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View article: SLC45A4 is a pain gene encoding a neuronal polyamine transporter
SLC45A4 is a pain gene encoding a neuronal polyamine transporter Open
View article: Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis
Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis Open
Autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the development of disease-causing B cells and autoantibodies. Convention suggests that such autoreactivities are generated…
View article: Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis
Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis Open
Autoimmunity affects 10% of the population. Within this umbrella, autoantibody-mediated diseases targeting one autoantigen provide a unique opportunity to comprehensively understand the developmental pathway of disease-causing B cells and …
View article: Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter.
Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter. Open
Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders including stroke, epilepsy and neurodegeneration and can regulate ne…
View article: A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity
A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity Open
Neuronal hyperexcitability is a key driver of persistent pain states, including neuropathic pain. Leucine-rich, glioma inactivated 1 (LGI1) is a secreted protein known to regulate excitability within the nervous system and is the target of…
View article: A role for LGI1 in regulating pain sensitivity
A role for LGI1 in regulating pain sensitivity Open
Chronic pain represents a major unmet clinical need. Neuropathic pain, that is pain arising due to damage or disease of the somatosensory nervous system, represents a sizeable proportion of chronic pain cases, affecting around 8% of the ge…
View article: 007 Immunotherapy responsive neuropathic pain associated with LGI1 and CASPR2 antibodies
007 Immunotherapy responsive neuropathic pain associated with LGI1 and CASPR2 antibodies Open
Objective We evaluated pain in leucine-rich glioma inactivated1(LGI1) and contactin-associated protein2(CASPR2)-antibody positive(Ab+) patients, to evaluate clinical associations and pathophysiology of treatable pain syndromes. Methods 108…
View article: Sodium-Calcium Exchanger-3 Regulates Pain ‘Wind-Up’: From Human Psychophysics to Spinal Mechanisms
Sodium-Calcium Exchanger-3 Regulates Pain ‘Wind-Up’: From Human Psychophysics to Spinal Mechanisms Open
View article: Issue Information
Issue Information Open
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View article: Evaluation of recombinant monoclonal antibody SVmab1 binding to NaV1.7 target sequences and block of human NaV1.7 currents
Evaluation of recombinant monoclonal antibody SVmab1 binding to NaV1.7 target sequences and block of human NaV1.7 currents Open
Identification of small and large molecule pain therapeutics that target the genetically validated voltage-gated sodium channel NaV1.7 is a challenging endeavor under vigorous pursuit. The monoclonal antibody SVmab1 was recently published …