Manfred Herold
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View article: Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop
Reflecting on a decade of the international consensus on ANA patterns (ICAP): Accomplishments and challenges from the perspective of the 7th ICAP workshop Open
View article: Prediction of ineffectiveness of biological drugs using machine learning and explainable AI methods: data from the Austrian Biological Registry BioReg
Prediction of ineffectiveness of biological drugs using machine learning and explainable AI methods: data from the Austrian Biological Registry BioReg Open
View article: Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts
Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts Open
Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative, owing to the inevitable occurrence of drug resistance. There is increasing evidence that epithelial glucocorticoid …
View article: POS0641 MACHINE LEARNING AND EXPLAINABLE AI METHODS CAN HELP TO PREDICT THE INEFFECTIVENESS OF INDIVIDUAL BIOLOGICAL DISEASE MODIFYING ANTIRHEUMATIC DRUGS (bDMARDS) – DATA FROM THE AUSTRIAN BIOLOGICAL REGISTRY BIOREG
POS0641 MACHINE LEARNING AND EXPLAINABLE AI METHODS CAN HELP TO PREDICT THE INEFFECTIVENESS OF INDIVIDUAL BIOLOGICAL DISEASE MODIFYING ANTIRHEUMATIC DRUGS (bDMARDS) – DATA FROM THE AUSTRIAN BIOLOGICAL REGISTRY BIOREG Open
Background The continuous development of biological disease modifying antirheumatic drugs (bDMARDs) in recent years has significantly improved the treatment options for patients suffering from rheumatoid arthritis. Selecting the most effec…
View article: Detection of antinuclear antibodies: recommendations from EFLM, EASI and ICAP
Detection of antinuclear antibodies: recommendations from EFLM, EASI and ICAP Open
Objectives Antinuclear antibodies (ANA) are important for the diagnosis of various autoimmune diseases. ANA are usually detected by indirect immunofluorescence assay (IFA) using HEp-2 cells (HEp-2 IFA). There are many variables influencing…
View article: Rheuma nach COVID-19-Infektion oder Impfung
Rheuma nach COVID-19-Infektion oder Impfung Open
Zusammenfassung Sowohl nach COVID-Infektion als auch nach ein oder mehreren COVID-Impfungen können rheumatische Beschwerden beginnen. In beiden Fällen scheint der Mechanismus ähnlich zu sein und mit dem Coronavirus oder seinen spezifischen…
View article: Repository of intra- and inter-run variations of quantitative autoantibody assays: a European multicenter study
Repository of intra- and inter-run variations of quantitative autoantibody assays: a European multicenter study Open
Objectives No reference data are available on repositories to measure precision of autoantibody assays. The scope of this study was to document inter- and intra-run variations of quantitative autoantibody assays based on a real-world large…
View article: Commentary: Strong Association of the Myriad Discrete Speckled Nuclear Pattern With Anti-SS-A/Ro60 Antibodies: Consensus Experience of Four International Expert Centers
Commentary: Strong Association of the Myriad Discrete Speckled Nuclear Pattern With Anti-SS-A/Ro60 Antibodies: Consensus Experience of Four International Expert Centers Open
GENERAL COMMENTARY article Front. Immunol., 18 March 2022Sec. Cytokines and Soluble Mediators in Immunity Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.840960
View article: Correction to: The International Consensus on ANA Patterns (ICAP) in 2021—the 6th Workshop and Current Perspectives
Correction to: The International Consensus on ANA Patterns (ICAP) in 2021—the 6th Workshop and Current Perspectives Open
View article: Update on treatment strategies for vasculitis affecting the central nervous system
Update on treatment strategies for vasculitis affecting the central nervous system Open
Vasculitis affecting the nervous system is a rare disease that can not only present with nonspecific initial symptoms, but also run a severe course without accurate treatment. Although improvements have been achieved, diagnosis of vasculit…
View article: The impact of the COVID-19 pandemic on autoimmune diagnostics in Europe: A lesson to be learned
The impact of the COVID-19 pandemic on autoimmune diagnostics in Europe: A lesson to be learned Open
View article: The International Consensus on ANA Patterns (ICAP) in 2021—The 6th Workshop and Current Perspectives
The International Consensus on ANA Patterns (ICAP) in 2021—The 6th Workshop and Current Perspectives Open
The establishment of the International Consensus on ANA Patterns (ICAP) in 2014–2015 was welcomed by members of the medical community as a significant improvement in guiding harmonization of ANA test interpretation and reporting. In the su…
View article: How to report the antinuclear antibodies (anti-cell antibodies) test on HEp-2 cells: guidelines from the ICAP initiative
How to report the antinuclear antibodies (anti-cell antibodies) test on HEp-2 cells: guidelines from the ICAP initiative Open
View article: Delivery of blistered Medicines as an Important Factor in Medication Safety and Maintaining Patient Health in Times of Lockdown due to COVID-19
Delivery of blistered Medicines as an Important Factor in Medication Safety and Maintaining Patient Health in Times of Lockdown due to COVID-19 Open
The whole world is holding its breath and has fallen into a kind of paralysis of shock: the Corona pandemic is affecting the lives of every single person on Earth. Many have fallen ill, many have died, almost everyone is in lockdown. But e…
View article: Overcoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics
Overcoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics Open
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and reagents needed for diagnostic…
View article: Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey
Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey Open
View article: Quality and best practice in medical laboratories: specific requests for autoimmunity testing
Quality and best practice in medical laboratories: specific requests for autoimmunity testing Open
Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical device regulation (IVD-R). In addi…
View article: Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey. 
Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey. Open
Background The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes competent-level from …
View article: Current Laboratory and Clinical Practices in Reporting and Interpreting Anti-nuclear Antibody Indirect Immunofluorescence (ANA IIF) Patterns: Results of an International Survey
Current Laboratory and Clinical Practices in Reporting and Interpreting Anti-nuclear Antibody Indirect Immunofluorescence (ANA IIF) Patterns: Results of an International Survey Open
BackgroundThe International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes competent-levelfrom ex…
View article: Overcoming Limitations in the Availability of Swabs Systems Used for SARS-CoV-2 Laboratory Diagnostics
Overcoming Limitations in the Availability of Swabs Systems Used for SARS-CoV-2 Laboratory Diagnostics Open
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and reagents needed for diagnostic…
View article: Response to ‘Titre-specific positive predictive value of anti-nuclear antibody patterns' by Vulsteke et al
Response to ‘Titre-specific positive predictive value of anti-nuclear antibody patterns' by Vulsteke et al Open
View article: Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective
Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective Open
View article: AB0261 Ongoing good response with biologics. data from the austrian biorg registry
AB0261 Ongoing good response with biologics. data from the austrian biorg registry Open
View article: International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I
International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I Open
The indirect immunofluorescence assay (IFA) on HEp-2 cells is the reference method for autoantibody screening. The HEp-2 IFA pattern provides useful information on the possible autoantibodies in the sample. The International Consensus on A…
View article: ICAP – ein Versuch zur einheitlichen Beschreibung der Fluoreszenzmuster von antizellulären Antikörpern auf HEp-2-Zellen
ICAP – ein Versuch zur einheitlichen Beschreibung der Fluoreszenzmuster von antizellulären Antikörpern auf HEp-2-Zellen Open
Zusammenfassung Primäres Ziel von ICAP (internationaler Konsens für antinukleäre Antikörpermuster) ist es, einen Konsens zu finden zur Beschreibung der Fluoreszenzmuster, die mit indirekter Immunfluoreszenztechnik auf HEp-2-Zellen erkannt …
View article: An international survey on anti-neutrophil cytoplasmic antibodies (ANCA) testing in daily clinical practice
An international survey on anti-neutrophil cytoplasmic antibodies (ANCA) testing in daily clinical practice Open
Background: Detection of anti-neutrophil cytoplasmic antibodies (ANCA) is important for the diagnosis of the ANCA-associated vasculitides (AAV). For AAV, especially ANCA directed against myeloperoxidase (MPO) and proteinase 3 (PR3) are mos…
View article: Strontium Ranelate Might be a Therapeutic Option for Treatment of CRPS
Strontium Ranelate Might be a Therapeutic Option for Treatment of CRPS Open
The postmenopausal osteoporosis of a 66-year-old female with long lasting end stage complex regional pain syndrome on the right hand was treated with strontium ranelate 2 grams daily. After few weeks of treatment an impressive improvement …
View article: Erratum to: Validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology: current practice of bDMARD therapy in rheumatoid arthritis in Austria
Erratum to: Validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology: current practice of bDMARD therapy in rheumatoid arthritis in Austria Open
After publication of the original article [1], it came to the authors' attention that in the third paragraph of the 'Discussion' section, the value of DAS28 in NEW included patients is indicated wrongly, although correctly cited in Table 2…
View article: Validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology: current practice of bDMARD therapy in rheumatoid arthritis in Austria
Validity of data collected in BIOREG, the Austrian register for biological treatment in rheumatology: current practice of bDMARD therapy in rheumatoid arthritis in Austria Open
View article: Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015
Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015 Open
The second meeting for the International Consensus on Antinuclear antibody (ANA) Pattern (ICAP) was held on 22 September 2015, one day prior to the opening of the 12th Dresden Symposium on Autoantibodies in Dresden, Germany. The ultimate g…