Manfred Eggersdorfer
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View article: What Is a Vitamin? Towards a Contemporary Definition
What Is a Vitamin? Towards a Contemporary Definition Open
Background: The concept of vitamins has evolved over the past century from compounds preventing classical deficiency diseases to nutrients recognized for supporting long-term health. Despite their central role in science and public health,…
View article: GLP-1 Receptor Agonists – Good for Body Weight, Bad for Micronutrient Status?
GLP-1 Receptor Agonists – Good for Body Weight, Bad for Micronutrient Status? Open
Obesity is a global health issue with a prevalence predicted to affect 24% of the world's population by 2035. A high-caloric intake and a sedentary lifestyle are, along with other factors, the main causes of obesity. Since 2014, the pharma…
View article: Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial
Effects of vitamin D3, omega-3s, and a simple home exercise program on incident vertebral fractures: the DO-HEALTH randomized controlled trial Open
Vertebral fractures (VFs) are among the most common osteoporotic fractures. The effect of vitamin D3, omega-3s or a simple home exercise program (SHEP) on VFs is unclear. We examined whether vitamin D3, omega-3s, or SHEP, alone or in combi…
View article: Assessment of micronutrients – searching for the evidence
Assessment of micronutrients – searching for the evidence Open
View article: Defining a vitamin A5/X specific deficiency – vitamin A5/X as a critical dietary factor for mental health
Defining a vitamin A5/X specific deficiency – vitamin A5/X as a critical dietary factor for mental health Open
A healthy and balanced diet is an important factor to assure a good functioning of the central and peripheral nervous system. Retinoid X receptor (RXR)-mediated signaling was identified as an important mechanism of transmitting major diet-…
View article: Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial
Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial Open
Evidence on the effects of Vitamin D, omega-3s, and exercise on areal bone mineral density (aBMD) in healthy older adults is limited. We examined whether vitamin D3, omega-3s, or a simple home-based exercise program (SHEP), alone or in com…
View article: Vitamin E: Not only a single stereoisomer
Vitamin E: Not only a single stereoisomer Open
The recent publication by Azzi and colleagues puts forth the argument that only RRR-α-tocopherol should be considered as vitamin E from a physiological point of view. They base their argument primarily on the assertion that only this form …
View article: Oral supplementation of vitamin D is safe and can be an effective strategy to fill the nutritional gap
Oral supplementation of vitamin D is safe and can be an effective strategy to fill the nutritional gap Open
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View article: There is no evidence that vitamin D supplementation drives the progression of Alzheimer's disease
There is no evidence that vitamin D supplementation drives the progression of Alzheimer's disease Open
If there is anything the last few decades have taught us, it is that researchers must properly conduct studies on vitamin supplements before they can make health claims. In a recent paper by Lai et al. (2022), the authors state, "vitamin D…
View article: Letter to the editor: “Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-Analysis”
Letter to the editor: “Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-Analysis” Open
View article: 100 Years of Vitamin E: From Discovery to Commercialization
100 Years of Vitamin E: From Discovery to Commercialization Open
2022 marks the centenary of the discovery of vitamin E by Evans and Bishop, an important milestone in vitamin research. An enormous amount of scientific data related to the importance of its activity has been published on this micronutrien…
View article: Iron Deficiency and Incident Infections among Community-Dwelling Adults Age 70 Years and Older: Results from the DO-HEALTH Study
Iron Deficiency and Incident Infections among Community-Dwelling Adults Age 70 Years and Older: Results from the DO-HEALTH Study Open
View article: Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study
Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study Open
View article: Perspective: Role of Micronutrients and Omega-3 Long-Chain Polyunsaturated Fatty Acids for Immune Outcomes of Relevance to Infections in Older Adults—A Narrative Review and Call for Action
Perspective: Role of Micronutrients and Omega-3 Long-Chain Polyunsaturated Fatty Acids for Immune Outcomes of Relevance to Infections in Older Adults—A Narrative Review and Call for Action Open
The immune system is weakened by advancing age, often referred to as immunosenescence, increasing the vulnerability to, and frequently the severity of, infectious diseases in older people. This has become very apparent in the current coron…
View article: Micronutrients to Support Vaccine Immunogenicity and Efficacy
Micronutrients to Support Vaccine Immunogenicity and Efficacy Open
The world has entered the third year of the coronavirus disease 2019 (COVID-19) pandemic. Vaccination is the primary public health strategy to protect against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in …
View article: Prevalence and incidence of iron deficiency in European community-dwelling older adults: an observational analysis of the DO-HEALTH trial
Prevalence and incidence of iron deficiency in European community-dwelling older adults: an observational analysis of the DO-HEALTH trial Open
View article: The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights
The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights Open
Life expectancy as a measure of population health does not reflect years of healthy life. The average life expectancy in the Asia-Pacific region has more than doubled since 1900 and is now above 70 years. In the Asia-Pacific region, the pr…
View article: Chronic Vitamin E Deficiency in Rural Bangladeshi Women
Chronic Vitamin E Deficiency in Rural Bangladeshi Women Open
OBJECTIVES: Vitamin E deficiency (VED) appears to be common in rural areas of South Asia, with prevalence of ≥ 50% reported among women of reproductive age. Long term deficiency may impart neurological damage, but little information exists…
View article: Beyond Nutrient Deficiency—Opportunities to Improve Nutritional Status and Promote Health Modernizing DRIs and Supplementation Recommendations
Beyond Nutrient Deficiency—Opportunities to Improve Nutritional Status and Promote Health Modernizing DRIs and Supplementation Recommendations Open
The US Dietary Guidelines for Americans (DGA) provide dietary recommendations to meet nutrient needs, promote health, and prevent disease. Despite 40 years of DGA, the prevalence of under-consumed nutrients continues in the US and globally…
View article: Strengthening the immunity of the Swiss population with micronutrients: A narrative review and call for action
Strengthening the immunity of the Swiss population with micronutrients: A narrative review and call for action Open
View article: Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study
Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study Open
View article: Vitamin B6, Inflammation, and Cardiovascular Outcome in a Population-Based Cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) Study
Vitamin B6, Inflammation, and Cardiovascular Outcome in a Population-Based Cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) Study Open
Background: a large number of studies have linked vitamin B6 to inflammation and cardiovascular disease in the general population. However, it remains uncertain whether vitamin B6 is associated with cardiovascular outcome independent of in…
View article: Reply to “Overstated Claims of Efficacy and Safety. Comment On: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients 2020, 12, 1181”
Reply to “Overstated Claims of Efficacy and Safety. Comment On: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients 2020, 12, 1181” Open
We thank Vorland et al [...]
View article: Nutritional Status and Diet in Elderly with Low and High Socioeconomic Status
Nutritional Status and Diet in Elderly with Low and High Socioeconomic Status Open
Background Socioeconomic status (SES) patterned health disparities have been related to differences in dietary intake, especially in the elderly. Still, it is not known to what extent these differences culminate in vitamin deficiencies, as…
View article: Vitamin Status and Diet in Elderly with Low and High Socioeconomic Status: The Lifelines-MINUTHE Study
Vitamin Status and Diet in Elderly with Low and High Socioeconomic Status: The Lifelines-MINUTHE Study Open
Socioeconomic health inequalities are an important global public health problem. However, it is not well known to what extent socioeconomic inequalities culminate in impaired vitamin status and whether this is mediated by diet. We, therefo…
View article: Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition
Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition Open
Life expectancy is increasing and so is the prevalence of age-related non-communicable diseases (NCDs). Consequently, older people and patients present with multi-morbidities and more complex needs, putting significant pressure on healthca…
View article: Reply to “Comment on: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients 2020, 12, 1181”
Reply to “Comment on: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. Nutrients 2020, 12, 1181” Open
We thank Tsoupras and Zabetakis for their interest in our recent publication [...]
View article: Metabolic and functional interplay between gut microbiota and fat-soluble vitamins
Metabolic and functional interplay between gut microbiota and fat-soluble vitamins Open
Gut microbiota is a complex ecosystem seen as an extension of human genome. It represents a major metabolic interface of interaction with food components and xenobiotics in the gastrointestinal (GI) environment. In this context, the advent…
View article: Vitamin E Deficiency Is Associated with Reduced Handgrip Strength in Rural Nepalese Children
Vitamin E Deficiency Is Associated with Reduced Handgrip Strength in Rural Nepalese Children Open
View article: Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections
Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections Open
Public health practices including handwashing and vaccinations help reduce the spread and impact of infections. Nevertheless, the global burden of infection is high, and additional measures are necessary. Acute respiratory tract infections…