Explanipedia

Rebalancing the motor circuit restores movement in a Caenorhabditis elegans model for TDP-43 toxicity Open

Mandy Koopman, Lale Güngördü, Leen Janssen, Renée I. Seinstra, Janet E. Richmond , et al. · 2024

Amyotrophic lateral sclerosis can be caused by abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. Here, we use a C. elegans model for TDP-43-induced toxicity to identify the biological mechanisms that…

Rebalancing the motor circuit restores movement in a<i>Caenorhabditis elegans</i>model for TDP-43-toxicity Open

Mandy Koopman, Lale Güngördü, Leen Janssen, Renée I. Seinstra, Janet E. Richmond , et al. · 2023

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia are caused by the abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. How TDP-43 accumulation leads to disease symptoms is not well-chara…

Neuronal overexpression of human TDP-43 in Caenorhabditis elegans causes a range of sensorimotor phenotypes Open

Mandy Koopman, Lale Güngördü, Renée I. Seinstra, Ellen A. A. Nollen · 2023

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies Open

Mandy Koopman, Lale Güngördü, Renée I. Seinstra, Wytse Hogewerf, Ellen A. A. Nollen · 2023

Inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a characteristic feature of amyotrophic lateral sclerosis (ALS). Caenorhabditis elegans has been instrumental in studying the underlying mechanisms of…

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs different neuronally controlled behaviors and decreases fecundity Open

Mandy Koopman, Lale Güngördü, Renée I. Seinstra, Ellen A. A. Nollen · 2023

Cytoplasmic inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a key hallmark of TDP-43 proteinopathies like amyotrophic lateral sclerosis (ALS). Caenorhabditis elegans is considered a useful model for…

Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs motor function Open

Mandy Koopman, Lale Güngördü, Renée I. Seinstra, Ellen A. A. Nollen · 2023

Transactive response DNA binding-protein 43 (TDP-43) is a conserved RNA/DNA-binding protein with a role in RNA metabolism and homeostasis. Aberrant TDP-43 functioning has been considered a major culprit in amyotrophic lateral sclerosis (AL…

Rebalancing the Motor Circuit Restores Movement in a Caenorhabditis elegans Model for TDP-43 Toxicity Open

Mandy Koopman, Lale Güngördü, Leen Janssen, Renée I. Seinstra, Janet E. Richmond , et al. · 2023

From cellular vulnerability to altered circuit activity Open

Mandy Koopman · 2022

The devastating effects of the brain losing its ability to control voluntary body movement are illustrated by diseases such as amyotrophic lateral sclerosis (ALS) - where the nerve cells that allow the brain to effectively communicate with…

Supplementary data Thesis Mandy Koopman Open

Mandy Koopman · 2022

Supplementary data chapter 7,8 and 9.

Supplementary data Thesis Mandy Koopman Open

Mandy Koopman · 2022

Supplementary data chapter 7,8 and 9.

The cellular modifier MOAG‐4/SERF drives amyloid formation through charge complementation Open

Anita Pras, Bert Houben, Francesco A. Aprile, Renée I. Seinstra, Rodrigo Gallardo , et al. · 2021

Publisher Correction to: An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans Open

Mandy Koopman, Leen Janssen, Ellen A. A. Nollen · 2021

An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans Open

Mandy Koopman, Leen Janssen, Ellen A. A. Nollen · 2021

Optogenetic manipulation of individual or whole population<i>Caenorhabditis elegans</i>worms with an under hundred-dollar tool: the OptoArm Open

Mandy Koopman, Leen Janssen, Ellen A. A. Nollen · 2021

Optogenetic tools have revolutionized the study of neuronal circuits in Caenorhabditis elegans. The expression of light-sensitive ion channels or pumps under specific promotors allows researchers to modify the behavior of excitable cells. …

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation Open

Anita Pras, Bert Houben, Francesco A. Aprile, Renée I. Seinstra, Rodrigo Gallardo , et al. · 2020

While aggregation-prone proteins are known to accelerate ageing and cause age-related diseases, the cellular mechanisms that drive their cytotoxicity remain unresolved. The orthologous proteins MOAG-4, SERF1A and SERF2 have recently been i…

Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform Open

Mandy Koopman, Quentin Peter, Renée I. Seinstra, Michele Perni, Michele Vendruscolo , et al. · 2020

Caenorhabditis elegans is a valuable model organism in biomedical research that has led to major discoveries in the fields of neurodegeneration, cancer and aging. Because movement phenotypes are commonly used and represent strong indicator…

Demo data for the publication "Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform" Open

Mandy Koopman, Peter Sutton, Renée I. Seinstra, Michele Perni, Michele Vendruscolo , et al. · 2019

Thus dataset is a demo data for the code found at https://github.com/impact27/WF_NTP (DOI: 10.5281/zenodo.3630199). It represents worms moving on a Petri dish, which can be tracked and analysed with the code

Saved by the Matrix: UPR Independent Survival under ER Stress Open

Mandy Koopman, Claudio Hetz, Ellen A. A. Nollen · 2019

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery Open

Michele Perni, Pavan K. Challa, Julius B. Kirkegaard, Ryan Limbocker, Mandy Koopman , et al. · 2018

Cellular Regulation of Amyloid Formation in Aging and Disease Open

Esther Stroo, Mandy Koopman, Ellen A. A. Nollen, Alejandro Mata‐Cabana · 2017

As the population is aging, the incidence of age-related neurodegenerative diseases, such as Alzheimer and Parkinson disease, is growing. The pathology of neurodegenerative diseases is characterized by the presence of protein aggregates of…

Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase Open

Helen Michels, Renée I. Seinstra, Joost C.M. Uitdehaag, Mandy Koopman, Martijn van Faassen , et al. · 2016

The enzyme TDO (tryptophan 2,3-dioxygenase; TDO-2 in Caenorhabditis elegans ) is a potential therapeutic target to cancer but is also thought to regulate proteotoxic events seen in the progression of neurodegenerative diseases. To better u…

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans Open

Mandy Koopman, Helen Michels, Beverley M. Dancy, Rashmi Kamble, Laurent Mouchiroud , et al. · 2016

Exploring Photogrammetric Point Clouds Open

Mandy Koopman, P. Soffers, M. Kastelijns, A.M. Ntarladima, J. Ten Kate , et al. · 2015

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