Maneesh Jain
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View article: Targeting cancer-associated fibroblast-driven LIF/LIFR axis improves the therapeutic efficacy of gemcitabine and nab-paclitaxel in pancreatic cancer
Targeting cancer-associated fibroblast-driven LIF/LIFR axis improves the therapeutic efficacy of gemcitabine and nab-paclitaxel in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is inherently therapy resistant due to cancer cell-stroma crosstalk across several signaling pathways. Among these, the LIF/LIFR axis has been implicated in cancer cell and cancer-associated fibrobla…
View article: Brightly Visualizing Pancreatic Cancer Margins in Orthotopic Mouse Models with an Anti-CA19-9 Antibody Conjugated to a Near-Infrared Fluorophore
Brightly Visualizing Pancreatic Cancer Margins in Orthotopic Mouse Models with an Anti-CA19-9 Antibody Conjugated to a Near-Infrared Fluorophore Open
Background/Purpose: The only potentially curative procedure for pancreatic cancer is R0 resection, which is difficult to achieve due to poorly defined tumor margins. In the present study, we used an anti-CA19-9 antibody conjugated to a nea…
View article: Mucin4 (MUC4) Antibody Labeled with an NIR Dye Brightly Targets Pancreatic Cancer Liver Metastases and Peritoneal Carcinomatosis
Mucin4 (MUC4) Antibody Labeled with an NIR Dye Brightly Targets Pancreatic Cancer Liver Metastases and Peritoneal Carcinomatosis Open
Background/Objectives: Pancreatic cancer is the fourth leading cause of deaths related to cancer. It is a highly aggressive malignancy and often metastasizes quickly to other parts of the body and organs. The most effective cure is surgica…
View article: Molecular subtyping of hypertensive disorders of pregnancy
Molecular subtyping of hypertensive disorders of pregnancy Open
View article: Targeting Human Pancreatic Cancer with a Fluorophore-Conjugated Mucin 4 (MUC4) Antibody: Initial Characterization in Orthotopic Cell Line Mouse Models
Targeting Human Pancreatic Cancer with a Fluorophore-Conjugated Mucin 4 (MUC4) Antibody: Initial Characterization in Orthotopic Cell Line Mouse Models Open
Background/Objectives: Pancreatic cancer is the third leading cause of death related to cancer. The only possible cure presently is complete surgical resection; however, this is limited by difficulty in clearly defining tumor margins. Enha…
View article: A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone
A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone Open
View article: A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone
A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone Open
A blood test that enables surveillance for early-stage pancreatic ductal adenocarcinoma (PDAC) is an urgent need. Independent laboratories have reported PDAC biomarkers that could improve biomarker performance over CA19-9 alone, but the pe…
View article: Diffuse intrinsic pontine glioma (DIPG): A review of current and emerging treatment strategies
Diffuse intrinsic pontine glioma (DIPG): A review of current and emerging treatment strategies Open
View article: Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma
Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real…
View article: Dynamic phenotypic switching and group behavior help non-small cell lung cancer cells evade chemotherapy
Dynamic phenotypic switching and group behavior help non-small cell lung cancer cells evade chemotherapy Open
Drug resistance, a major challenge in cancer therapy, is typically attributed to mutations and genetic heterogeneity. On the other hand, emerging evidence suggests that dynamic cellular interactions and group behavior also contribute to dr…
View article: A Rigorous Multi-Laboratory Study of Known Pdac Biomarkers Identifies Increased Sensitivity and Specificity Over Ca19-9 Alone
A Rigorous Multi-Laboratory Study of Known Pdac Biomarkers Identifies Increased Sensitivity and Specificity Over Ca19-9 Alone Open
View article: 1181 Maternal and fetal tissue specific response to phthalate exposure in the third trimester
1181 Maternal and fetal tissue specific response to phthalate exposure in the third trimester Open
View article: Biological, diagnostic and therapeutic implications of exosomes in glioma
Biological, diagnostic and therapeutic implications of exosomes in glioma Open
View article: Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer Open
Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells correlated with increased expression of integrin β4 (ITGB4), a co…
View article: 2127P Long-term yoga reduces the side effects of systemic therapies and improves arm symptoms in the breast cancer patients
2127P Long-term yoga reduces the side effects of systemic therapies and improves arm symptoms in the breast cancer patients Open
View article: Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies
Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies Open
View article: <scp>GPCRs</scp> and fibroblast heterogeneity in fibroblast‐associated diseases
<span>GPCRs</span> and fibroblast heterogeneity in fibroblast‐associated diseases Open
G protein‐coupled receptors (GPCRs) are the largest and most diverse class of signaling receptors. GPCRs regulate many functions in the human body and have earned the title of “most targeted receptors”. About one‐third of the commercially …
View article: Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma Open
View article: Tumour extracellular vesicles and particles induce liver metabolic dysfunction
Tumour extracellular vesicles and particles induce liver metabolic dysfunction Open
View article: Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer, as it commonly metastasizes to the liver resulting in an overall poor prognosis. However, the molecular mechanism involved in liver metastasis remains poorl…
View article: Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Figure from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Supplementary Table from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
View article: Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion
Data from MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer, as it commonly metastasizes to the liver resulting in an overall poor prognosis. However, the molecular mechanism involved in liver metastasis remains poorl…
View article: Mucins as Potential Biomarkers for Early Detection of Cancer
Mucins as Potential Biomarkers for Early Detection of Cancer Open
Early detection significantly correlates with improved survival in cancer patients. So far, a limited number of biomarkers have been validated to diagnose cancers at an early stage. Considering the leading cancer types that contribute to m…
View article: MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma
MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma Open
MUC16/CA125 is one of the few oldest cancer biomarkers still used in current clinical practice. As mesothelium is an abundant source of MUC16 and a major contributor to stromal heterogeneity in PDAC, we investigated the regulation of MUC16…
View article: Scion/Rootstock Interaction Studies for Quality Traits in Mango (Mangifera indica L.) Varieties
Scion/Rootstock Interaction Studies for Quality Traits in Mango (Mangifera indica L.) Varieties Open
To explore the quality rootstocks which impart better quality fruits in mango varieties, we studied the interactive effect of the scion and rootstock using five mango varieties (Mallika, Amrapali, Dashehari, Pusa Arunima, and Pusa Surya) g…
View article: Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis
Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis Open
View article: MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis
MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis Open