Manfred Beier
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View article: Supplementary Materials and Methods, Tables 1-4, Figures 1-5 from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells
Supplementary Materials and Methods, Tables 1-4, Figures 1-5 from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells Open
Supplementary Materials and Methods, Tables 1-4, Figures 1-5 from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells
View article: Data from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells
Data from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells Open
Platinum plays a central role in the therapy of ovarian cancer, and the emergence of platinum resistance is a major obstacle for clinical management of the disease. We treated A2780 ovarian cancer cells by weekly cycles of cisplatin over a…
View article: Data from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells
Data from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells Open
Platinum plays a central role in the therapy of ovarian cancer, and the emergence of platinum resistance is a major obstacle for clinical management of the disease. We treated A2780 ovarian cancer cells by weekly cycles of cisplatin over a…
View article: Supplementary Materials and Methods, Tables 1-4, Figures 1-5 from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells
Supplementary Materials and Methods, Tables 1-4, Figures 1-5 from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells Open
Supplementary Materials and Methods, Tables 1-4, Figures 1-5 from Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells
View article: Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin
Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin Open
In order to get a better insight into the timing of WT1 mutant Wilms tumor development, we compared the gene expression profiles of nine established WT1 mutant Wilms tumor cell lines with published data from different kidney cell types dur…
View article: ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis
ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis Open
A disintegrin and metalloproteinase (ADAM) family proteins, acting as sheddases, are important factors in a number of pathologies, including cancer, and have been suggested as promising therapeutic targets. The study presented focuses on t…
View article: Gene expression studies of <i>WT1</i> mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early stem cell origin
Gene expression studies of <i>WT1</i> mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early stem cell origin Open
In order to get a better insight into the timing of WT1 mutant Wilms tumor development, we compared the gene expression profiles of nine established WT1 mutant Wilms tumor cell lines with published data from different kidney cell types dur…
View article: TFF1 in Aqueous Humor—A Potential New Biomarker for Retinoblastoma
TFF1 in Aqueous Humor—A Potential New Biomarker for Retinoblastoma Open
Retinoblastoma (RB) is the most common childhood eye cancer. The expression of trefoil factor family peptide 1 (TFF1), a small secreted peptide, has been correlated with more advanced RB stages and it might be a promising new candidate as …
View article: Genetic analysis of single disseminated tumor cells in the lymph nodes and bone marrow of patients with head and neck squamous cell carcinoma
Genetic analysis of single disseminated tumor cells in the lymph nodes and bone marrow of patients with head and neck squamous cell carcinoma Open
Considering the limited information on the biology and molecular characteristics of disseminated tumor cells (DTCs) in head and neck squamous cell carcinoma (HNSCC), we examined the genomic alterations in DTCs from HNSCCs and their potenti…
View article: Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations
Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations Open
Purpose: WT1 mutant Wilms tumors represent a distinct subgroup, frequently associated with CTNNB1 mutations. The genetic basis for the development of this subtype is currently not fully understood. Methods: Live WT1 mutant Wilms tumors wer…
View article: Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines Open
View article: Chemotherapy and terminal skeletal muscle differentiation in <i><scp>WT</scp>1‐</i>mutant Wilms tumors
Chemotherapy and terminal skeletal muscle differentiation in <i><span>WT</span>1‐</i>mutant Wilms tumors Open
Wilms tumors (WT) with WT 1 mutations do not respond well to preoperative chemotherapy by volume reduction, suggesting resistance to chemotherapy. The histologic pattern of this tumor subtype indicates an intrinsic mesenchymal differentiat…
View article: Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases
Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases Open
View article: Reduction of the tumorigenic potential of human retinoblastoma cell lines by<i>TFF1</i>overexpression involves p53/caspase signaling and miR-18a regulation
Reduction of the tumorigenic potential of human retinoblastoma cell lines by<i>TFF1</i>overexpression involves p53/caspase signaling and miR-18a regulation Open
Trefoil factor family (TFF) peptides have been shown to play a pivotal role in oncogenic transformation, tumorigenesis and metastasis by changing cell proliferation, apoptosis, migration and invasion behavior of various cancer cell lines. …
View article: MOESM1 of Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases
MOESM1 of Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases Open
Additional file 1: Figure S1. ACGH-Profiles of each sample. The log-2-ratio is displayed in the y-axis, the localization on the genome is displayed on the x-axis. Called gains are marked orange, called losses are marked blue.
View article: Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15
Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15 Open
We describe a stromal predominant Wilms tumor with focal anaplasia and a complex, tumor specific chromosome 11 aberration: a homozygous deletion of the entire WT1 gene within a heterozygous 11p13 deletion and an additional region of unipar…