Marc Schmid
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Relationships between adverse childhood experiences, oxidative stress, and development of mental disorders: A systematic review of animal and human studies Open
Adverse childhood experiences (ACE) are common risk factors for many psychiatric disorders. Their underlying biological mechanisms may involve oxidative stress (OS), which has deleterious effects on cells through its own actions and throug…
View article: Reducing Problematic Parenting Behaviors, Child Neglect, and Internalizing and Externalizing Problems in Multisystemic Therapy for Child Abuse and Neglect
Reducing Problematic Parenting Behaviors, Child Neglect, and Internalizing and Externalizing Problems in Multisystemic Therapy for Child Abuse and Neglect Open
Multisystemic Therapy for Child Abuse and Neglect (MST-CAN) has been shown to effectively reduce social worker-assessed child neglect and child problems. However, no research has examined the effects of MST-CAN on parenting behaviors or id…
Epigenetic signatures of different types of childhood maltreatment in a high-risk sample: a preregistered replication study Open
Childhood maltreatment (CM) has long-lasting effects on physical and mental health with CM type specific effects being reported. Epigenetic processes, like deoxyribonucleic acid methylation (DNAm), might mediate this link, and CM types mig…
Redox dysregulation, inflammation and mental health in adults with high risk of childhood maltreatment Open
Childhood maltreatment (CM) increases the risk of lifelong mental illness, but the underlying biochemical pathways remain unclear. Oxidative stress (OS), alongside inflammation, may contribute to this link. This study examined OS as a pote…
Psychological resilience and childhood maltreatment: The role of self-efficacy, personality functioning and social support in young adult residential care leavers Open
Personality functioning and self-efficacy are crucial for psychological resilience following childhood maltreatment. They represent important targets for preventive interventions in youth residential care and therapy programs for those who…
Differential effects of childhood maltreatment types and timing on psychopathology in formerly out-of-home placed young adults Open
Background Childhood maltreatment (CM) increases the risk for psychopathology and CM type, severity and timing are considered important modulating factors in this relationship. However, reported associations are heterogeneous and hardly co…
Differential effects of childhood maltreatment types and timing on psychopathology in formerly out-of-home placed young adults Open
Childhood maltreatment (CM) increases the risk of psychopathology. Besides CM types and severity, the timing of exposure is an important modulating factor in this association, as childhood and adolescence comprise sensitive developmental p…
Adverse Childhood Experiences, Quality of Life and the Mediating Roles of Self-Efficacy and Self-Directedness in Youth Residential Care Leavers Open
Purpose Young people in youth residential care report high rates of adverse childhood experiences (ACEs), e.g., abuse and neglect in their families. Various studies show ACEs to impair social participation and mental health, whereas less i…
Childhood trauma is linked to epigenetic age deceleration in young adults with previous youth residential care placements Open
Background: Early adversity increases the risk for mental and physical disorders as well as premature death. Epigenetic processes, and altered epigenetic aging in particular, might mediate these effects. While the literature that examined …
Child and family characteristics in multisystemic therapy for child abuse and neglect (MST‐CAN): Are there associations with treatment outcome? Open
Evidence‐based indication for targeted interventions is a central approach in the field of child welfare and psychotherapy. This study explored the characteristics of children and families referred to Multisystemic Therapy for Child Abuse …
Limited prosocial emotions (LPE) specifier in conduct disorder and offending behavior: findings from a 10-year prospective longitudinal study of juveniles in residential care Open
Background Since the introduction of the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5, a limited prosocial emotion (LPE) specifier has been added to the conduct disorder (CD) diagnosis in addition to the age of onset speci…
Childhood maltreatment and mental health problems in a 10-year follow-up study of adolescents in youth residential care: A latent transition analysis Open
Childhood maltreatment and mental health problems are common among young people placed out-of-home. However, evidence on the impact of maltreatment on the course of mental health problems in at-risk populations is sparse. The aim of this l…
View article: Interplay between stress, sleep, and BDNF in a high-risk sample of young adults
Interplay between stress, sleep, and BDNF in a high-risk sample of young adults Open
Children in institutional care have a high risk to experience childhood adversities (CAs), with consequences for physical and mental well-being. The long-term effects of CAs on the brain, including consequences for neuronal plasticity and …
Assessing the Gendered General Strain Theory Over Time in Individuals with a Residential Care History Open
The gendered general strain theory posits that differences in delinquency across gender are due to differences in coping with negative emotions. The present study tests its validity over a 10-year follow-up. We measured exposure to strain,…
Examining the relationship between resting heart rate and callous-unemotional traits in juvenile delinquency Open
Purpose: Both the resting heart rate (RHR) and the callous-unemotional (CU) traits have been associated with juvenile delinquency, however the effect of their interaction is not yet clear.Methods: Four hundred and twenty-three institutiona…
Childhood Trauma Is Linked to Epigenetic Age Deceleration in Young Adults with Previous Youth Residential Care Placements Open
Background. Early adversity increases the risk for mental and physical disorders as well as premature death. Epigenetic processes, and altered epigenetic aging in particular, might mediate these effects. While the literature that examined …
Adverse childhood experiences increase the risk for low perceived social participation and health-related quality of life in a large-scale population-based study in Germany Open
This study shows people exposed to ACEs to have a higher risk for lower perceived social participation and lower health-related QoL - an increased risk, however, is not a deterministic uninventable fortune. Reduction of chronic stress, fos…
View article: In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway
In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway Open
Introduction Several diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against enca…
Key insights from studies on the stability of personality disorders in different age groups Open
While for decades, temporal stability has been conceived as a defining feature of personality disorders (PDs), cumulative findings appear to question the stability of PDs and PD symptoms over time. However, stability itself is a complex no…
The stability of personality disorders and personality disorder criteria: A systematic review and meta-analysis Open
The aim of this systematic review and meta-analysis was to investigate the diagnostic, the dimensional mean-level, and rank-order stability of personality disorders (PDs) and PD criteria over time. EMBASE, PsycInfo, PubMed, and Web of Scie…
Association of Indicators of Stress, Sleep and Brain-Derived Neurotrophic Factor (BDNF) in a High-risk Sample of Young Adults with Previous Youth Residential Care Open
BackgroundChildren in institutional care have a high risk to experience childhood adversities (CAs), with consequences for physical and mental well-being. The long-term effects of CAs on the brain, including consequences for neuronal plast…
Gender-Specific Significance of Peer Abuse during Childhood and Adolescence on Physical and Mental Health in Adulthood—Results from a Cross-Sectional Study in a Sample of Hospital Patients Open
Peer abuse (PA) is a widespread and gender-sensitive form of Adverse Childhood Experiences (ACEs). However, research on its influence on physical and mental health in adulthood remains scarce. The aim of this study was to investigate gende…
The Relationship of Temperament and Character, Parental Stress, and Mental Health Problems with Attachment Disorders among Children Open
According to Cloninger’s model, personality is conceptualized in temperament and character traits contributing to a child’s psychosocial development. Additionally, parent–child interaction is important for the child’s socio-emotional devel…
Adverse and traumatic exposures, posttraumatic stress disorder, telomere length, and hair cortisol – Exploring associations in a high-risk sample of young adult residential care leavers Open
Our findings are in contrast with many, but not all, previous studies of associations between adversity and both TL and HCC. For instance, our findings are in line with other studies that find a state of hypocortisolism in PTSD. Better mea…