Mangesh T. Jaykar
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View article: Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis Open
Background Glucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood. Methods We u…
View article: Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis Open
Glucocorticoids regulate hematopoiesis, but how chronic elevation of endogenous glucocorticoid production affects hematopoietic stem cell (HSC) function and immune cell development remains incompletely understood. Using an adrenocortical c…
View article: Hypoxia signaling pathway: A central mediator in endocrine tumors
Hypoxia signaling pathway: A central mediator in endocrine tumors Open
Adequate oxygen levels are essential for the functioning and maintenance of biological processes in virtually every cell, albeit based on specific need. Thus, any change in oxygen pressure leads to modulated activation of the hypoxia pathw…