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View article: A novel methodological approach to understanding the cortical and subcortical effects of aerobic exercise in Parkinson’s disease
A novel methodological approach to understanding the cortical and subcortical effects of aerobic exercise in Parkinson’s disease Open
Introduction Aerobic exercise mitigates symptoms of Parkinson’s disease (PD) and may slow disease progression; however, the neural mechanisms underlying these improvements are not well understood. In this study, we discuss the methodology …
View article: Characterizing Stair Ambulation Kinetics and the Effects of Dual Tasking in Parkinson’s Disease
Characterizing Stair Ambulation Kinetics and the Effects of Dual Tasking in Parkinson’s Disease Open
Background: Stair ambulation is a complex motor task that presents a substantial fall risk for people with Parkinson’s disease (PwPD) who often have postural instability and gait difficulty (PIGD) and experience unpredictable freezing of g…
View article: An Experimental Approach for Investigating Freezing of Gait in Parkinson’s Disease Using Virtual Reality and Neural Sensing: A Pilot Study
An Experimental Approach for Investigating Freezing of Gait in Parkinson’s Disease Using Virtual Reality and Neural Sensing: A Pilot Study Open
Freezing of gait (FOG) is a disabling symptom associated with Parkinson’s disease (PD). Its understanding and effective treatment is compromised due to the difficulty in reliably triggering FOG in clinical and laboratory environments. The …
View article: Validation of the Comprehensive Augmented Reality Testing Platform to Quantify Parkinson’s Disease Fine Motor Performance
Validation of the Comprehensive Augmented Reality Testing Platform to Quantify Parkinson’s Disease Fine Motor Performance Open
Background/Objectives: Technological approaches for the objective, quantitative assessment of motor functions have the potential to improve the medical management of people with Parkinson’s disease (PwPD), offering more precise, data-drive…
View article: Gait patterns during overground and virtual omnidirectional treadmill walking
Gait patterns during overground and virtual omnidirectional treadmill walking Open
Background Omnidirectional treadmills (ODTs) offer a promising solution to the virtual reality (VR) locomotion problem, which describes the mismatch between visual and somatosensory information and contributes to VR sickness. However, litt…
View article: Older adults are impaired in the release of grip force during a force tracking task
Older adults are impaired in the release of grip force during a force tracking task Open
Age-related changes in force generation have been implicated in declines in older adult manual dexterity. While force generation is a critical aspect of the successful manipulation of objects, the controlled release of force represents the…
View article: Older adults exhibit declines in instrumental activities of daily living during a virtual grocery shopping task
Older adults exhibit declines in instrumental activities of daily living during a virtual grocery shopping task Open
Introduction: The successful performance of instrumental activities of daily living (IADLs) is critical in maintaining independence for older adults. Traditional IADL questionnaires and performance-based assessments are time consuming, pot…
View article: The Microsoft HoloLens 2 Provides Accurate Biomechanical Measures of Performance During Military-Relevant Activities in Healthy Adults
The Microsoft HoloLens 2 Provides Accurate Biomechanical Measures of Performance During Military-Relevant Activities in Healthy Adults Open
Introduction Augmented reality systems, like the HoloLens 2 (HL2), have the potential to provide accurate assessments of mild traumatic brain injury (mTBI) symptoms in military personnel by simulating complex military scenarios while objec…
View article: Development of the Troop Readiness Evaluation With Augmented Reality Return-to-Duty (Troop READY) Platform to Aid in the Detection and Treatment of Military Mild Traumatic Brain Injury
Development of the Troop Readiness Evaluation With Augmented Reality Return-to-Duty (Troop READY) Platform to Aid in the Detection and Treatment of Military Mild Traumatic Brain Injury Open
Introduction Mild traumatic brain injury (mTBI) is prevalent in service members (SMs); however, there is a lack of consensus on the appropriate approach to return to duty (RTD). Head-mounted augmented reality technology, such as the HoloLe…
View article: The Parkinson’s disease waiting room of the future: measurements, not magazines
The Parkinson’s disease waiting room of the future: measurements, not magazines Open
Utilizing technology to precisely quantify Parkinson’s disease motor symptoms has evolved over the past 50 years from single point in time assessments using traditional biomechanical approaches to continuous monitoring of performance with …
View article: Increased Comfortable Gait Speed Is Associated With Improved Gait Biomechanics in Persons With Chronic Stroke Completing an 8-Week Forced-Rate Aerobic Cycling Intervention
Increased Comfortable Gait Speed Is Associated With Improved Gait Biomechanics in Persons With Chronic Stroke Completing an 8-Week Forced-Rate Aerobic Cycling Intervention Open
Task-specific gait training is recommended to improve locomotor function after stroke. Our objective was to determine the effects of a forced-rate aerobic exercise intervention on gait velocity and biomechanics in the absence of task-speci…
View article: Bradykinesia and Its Progression Are Related to Interhemispheric Beta Coherence
Bradykinesia and Its Progression Are Related to Interhemispheric Beta Coherence Open
Objective Bradykinesia is the major cardinal motor sign of Parkinson disease (PD), but its neural underpinnings are unclear. The goal of this study was to examine whether changes in bradykinesia following long‐term subthalamic nucleus (STN…
View article: Community‐based high‐intensity cycling improves disease symptoms in individuals with Parkinson's disease: A six‐month pragmatic observational study
Community‐based high‐intensity cycling improves disease symptoms in individuals with Parkinson's disease: A six‐month pragmatic observational study Open
Participation in supervised, laboratory-based aerobic exercise protocols holds promise in slowing the progression of Parkinson's disease (PD). Gaps remain regarding exercise adherence and effectiveness of laboratory protocols translated to…
View article: Long-Term Subcortical Electrophysiological Recordings Link Heightened Interhemispheric Subthalamic Beta Synchrony to Progression of Bradykinesia in Parkinson’s Disease
Long-Term Subcortical Electrophysiological Recordings Link Heightened Interhemispheric Subthalamic Beta Synchrony to Progression of Bradykinesia in Parkinson’s Disease Open
Bradykinesia is the major cardinal motor sign of Parkinson’s disease (PD), but its neural underpinnings are unclear. Although impairment in PD has been linked to heightened synchrony within the beta band (13-30 Hz) in the subthalamic nucle…
View article: The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living
The Immersive Cleveland Clinic Virtual Reality Shopping Platform for the Assessment of Instrumental Activities of Daily Living Open
A decline in the performance of instrumental activities of daily living (IADLs) has been proposed as a prodromal marker of neurological disease. Existing clinical and performance-based IADL assessments are not feasible for integration into…
View article: The Microsoft HoloLens 2 Provides Accurate Measures of Gait, Turning, and Functional Mobility in Healthy Adults
The Microsoft HoloLens 2 Provides Accurate Measures of Gait, Turning, and Functional Mobility in Healthy Adults Open
Augmented-reality (AR) headsets, such as the Microsoft HoloLens 2 (HL2), have the potential to be the next generation of wearable technology as they provide interactive digital stimuli in the context of ecologically-valid daily activities …
View article: Lack of progression of beta dynamics after long‐term subthalamic neurostimulation
Lack of progression of beta dynamics after long‐term subthalamic neurostimulation Open
Objective To investigate the progression of neural and motor features of Parkinson's disease in a longitudinal study, after washout of medication and bilateral subthalamic nucleus deep brain stimulation (STN DBS). Methods Participants with…
View article: Use of a Smartphone to Gather Parkinson’s Disease Neurological Vital Signs during the COVID-19 Pandemic
Use of a Smartphone to Gather Parkinson’s Disease Neurological Vital Signs during the COVID-19 Pandemic Open
Introduction. To overcome travel restrictions during the COVID-19 pandemic, consumer-based technology was rapidly deployed to the smartphones of individuals with Parkinson’s disease (PD) participating in a 12-month exercise trial. The aim …
View article: Quantification of Dual-task Performance in Healthy Young Adults Suitable for Military Use
Quantification of Dual-task Performance in Healthy Young Adults Suitable for Military Use Open
Introduction Dual-task performance, in which an individual performs two tasks simultaneously, is compromised following mild traumatic brain injury (mTBI). Proficient dual-task performance is essential in a military setting for both militar…
View article: Development and Validation of a Mobile Application to Detect Visual Dysfunction Following Mild Traumatic Brain Injury
Development and Validation of a Mobile Application to Detect Visual Dysfunction Following Mild Traumatic Brain Injury Open
Introduction Following mild traumatic brain injury, visual dysfunction is a common occurrence, yet the condition often goes undiagnosed. A mobile application was developed to measure aspects of visual acuity and oculomotor function. The ai…
View article: A Validated Measure of Rigidity in Parkinson’s Disease Using Alternating Finger Tapping on an Engineered Keyboard
A Validated Measure of Rigidity in Parkinson’s Disease Using Alternating Finger Tapping on an Engineered Keyboard Open
Introduction Reliable and accurate measures of rigidity have remained elusive in remote assessments of Parkinson’s disease (PD). This has severely limited the utility of telemedicine in the care and treatment of people with PD. It has also…
View article: Military-Specific Normative Data for Cognitive and Motor Single- and Dual-Task Assessments for Use in Mild Traumatic Brain Injury Assessment
Military-Specific Normative Data for Cognitive and Motor Single- and Dual-Task Assessments for Use in Mild Traumatic Brain Injury Assessment Open
Introduction Military personnel and civilian athletes are both at risk for mild traumatic brain injury. However, these groups are unique in their training and typical daily activities. A fundamental gap in the evaluation of military person…
View article: Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease
Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease Open
A fundamental challenge in the clinical care of Parkinson disease (PD) is the current dependence on subjective evaluations of tremor and bradykinesia. New technologies offer the ability to evaluate motor deficits using purely objective mea…
View article: A Mobile Device Dual-Task Paradigm for the Assessment of mTBI
A Mobile Device Dual-Task Paradigm for the Assessment of mTBI Open
Research Objective Dual-task performance, in which individuals complete two or more activities simultaneously, is impaired following mild traumatic brain injury. The aim of this project was to develop a dual-task paradigm that may be condu…
View article: Normative Performance on the Balance Error Scoring System by Youth, High School, and Collegiate Athletes
Normative Performance on the Balance Error Scoring System by Youth, High School, and Collegiate Athletes Open
Context: Annually, more than 1 million youth athletes in the United States receive or are suspected of receiving a concussion. The Balance Error Scoring System (BESS) is the most commonly used clinical balance evaluation designed to provid…