Manho Kim
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View article: Decellularized extracellular matrix scaffolds from Pleurotus ferulae mushrooms for sustainable production of steak-like cultured meat with authentic texture
Decellularized extracellular matrix scaffolds from Pleurotus ferulae mushrooms for sustainable production of steak-like cultured meat with authentic texture Open
Replicating the fibrous texture of steak-like meat remains a significant hurdle to the commercialization of cultured meat as a sustainable alternative to conventional livestock farming. Many existing scaffolds often lack the biocompatibili…
View article: Current clinical trends in developing strategies for dementia disorders and the role of Korean Red Ginseng
Current clinical trends in developing strategies for dementia disorders and the role of Korean Red Ginseng Open
Recently, the development of the FDA approved monoclonal antibodies (mAbs) targeting amyloid proteins, such as aducanumab, lecanemab, and donanemab, etc. Although these are in initial stage, developing mAbs is believed to proposed as next …
View article: A Practical Guide for Diagnostic Investigations and Special Considerations in Patients With Huntington’s Disease in Korea
A Practical Guide for Diagnostic Investigations and Special Considerations in Patients With Huntington’s Disease in Korea Open
This review provides a comprehensive framework for the diagnostic approach and management of Huntington’s disease (HD) tailored to the Korean population. Key topics include genetic counseling, predictive testing, and reproductive options l…
View article: Gold Kiwi-Derived Nanovesicles Mitigate Ultraviolet-Induced Photoaging and Enhance Osteogenic Differentiation in Bone Marrow Mesenchymal Stem Cells
Gold Kiwi-Derived Nanovesicles Mitigate Ultraviolet-Induced Photoaging and Enhance Osteogenic Differentiation in Bone Marrow Mesenchymal Stem Cells Open
Bone marrow mesenchymal stem cells (BM-MSCs) play a crucial role in bone formation through their ability to differentiate into osteoblasts. Aging, however, detrimentally affects the differentiation and proliferation capacities of BM-MSCs, …
View article: Effects of Artemisia asiatica ex on Akkermansia muciniphila dominance for modulation of Alzheimer’s disease in mice
Effects of Artemisia asiatica ex on Akkermansia muciniphila dominance for modulation of Alzheimer’s disease in mice Open
The gut microbiome influences neurological disorders through bidirectional communication between the gut and the brain, i.e., the gut-brain axis. Artemisia asiatica ex , an extract of Artemisia asiatica Nakai (Stillen®, DA-9601) has been r…
View article: Evidence-Based Review on Symptomatic Management of Huntington’s Disease
Evidence-Based Review on Symptomatic Management of Huntington’s Disease Open
Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, behavioral, and cognitive impairments and significant impacts on patient quality of life. This evidence-based review, conducted by the Korean Huntington Dise…
View article: Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Masquerading as Charcot-Marie-Tooth Disease: A Case Study and Literature Review of Korean Patients
Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay Masquerading as Charcot-Marie-Tooth Disease: A Case Study and Literature Review of Korean Patients Open
Autosomal-recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is characterized by a triad of cerebellar ataxia, progressive spasticity, and peripheral neuropathy, and a number of pathogenic mutations of SACS have been reported in the …
View article: Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial
Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial Open
Background: Choline alfoscerate (alpha-glycerylphosphorylcholine) is a phospholipid that includes choline, which increases the release of acetylcholine. The ASCOMALVA trial, a combination of donepezil and choline alfoscerate, slowed cognit…
View article: Effect of Korean Red Ginseng on the motor performance and ataxia
Effect of Korean Red Ginseng on the motor performance and ataxia Open
This study presents a preliminary exploration into the effect of Korean Red Ginseng (KRG) on the cerebellum in individuals with cerebellar atrophy. Over a three month-long period, nine subjects received a 4.5g of KRG daily, with assessment…
View article: Gemigliptin, a potent selective dipeptidyl peptidase 4 inhibitor, protects endothelial progenitor cells by oxidative stress via caspase-3 dependent pathway
Gemigliptin, a potent selective dipeptidyl peptidase 4 inhibitor, protects endothelial progenitor cells by oxidative stress via caspase-3 dependent pathway Open
Endothelial progenitor cells (EPCs) are exclusive players in vasculogenesis and endothelial regeneration. EPCs are of two types and their differentiation is mediated by different growth factors. A decrease in EPC number and function causes…
View article: Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia
Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia Open
Ginseng is a traditional herbal medicine used for prevention and treatment of various diseases as a tonic. Recent scientific cohort studies on life prolongation with ginseng consumption support this record, as those who consumed ginseng fo…
View article: Treatment Outcome After Switching From Galcanezumab to Fremanezumab in Patients With Migraine
Treatment Outcome After Switching From Galcanezumab to Fremanezumab in Patients With Migraine Open
Switching between anti-CGRP mAbs (galcanezumab to fremanezumab) yielded a treatment outcome comparable to that reported previously when switching from an anti-CGRP-R mAb (erenumab) to an anti-CGRP mAb (galcanezumab or fremanezumab). The tr…
View article: Exosomes: Membrane-associated proteins, challenges and perspectives
Exosomes: Membrane-associated proteins, challenges and perspectives Open
Membrane proteins determine the precise function of each membrane and, therefore, the function of each cell type. These proteins essential roles in cell physiology, participating in the maintenance of the cell metabolism, its homeostasis o…
View article: Endothelial Progenitor Cells: A Brief Update
Endothelial Progenitor Cells: A Brief Update Open
An enormous amount of current data has suggested involvement of endothelial progenitor cells (EPCs) in neovasculogenesis in both human and animal models. EPC level is an indicator of possible cardiovascular risk such as Alzheimer disease. …
View article: Development of a Heuristic Control Algorithm for Improving Energy Efficiency in Commercial Refrigerated Systems without Indoor Information
Development of a Heuristic Control Algorithm for Improving Energy Efficiency in Commercial Refrigerated Systems without Indoor Information Open
Despite the serious threat of global warming caused by carbon emissions, commercial refrigeration systems that generate cooling are unable to adjust their usage time. Therefore, it is essential to enhance the energy efficiency of refrigera…
View article: Caregiver Burden of Patients With Huntington’s Disease in South Korea
Caregiver Burden of Patients With Huntington’s Disease in South Korea Open
Objective This is the first prospective cohort study of Huntington’s disease (HD) in Korea. This study aimed to investigate the caregiver burden in relation to the characteristics of patients and caregivers.Methods From August 2020 to Febr…
View article: Therapeutic Applications of Plant-Derived Extracellular Vesicles as Antioxidants for Oxidative Stress-Related Diseases
Therapeutic Applications of Plant-Derived Extracellular Vesicles as Antioxidants for Oxidative Stress-Related Diseases Open
Extracellular vesicles (EVs) composed of a lipid bilayer are released from various cell types, including animals, plants, and microorganisms, and serve as important mediators of cell-to-cell communication. EVs can perform a variety of biol…
View article: Enhanced osteogenesis of human urine-derived stem cells by direct delivery of 30Kc19α–Lin28A protein
Enhanced osteogenesis of human urine-derived stem cells by direct delivery of 30Kc19α–Lin28A protein Open
Urine-derived stem cells (USCs) are a promising source for regenerative medicine because of their advantages such as easy and non-invasive collection from the human body, stable expansion, and the potential to differentiate into multiple l…
View article: Balloon Flower Root-Derived Extracellular Vesicles: In Vitro Assessment of Anti-Inflammatory, Proliferative, and Antioxidant Effects for Chronic Wound Healing
Balloon Flower Root-Derived Extracellular Vesicles: In Vitro Assessment of Anti-Inflammatory, Proliferative, and Antioxidant Effects for Chronic Wound Healing Open
Excessive reactive oxygen species (ROS) in wound lesions can lead to oxidative stress and failure of normal wound healing processes, eventually resulting in chronic skin wounds. A multitude of researchers have investigated various natural …
View article: Insulated, Passivated & Adhesively-Promoted Bond Wire Using All-in-One Al2O3 Coating
Insulated, Passivated & Adhesively-Promoted Bond Wire Using All-in-One Al2O3 Coating Open
Wire bonding technology has been dominant over soldering joint method for electronic packages especially for low I/O density due to its assembly simplicity. Bond wires are composed , at most, of a combination of two different metals, which…
View article: Epicranial headache part 1: Primary stabbing headache
Epicranial headache part 1: Primary stabbing headache Open
Background/objective Primary stabbing headache is a common but under-recognized primary headache disorder. The objectives of this review were to provide practical information for better understanding and identification of the disease, sugg…
View article: Increased 10-Year Prevalence of Huntington’s Disease in South Korea: An Analysis of Medical Expenditure Through the National Healthcare System
Increased 10-Year Prevalence of Huntington’s Disease in South Korea: An Analysis of Medical Expenditure Through the National Healthcare System Open
This study found that the actual prevalence of HD in South Korea was higher than previously thought and that patients are in a situation with high medical expenditure that persists over time.
View article: Efficacy and Safety of Galcanezumab as a Preventive Treatment for Episodic Migraine in South Korean Patients: A Post-Hoc Analysis of a Phase 3 Clinical Trial
Efficacy and Safety of Galcanezumab as a Preventive Treatment for Episodic Migraine in South Korean Patients: A Post-Hoc Analysis of a Phase 3 Clinical Trial Open
Galcanezumab treatment demonstrated efficacy and a favorable safety and tolerability profile in South Korean patients with EM.
View article: Driving Profile Optimization Using a Deep Q‐Network to Enhance Electric Vehicle Battery Life
Driving Profile Optimization Using a Deep Q‐Network to Enhance Electric Vehicle Battery Life Open
In the COVID‐19 era, automobiles with internal combustion engines are being replaced by eco‐friendly vehicles. The demand for battery electric vehicles (BEVs) has increased explosively. Treatment of spent batteries has received much attent…
View article: Isolation of Aloe saponaria-Derived Extracellular Vesicles and Investigation of Their Potential for Chronic Wound Healing
Isolation of Aloe saponaria-Derived Extracellular Vesicles and Investigation of Their Potential for Chronic Wound Healing Open
A chronic wound is caused by a failure to progress through the normal phases of wound repair in an orderly and timely manner. To induce skin regeneration while inhibiting chronic inflammation, numerous natural products, and in particular, …
View article: Association of Zolpidem With Increased Mortality in Patients With Brain Cancer: A Retrospective Cohort Study Based on the National Health Insurance Service Database
Association of Zolpidem With Increased Mortality in Patients With Brain Cancer: A Retrospective Cohort Study Based on the National Health Insurance Service Database Open
Zolpidem exposure was significantly associated with increased brain-cancer-specific mortality in patients with brain cancer aged 18-64 years. Further prospective studies are warranted to understand the mechanism underlying the effect of zo…