Mani Kalaivani
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View article: Rapid Identification and Susceptibility Testing Directly From Urine Specimens, Reducing Turnaround Time, a Step Towards Advancing Diagnostic Stewardship
Rapid Identification and Susceptibility Testing Directly From Urine Specimens, Reducing Turnaround Time, a Step Towards Advancing Diagnostic Stewardship Open
Background Urinary tract infections (UTIs) are the most common bacterial infections with a turnaround time (TAT) of 48-72 hours for routine culture and antimicrobial susceptibility testing (AST). Here, we aimed to improve diagnostic stewar…
View article: Stigma, HIV Risk Behavior, and HIV Seropositivity among Hijra and Transgender in India: Insights from Integrated Biological and Behavioral Surveillance
Stigma, HIV Risk Behavior, and HIV Seropositivity among Hijra and Transgender in India: Insights from Integrated Biological and Behavioral Surveillance Open
Background: The hijra and transgender (H/TG) persons have enhanced risk of HIV infection. Objectives: We aimed to explore whether there were any associations between stigma, HIV risk behaviors, and HIV seropositivity among H/TG persons in …
View article: Clinical Profile and Treatment Outcomes of Tumour-Induced Osteomalacia – A Single-Centre Experience
Clinical Profile and Treatment Outcomes of Tumour-Induced Osteomalacia – A Single-Centre Experience Open
Introduction: Tumour-induced osteomalacia (TIO) is rare. At our referral centre, we see a substantial number of TIO. Therefore, we planned to study their profile and treatment outcomes to provide insight in management. Methods: This ambisp…
View article: Assessment of Efficacy of Adjuvant Topical Rituximab Encapsulated in Nanoparticle Gel in Oral Pemphigus Vulgaris: A Randomized, Double-Blind, Placebo-Controlled, Pilot Study
Assessment of Efficacy of Adjuvant Topical Rituximab Encapsulated in Nanoparticle Gel in Oral Pemphigus Vulgaris: A Randomized, Double-Blind, Placebo-Controlled, Pilot Study Open
Background: Oral pemphigus vulgaris (PV) presents with persistent, painful, nonhealing oral erosions, with a slower treatment response compared to cutaneous lesions. Patients and Methods: To assess the efficacy of adjuvant topical rituxima…
View article: Cardio-metabolic traits and its socioeconomic differentials among school children including metabolically obese normal weight phenotypes in India: A post-COVID baseline characteristics of LEAP-C cohort
Cardio-metabolic traits and its socioeconomic differentials among school children including metabolically obese normal weight phenotypes in India: A post-COVID baseline characteristics of LEAP-C cohort Open
Background Cardio-metabolic risks emerge in early life and progress further in adult life. In recent times, COVID-19 pandemic aggravated risks owing to poor food security and diet quality. We aimed to assess the prevalence of cardiometabol…
View article: Prevalence of knee osteoarthritis among elderly persons in India: A systematic review and meta-analysis
Prevalence of knee osteoarthritis among elderly persons in India: A systematic review and meta-analysis Open
A BSTRACT Background: Osteoarthritis (OA) is the most common cause of joint pain among the elderly population. It deteriorates their quality of life and poses economic burden to the family and the nation. Furthermore with increasing life e…
View article: Comparison of Different Body Mass Index Classification Tools to Identify Underweight and Overweight among Young Girls in Rural Haryana
Comparison of Different Body Mass Index Classification Tools to Identify Underweight and Overweight among Young Girls in Rural Haryana Open
Malnutrition is prevalent and impactful among young Indian girls aged under 18 years. Systematic errors have been observed in body mass index (BMI) classification among these girls. We assessed anthropometry of 185 young girls (15–17 years…
View article: Identification of bacterial pathogens in patients with chronic obstructive pulmonary disease (COPD) with special reference to Mycoplasma pneumoniae, Chlamydia pneumoniae and Legionella pneumophila
Identification of bacterial pathogens in patients with chronic obstructive pulmonary disease (COPD) with special reference to Mycoplasma pneumoniae, Chlamydia pneumoniae and Legionella pneumophila Open
Background Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality throughout the world. COPD is often accompanied by acute exacerbations [AECOPD] where 70% of it is caused by aerobic bacteria, 30% due to v…
View article: Triple Burden of Malnutrition among Young Women Aged 15–24 Years in a Rural Area of Haryana
Triple Burden of Malnutrition among Young Women Aged 15–24 Years in a Rural Area of Haryana Open
Background: Malnutrition is a major problem, particularly among young women (aged 15–24 years) in rural India. Malnutrition not only affects their own health but may also affect the health of their future offspring. In India, there is a tr…
View article: A phase II, randomized, open-labeled study to evaluate low-dose pembrolizumab in addition to neoadjuvant chemotherapy for triple-negative breast cancer (TNBC)
A phase II, randomized, open-labeled study to evaluate low-dose pembrolizumab in addition to neoadjuvant chemotherapy for triple-negative breast cancer (TNBC) Open
Clinical Trials Registry of India-CTRI/2024/01/062088.
View article: VENTIlatory strategies for patients with severe traumatic brain injury in the LOw- and Middle-Income CountrieS. The VENTILOMICS survey
VENTIlatory strategies for patients with severe traumatic brain injury in the LOw- and Middle-Income CountrieS. The VENTILOMICS survey Open
The findings suggest a consistent approach to lung-protective ventilation across low-and middle-income countries, with notable variations influenced by local resources and economic status. This study highlights the necessity for tailored r…
View article: A rapid CRISPR/Cas12a-based assay for the detection of HIV-1 Indian Clade-C infections
A rapid CRISPR/Cas12a-based assay for the detection of HIV-1 Indian Clade-C infections Open
Early detection of HIV-1 infection is crucial to initiate anti-retroviral therapy (ART) to suppress viremia and disease progression. Herein, we developed a CRISPR/Cas12a-based HIV-1 detection assay by optimizing components for a coupled is…
View article: Cardiovascular Health Metrics of Spouses of Indian Women with a History of Gestational Diabetes and Diabetes in Pregnancy: Results from CHIP-F Study
Cardiovascular Health Metrics of Spouses of Indian Women with a History of Gestational Diabetes and Diabetes in Pregnancy: Results from CHIP-F Study Open
Nearly three in five young couples evaluated in the study showed concordance for adverse cardiovascular scores. The cardiovascular risk in men increased in a graded manner across the increasing severity of antenatal glycemic categories of …
View article: Measuring up: Ensuring Intra- and Interobserver Reliability in Stretched Penile Length with the SPLINT Technique
Measuring up: Ensuring Intra- and Interobserver Reliability in Stretched Penile Length with the SPLINT Technique Open
A BSTRACT Background: A discrepancy between the true and measured value of stretched penile length (SPL) may be a result of errors that can either be systematic or random. Hence, it becomes important to focus on the quality of measurements…
View article: Comparative evaluation of autologous tissue-engineered ocular and oral mucosal tissue grafts- a prospective randomized controlled trial
Comparative evaluation of autologous tissue-engineered ocular and oral mucosal tissue grafts- a prospective randomized controlled trial Open
Background Bilateral ocular surface disease resulting from Stevens Johnson Syndrome (SJS) and chemical injuries are visually debilitating and difficult to treat. Ocular surface reconstruction by various means has been reported with variabl…
View article: 7807 Significance of Assessing QTc Interval in Chronic Hypoparathyroidism and its Clinical and Biochemical Correlates
7807 Significance of Assessing QTc Interval in Chronic Hypoparathyroidism and its Clinical and Biochemical Correlates Open
Disclosure: P.V. Namjoshi: None. S. Saha: None. V. Sharma: None. R. Narang: None. K. Mani: None. R. Goswami: None. Background: Patients with chronic hypoparathyroidism (cHypoPT) and hypocalcemia are at risk of QTc prolongation and life-thr…
View article: 9307 Significance of Assessing QTc Interval in Chronic Hypoparathyroidism and its Clinical and Biochemical Correlates
9307 Significance of Assessing QTc Interval in Chronic Hypoparathyroidism and its Clinical and Biochemical Correlates Open
Disclosure: P.V. Namjoshi: None. S. Saha: None. V. Sharma: None. R. Goswami: None. R. Narang: None. K. Mani: None. Background: Patients with chronic hypoparathyroidism (cHypoPT) and hypocalcemia are at risk of QTc prolongation and life-thr…
View article: Evaluation of Predictors of Response to Ovulation Induction Using Letrozole in Women with Polycystic Ovary Syndrome: A Prospective Cohort Study
Evaluation of Predictors of Response to Ovulation Induction Using Letrozole in Women with Polycystic Ovary Syndrome: A Prospective Cohort Study Open
A BSTRACT Background: Ovulation induction (OI) in patients with polycystic ovary syndrome (PCOS) remains challenging, and several biomarkers have been evaluated for their ability to predict ovulation. The predictive ability of candidate bi…
View article: Anaemia and selected micronutrient deficiencies among young women in rural North India – A community-based study
Anaemia and selected micronutrient deficiencies among young women in rural North India – A community-based study Open
A BSTRACT Introduction: Anaemia is a major problem which affects half of young Indian women, impacting their health, education, and offspring. Despite ongoing efforts, a comprehensive understanding of anaemia remains limited. This study ai…
View article: Effect of Two Different Mouth-rinses on Plaque Microbial Counts
Effect of Two Different Mouth-rinses on Plaque Microbial Counts Open
View article: A RCT to Determine the Efficacy of Supplementing Nano D3 Buccal Spray vs Nano D3, Fat-Soluble D3 Tablet Daily for 3 Months in Vitamin D-deficient/Insufficient Indian Adults
A RCT to Determine the Efficacy of Supplementing Nano D3 Buccal Spray vs Nano D3, Fat-Soluble D3 Tablet Daily for 3 Months in Vitamin D-deficient/Insufficient Indian Adults Open
View article: The outcome of surgery for congenital heart disease in India: A systematic review and metanalysis
The outcome of surgery for congenital heart disease in India: A systematic review and metanalysis Open
Background: The mortality risks of children undergoing various cardiac surgeries for congenital heart disease (CHD) in India are not well defined. We conducted a systematic review and meta-analysis to estimate the inhospital mortality of v…
View article: Analyzing the States of Brain under Anesthesia Using ANES-metanet based on Deep Learning Models
Analyzing the States of Brain under Anesthesia Using ANES-metanet based on Deep Learning Models Open
Monitoring the depth of unconsciousness during anesthesia is beneficial in both clinical settings and neuroscience investigations to understand brain mechanisms. Electroencephalogram (EEG) has been used as an objective means of characterizi…
View article: Robotic-assisted Versus Conventional Laparoscopic Hysterectomy for Benign Gynecological Conditions: A Systematic Review and Meta-analysis
Robotic-assisted Versus Conventional Laparoscopic Hysterectomy for Benign Gynecological Conditions: A Systematic Review and Meta-analysis Open
A BSTRACT Background: Minimally invasive gynecologic surgery is safe and feasible procedure for benign gynaecological conditions with less morbidity. Objective: To determine the best approach in benign gynecology and establish superiority …
View article: Chronic Illnesses and Depression among Community-based Adolescents in Rural Haryana, India
Chronic Illnesses and Depression among Community-based Adolescents in Rural Haryana, India Open
Evidence on the association of chronic illnesses with depression among adolescents in the Indian community setting is limited. A simple random sample of 583 adolescents, comprising 56.6% of boys and 43.4% of girls, were interviewed on home…
View article: Investigating the Role of Palliative Care Education in Improving the Life Quality of Women with Breast Cancer
Investigating the Role of Palliative Care Education in Improving the Life Quality of Women with Breast Cancer Open
Considering the high prevalence of breast cancer and its effect on the life quality of affected people, the current study was done to investigate the role of palliative care education in improving the life quality of women with breast canc…
View article: Understanding the Effect of Rajyog Meditation on Biomolecular and Behavioural Co-relates of Stress in Patients Undergoing Coronary Artery Bypass Graft Surgery
Understanding the Effect of Rajyog Meditation on Biomolecular and Behavioural Co-relates of Stress in Patients Undergoing Coronary Artery Bypass Graft Surgery Open
Background: The role of psychological health in impacting the risk factors for heart disease is well recognized. Patients undergoing corrective surgery for Coronary Artery Disease undergo much anxiety and depression that negatively impact …
View article: Looking Beyond Toxicities
Looking Beyond Toxicities Open
Aim: In addition to the well-known toxicities of treatment, survivors of pediatric solid tumors can also develop other health-related conditions. They may either be an indirect consequence of therapy or could be unrelated to their prior hi…
View article: Application of isotonic regression in estimating EDg and its 95% confidence interval by bootstrap method for a biased coin up-and-down sequential dose-finding design
Application of isotonic regression in estimating EDg and its 95% confidence interval by bootstrap method for a biased coin up-and-down sequential dose-finding design Open
INTRODUCTION Newer anaesthetic drugs introduced in practice and older drugs for novel route or indication has led to the need to determine the optimal dose. In this context, two most recent studies, for example, estimated the effective dos…
View article: Cardiometabolic profile of women with a history of overt diabetes compared to gestational diabetes and normoglycemia in index pregnancy: Results from CHIP‐F study
Cardiometabolic profile of women with a history of overt diabetes compared to gestational diabetes and normoglycemia in index pregnancy: Results from CHIP‐F study Open
Purpose We aimed to evaluate the prevalence of postpartum diabetes among women with a history of overt diabetes in pregnancy (ODiP) and compare with women having a history of gestational diabetes mellitus (GDM) and normoglycemia in pregnan…