symptoms such as rhinorrhea, sneezing, nasal congestion, postnasal drip (PND), and cough. Most patients do not achieve lasting symptom relief with medical management. Objectiv…
View article: Multi-centric real-world effectiveness of mepolizumab in severe chronic rhinosinusitis with nasal polyps in Germany
Multi-centric real-world effectiveness of mepolizumab in severe chronic rhinosinusitis with nasal polyps in Germany Open
Background: Within the last years, monoclonal antibodies (biologicals) have revolutionized the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) and significantly improved symptom control in otherwise refractory cases. The eff…
View article: Otitis Media With Effusion (<scp>OME</scp>) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An <scp>EAACI</scp> Position Paper
Otitis Media With Effusion (<span>OME</span>) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity—An <span>EAACI</span> Position Paper Open
IgE‐mediated allergies play a significant role in respiratory diseases. Given the similar mucosal epithelium of the upper and lower respiratory tracts and their shared (patho)physiological immune responses, the “unified airways” concept vi…
View article: Treatment and Outcome of Anaphylactic Reactions in Emergency Medical Services of Dresden/Germany: A 5-Year Analysis
Treatment and Outcome of Anaphylactic Reactions in Emergency Medical Services of Dresden/Germany: A 5-Year Analysis Open
Introduction: Anaphylactic reactions can lead to life-threatening situations. Therefore, a rapid diagnosis and therapy are indicated. Various guidelines recommend immediate treatment with intramuscular adrenaline in severe anaphylaxis. Bas…
View article: Pivotal role of the optimal dose in allergen immunotherapy
Pivotal role of the optimal dose in allergen immunotherapy Open
The transitioning of named patient products (NPPs) of therapy allergens is regulated under the German therapy allergen ordinance (TAO) since 2008. The establishment of a sound dose–response relationship constitutes a pivotal aspect in clin…
View article: Short‐course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy
Short‐course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy Open
Background Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of the mannan‐conjugated birch pollen polymerized allergoid T502 in birch pollen‐induced allergi…
View article: Real‐world data show sustained therapeutic effects of dupilumab in chronic rhinosinusitis with nasal polyps (<scp>CRSwNP</scp>) over 3 years
Real‐world data show sustained therapeutic effects of dupilumab in chronic rhinosinusitis with nasal polyps (<span>CRSwNP</span>) over 3 years Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent chronic inflammatory condition affecting the nose and paranasal sinuses, posing a significant socio‐economic impact with substantial challenges in management. Biol…
View article: Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps
Evaluation of ongoing mepolizumab treatment in chronic rhinosinusitis with nasal polyps Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and paranasal sinuses. Eosinophilic inflammation is described as a common endotype. The anti-interleukin-5 (IL-5…
View article: Efficacy and safety of the combination nasal spray olopatadine hydrochloride-mometasone furoate in the treatment of allergic rhinitis
Efficacy and safety of the combination nasal spray olopatadine hydrochloride-mometasone furoate in the treatment of allergic rhinitis Open
Introduction Pharmacotherapy is the main pillar in the treatment of allergic rhinitis. While antihistamines (AH) and intranasal glucocorticosteroids (INCS) have long been part of the therapeutic standard, a pharmacological combination of b…
View article: Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy?
Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy? Open
Understanding the immunological basis of CRSwNP opens up new non-surgical therapeutic approaches with biologics for patients with severe, uncontrolled courses. Here, we provide recommendations for follow-up, adherence to therapy intervals,…
View article: EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP)
EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP) Open
Characterization of mucosal airway inflammation through biomarker determination is meaningful and occasionally makes the difference for targeted therapy.
View article: Eosinophil granulocytes in chronic inflammatory respiratory diseases and CRSwNP: Function, immunological basis, and clinical significance
Eosinophil granulocytes in chronic inflammatory respiratory diseases and CRSwNP: Function, immunological basis, and clinical significance Open
The important role of eosinophils in immunological processes in the airway mucosa is comprehensively analyzed and can serve as a basis for current and future treatment approaches.
View article: Two‐Year Outcomes After Radiofrequency Neurolysis of Posterior Nasal Nerve in Chronic Rhinitis
Two‐Year Outcomes After Radiofrequency Neurolysis of Posterior Nasal Nerve in Chronic Rhinitis Open
Objective To assess the long‐term safety and effectiveness of temperature‐controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), a minimally invasive treatment for chronic rhinitis. Methods A prospective, single‐ar…
View article: A randomized, double‐blind, placebo‐controlled trial with mannan‐conjugated birch pollen allergoids
A randomized, double‐blind, placebo‐controlled trial with mannan‐conjugated birch pollen allergoids Open
Background There is still great need to develop new strategies to improve the efficacy of allergen immunotherapies with optimal safety standards for patients. A new promising approach is to couple allergoids to mannan. The objective of thi…
View article: Short‐course subcutaneous treatment with PQ Grass strongly improves symptom and medication scores in grass allergy
Short‐course subcutaneous treatment with PQ Grass strongly improves symptom and medication scores in grass allergy Open
Background A modified grass allergen subcutaneous immunotherapy (SCIT) product with MicroCrystalline Tyrosine and monophosphoryl lipid‐A as an adjuvant system (Grass MATA MPL [PQ Grass]) is being developed as short‐course treatment of gras…
View article: Correlations between gustatory, trigeminal, and olfactory functions and nasal airflow
Correlations between gustatory, trigeminal, and olfactory functions and nasal airflow Open
Purpose To determine the relationship of chemosensory screening and nasal airflow tests among the same set of participants, and to determine other factors that are related to the outcomes of these tests. Methods Participants had no chemose…
View article: Allergen immunotherapy in house dust mite-associated allergic rhinitis: efficacy of the 300 IR mite tablet
Allergen immunotherapy in house dust mite-associated allergic rhinitis: efficacy of the 300 IR mite tablet Open
Background A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life of patients and is associated with a high socioeconomic burden. The most common symptoms of allergic rhinitis include a runny nos…
View article: Avoidance measures for mite allergy—an update
Avoidance measures for mite allergy—an update Open
House dust mites are a major source of allergens in house dust and, thus, the main trigger of perennial allergic respiratory diseases [1–5]. Scientific research on the life cycle, diet, and reproductive behavior of dust mites and on the bi…
View article: Trigeminal Sensitivity in Patients With Allergic Rhinitis and Chronic Rhinosinusitis
Trigeminal Sensitivity in Patients With Allergic Rhinitis and Chronic Rhinosinusitis Open
Objective Allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP) are of high importance in otorhinolaryngology. Some of their symptoms are related to changes in the nasal trigeminal sensitivity. The aim of this study …
View article: Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP)
Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP) Open
Summary Background Chronic rhinosinusitis with nasal polyps (CRSwNP), an inflammatory disease of the paranasal mucosa, is primarily characterized by type 2 inflammation. Three antibodies (dupilumab, omalizumab, and mepolizumab) are now app…