Manesh Kumar Panner Selvam
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View article: Plasma circulating extracellular vesicles reveal dysregulation of synaptic signaling in SHIV-infected rhesus macaque
Plasma circulating extracellular vesicles reveal dysregulation of synaptic signaling in SHIV-infected rhesus macaque Open
View article: Comparative Proteomics of Seminal Exosomes Reveals Size-Exclusion Chromatography Outperforms Ultracentrifugation
Comparative Proteomics of Seminal Exosomes Reveals Size-Exclusion Chromatography Outperforms Ultracentrifugation Open
Background: Extracellular vesicles, particularly exosomes, play a crucial role in cell–cell communication and as carriers of biomarkers. However, their use in clinical settings is limited due to a lack of standardized isolation and charact…
View article: Injectable Antifibrotic Drug-Loaded Hydrogels Reduce Fibrosis and Restore Myogenesis by Targeting Mitochondria and Cell Mechanics
Injectable Antifibrotic Drug-Loaded Hydrogels Reduce Fibrosis and Restore Myogenesis by Targeting Mitochondria and Cell Mechanics Open
View article: Mitochondrial dysfunction signatures in idiopathic primary male infertility: a validated proteomics-based diagnostic approach
Mitochondrial dysfunction signatures in idiopathic primary male infertility: a validated proteomics-based diagnostic approach Open
Research question Male infertility accounts for almost half of all infertility cases worldwide, with idiopathic male infertility accounting for up to 30% of the cases. Sperm proteomics has revealed critical molecular pathway changes in men…
View article: Untargeted Metabolomic Profiling of Extracellular Vesicles Isolated from Human Seminal Plasma
Untargeted Metabolomic Profiling of Extracellular Vesicles Isolated from Human Seminal Plasma Open
Seminal extracellular vesicles (SemEVs) are repositories of biomolecules, including metabolites involved in the regulation of sperm function. The correlation between the metabolite profile of SemEVs and semen parameters, along with their r…
View article: Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches
Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches Open
Infertility is a prevalent global issue affecting approximately 17.5% of adults, with sole male factor contributing to 20–30% of cases. Oxidative stress (OS) is a critical factor in male infertility, disrupting the balance between reactive…
View article: Current Updates on Involvement of Artificial Intelligence and Machine Learning in Semen Analysis
Current Updates on Involvement of Artificial Intelligence and Machine Learning in Semen Analysis Open
Background and Objectives: Infertility rates and the number of couples undergoing reproductive care have both increased substantially during the last few decades. Semen analysis is a crucial step in both the diagnosis and the treatment of …
View article: Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma
Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma Open
Oxidative stress is increasingly implicated in male secondary infertility, where the seminal plasma altered proteome composition plays a critical role. This study aims to explore proteomic changes in the seminal plasma of fertile individua…
View article: Fibrinogen in mice cerebral microvessels induces blood–brain barrier dysregulation with aging via a dynamin-related protein 1–dependent pathway
Fibrinogen in mice cerebral microvessels induces blood–brain barrier dysregulation with aging via a dynamin-related protein 1–dependent pathway Open
We previously reported evidence that oxidative stress during aging leads to adverse protein profile changes of brain cortical microvessels (MVs: end arterioles, capillaries, and venules) that affect mRNA/protein stability, basement membran…
View article: Clomiphene Citrate in the Management of Infertility in Oligospermic Obese Men with Hypogonadism: Retrospective Pilot Study
Clomiphene Citrate in the Management of Infertility in Oligospermic Obese Men with Hypogonadism: Retrospective Pilot Study Open
Background and Objectives: Obesity is a significant risk factor for hypogonadism and infertility that is further associated with reduced semen quality. The aim of this study is to evaluate the effect of clomiphene citrate (CC), prescribed …
View article: A Scientometric Evaluation of COVID-19 and Male Reproductive Research
A Scientometric Evaluation of COVID-19 and Male Reproductive Research Open
The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by b…
View article: Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance
Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance Open
View article: (165) Role of Penile Veno-occlusive Dysfunction in Peyronie’s Disease Patients with Erectile Dysfunction
(165) Role of Penile Veno-occlusive Dysfunction in Peyronie’s Disease Patients with Erectile Dysfunction Open
Introduction The incidence of Peyronie's disease (PD) is 4% in the U.S. male population. Many PD patients also suffer from erectile dysfunction (ED). The etiology of ED incidence in PD men is not known, although veno-occlusive dysfunction …
View article: Association between Seminal Oxidation-Reduction Potential and Sperm DNA Fragmentation—A Meta-Analysis
Association between Seminal Oxidation-Reduction Potential and Sperm DNA Fragmentation—A Meta-Analysis Open
Seminal oxidative stress and sperm DNA damage are potential etiologies of male factor infertility. The present study aims to evaluate the relationship between oxidation-reduction potential (ORP), a measure of oxidative stress, and sperm DN…
View article: Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials
Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials Open
Background and Objectives: Male hypogonadism is a clinical disorder characterized by reduced serum testosterone in men. Although treatment using herbal medicines, including Eurycoma longifolia, has been investigated, the benefits remain un…
View article: Recent Publication Trends in Radiotherapy and Male Infertility over Two Decades: A Scientometric Analysis
Recent Publication Trends in Radiotherapy and Male Infertility over Two Decades: A Scientometric Analysis Open
Radiotherapy, a popular cancer management procedure, negatively impacts reproductive health particularly by reducing the fertility potential. The purpose of this study was to analyze the research trend in radiotherapy associated with male …
View article: Role of endocrine disruptors in male infertility and impact of COVID-19 on male reproduction
Role of endocrine disruptors in male infertility and impact of COVID-19 on male reproduction Open
View article: Telomere Signaling and Maintenance Pathways in Spermatozoa of Infertile Men Treated With Antioxidants: An in silico Approach Using Bioinformatic Analysis
Telomere Signaling and Maintenance Pathways in Spermatozoa of Infertile Men Treated With Antioxidants: An in silico Approach Using Bioinformatic Analysis Open
Telomere shortening is considered as a marker of cellular senescence and it is regulated by various signaling pathways. Sperm telomere appears to play important role in its longevity and function. Antioxidant intake has been known to preve…
View article: Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training
Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training Open
Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially spe…
View article: Standardized Laboratory Procedures, Quality Control and Quality Assurance Are Key Requirements for Accurate Semen Analysis in the Evaluation of Infertile Male
Standardized Laboratory Procedures, Quality Control and Quality Assurance Are Key Requirements for Accurate Semen Analysis in the Evaluation of Infertile Male Open
Semen analysis is a basic test for evaluating male fertility potential, as it plays an essential role in driving the future management and treatment of infertility in couples. Manual semen analysis includes the evaluation of both macroscop…
View article: Functional and Taxonomic Dysbiosis of the Gut, Urine, and Semen Microbiomes in Male Infertility
Functional and Taxonomic Dysbiosis of the Gut, Urine, and Semen Microbiomes in Male Infertility Open
We explored the resident populations of bacteria living in the gut, semen, and urine of infertile and fertile men. We found several important bacterial and metabolic pathway differences with the potential to aid in diagnosing and treating …
View article: An online educational model in andrology for student training in the art of scientific writing in the COVID‐19 pandemic
An online educational model in andrology for student training in the art of scientific writing in the COVID‐19 pandemic Open
In 2020, the COVID-19 pandemic led to the suspension of the annual Summer Internship at the American Center for Reproductive Medicine (ACRM). To transit it into an online format, an inaugural 6-week 2020 ACRM Online Mentorship Program was …
View article: A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility
A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility Open
This study is the largest online survey performed to date on this topic and demonstrates 1) a worldwide understanding of the importance of this therapeutic option, and 2) a widely prevalent use of antioxidants to treat male infertility. Fi…
View article: Best Practice Guidelines for Andrology Laboratory Services during COVID-19 Crisis: Cleveland Clinic's Experience
Best Practice Guidelines for Andrology Laboratory Services during COVID-19 Crisis: Cleveland Clinic's Experience Open
View article: Validation of LensHooke® X1 PRO and Computer-Assisted Semen Analyzer Compared with Laboratory-Based Manual Semen Analysis
Validation of LensHooke® X1 PRO and Computer-Assisted Semen Analyzer Compared with Laboratory-Based Manual Semen Analysis Open
Both automated semen analyzers demonstrated a high level of concordance and their performance was comparable with MSA analysis. Furthermore, high-levels of inter-and intra-rater reliability for semen analysis indicate that the new X1 PRO c…
View article: Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence
Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence Open
It is widely accepted that oxidative stress plays an important role in the pathophysiology of male infertility and that antioxidants could have a significant role in the treatment of male infertility. The main objectives of this study are:…
View article: Highly Cited Articles in the Field of Male Infertility and Antioxidants: A Scientometric Analysis
Highly Cited Articles in the Field of Male Infertility and Antioxidants: A Scientometric Analysis Open
The most influential publications on antioxidants and male infertility were identified for the first time in the literature. This will serve as a reliable source of information for researchers and clinicians alike.
View article: A scientometric analysis of research publications on male infertility and assisted reproductive technology
A scientometric analysis of research publications on male infertility and assisted reproductive technology Open
Assisted reproductive technologies (ART) are considered as one of the primary management options to address severe male factor infertility. The purpose of this study was to identify the research trends in the field of male infertility and …
View article: Dysregulation of Key Proteins Associated with Sperm Motility and Fertility Potential in Cancer Patients
Dysregulation of Key Proteins Associated with Sperm Motility and Fertility Potential in Cancer Patients Open
Cancer has adverse effects on male reproductive health. Conventional semen analysis does not explain the molecular changes in the spermatozoa of cancer patients. Currently, proteomics is being widely used to identify the fertility-associat…
View article: INSIGHTS IN THE MECHANISMS OF DEFECTIVE SPERM MATURATION IN INFERTILE MEN USING A COMPARATIVE PROTEOMICS APPROACH
INSIGHTS IN THE MECHANISMS OF DEFECTIVE SPERM MATURATION IN INFERTILE MEN USING A COMPARATIVE PROTEOMICS APPROACH Open