Manik C. Ghosh
YOU?
Author Swipe
View article: The iron chaperone poly(rC)-binding protein 1 regulates iron efflux through intestinal ferroportin in mice
The iron chaperone poly(rC)-binding protein 1 regulates iron efflux through intestinal ferroportin in mice Open
Iron is an essential nutrient required by all cells but used primarily for red blood cell production. Because humans have no effective mechanism for ridding the body of excess iron, the absorption of dietary iron must be precisely regulate…
View article: Supplementary Table 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Table 1 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Table 1. Primer sequences used in quantitative Real-Time PCR analysis.
View article: Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Autotaxin (ENPP2/ATX) and lysophosphatidic acid (LPA) receptors represent two key players in regulating cancer progression. The present study sought to understand the mechanistic role of LPA G protein–coupled receptors (GPCR), not only in …
View article: Supplementary Figure 4 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 4 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 4. Effect of BMP22 on the basal invasion of B16F10 cells across a matrigel layer. Data are representative of an experiment performed twice in quadruplicates and are expressed as mean {plus minus} SD. *Denotes p value <…
View article: Supplementary Figure 2 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 2 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 2. LPA1-5 receptor profiling in whole lung tissue isolated from WT, LPA1-, LPA2- and LPA5KO mice, respectively using quantitative real-time PCR. Data are expressed as mean {plus minus} SEM (n = 3 mice).
View article: Supplementary Figure 4 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 4 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 4. Effect of BMP22 on the basal invasion of B16F10 cells across a matrigel layer. Data are representative of an experiment performed twice in quadruplicates and are expressed as mean {plus minus} SD. *Denotes p value <…
View article: Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 3. (A) ATX and LPA receptor profiling in B16F10 cells transduced with GFP lentivirus using quantitative real-time PCR. Data are expressed as mean {plus minus} SD of an experiment performed twice in quadruplicates. (B) …
View article: Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Data from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Autotaxin (ENPP2/ATX) and lysophosphatidic acid (LPA) receptors represent two key players in regulating cancer progression. The present study sought to understand the mechanistic role of LPA G protein–coupled receptors (GPCR), not only in …
View article: Supplemental Figure Legends from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplemental Figure Legends from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplemental Figure Legends. Supplemental Figure Legends
View article: Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 3 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 3. (A) ATX and LPA receptor profiling in B16F10 cells transduced with GFP lentivirus using quantitative real-time PCR. Data are expressed as mean {plus minus} SD of an experiment performed twice in quadruplicates. (B) …
View article: Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 5. ATX and LPA receptor profiling in isolated rat alveolar type I-like (A) or type II (B) epithelial cells. Note that expression levels in type II alveolar cells are approximately 10-fold lower than in type I-like cell…
View article: Supplementary Figure 2 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 2 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 2. LPA1-5 receptor profiling in whole lung tissue isolated from WT, LPA1-, LPA2- and LPA5KO mice, respectively using quantitative real-time PCR. Data are expressed as mean {plus minus} SEM (n = 3 mice).
View article: Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis
Supplementary Figure 5 from Autotaxin and LPA<sub>1</sub> and LPA<sub>5</sub> Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis Open
Supplementary Figure 5. ATX and LPA receptor profiling in isolated rat alveolar type I-like (A) or type II (B) epithelial cells. Note that expression levels in type II alveolar cells are approximately 10-fold lower than in type I-like cell…
View article: Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia
Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia Open
Cardiomyopathy is a primary cause of death in Friedreich ataxia (FRDA) patients with defective iron-sulfur cluster (ISC) biogenesis due to loss of functional frataxin and in rare patients with functional loss of other ISC biogenesis factor…
View article: Comparative Study of Medical Devices in USA, Europe and India
Comparative Study of Medical Devices in USA, Europe and India Open
Any medical equipment must get a marketing authorisation from a regulatory authority before it can be sold. Obtaining authorization is a lengthy, multi-step process that requires relevant authorities to review material. After analyzing the…
View article: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia Open
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicit…
View article: Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis
Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis Open
Significance Adaptive thermogenesis is a metabolic switch that converts the metabolic status of fat tissue from energy conservation to energy release into heat, thereby significantly attenuating the energy burden of obesity and diabetes. I…
View article: Mechanisms of cellular iron sensing, regulation of erythropoiesis and mitochondrial iron utilization
Mechanisms of cellular iron sensing, regulation of erythropoiesis and mitochondrial iron utilization Open
View article: Inotuzumab Ozogamicin Monotherapy as an Outpatient Salvage Treatment in Relapsed Refractory B-Cell Acute Lymphoblastic Leukemia: Compassionate Access
Inotuzumab Ozogamicin Monotherapy as an Outpatient Salvage Treatment in Relapsed Refractory B-Cell Acute Lymphoblastic Leukemia: Compassionate Access Open
Relapsed and refractory (RR) acute lymphoblastic leukemia (ALL) poses unique and difficult challenges to a practicing clinician in India where access to novel immunotherapies is limited. Between 2017 and 2020, eight patients with B-cell AL…
View article: Hyperactivation of mTORC1 in a Cardiac Hypertrophy Animal Model of Friedreich's Ataxia
Hyperactivation of mTORC1 in a Cardiac Hypertrophy Animal Model of Friedreich's Ataxia Open
View article: Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases
Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases Open
Polycythemia and pulmonary hypertension are 2 human diseases for which better therapies are needed. Upregulation of hypoxia-inducible factor-2α (HIF-2α) and its target genes, erythropoietin (EPO) and endothelin-1, causes polycythemia and p…
View article: Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis
Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis Open
Background and Aims Iron is essential yet also highly chemically reactive and potentially toxic. The mechanisms that allow cells to use iron safely are not clear; defects in iron management are a causative factor in the cell‐death pathway …
View article: Reply: IREB2-associated neurodegeneration
Reply: IREB2-associated neurodegeneration Open
View article: Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS
Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS Open
In macrophages, cellular iron metabolism status is tightly integrated with macrophage phenotype and associated with mitochondrial function. However, how molecular events regulate mitochondrial activity to integrate regulation of iron metab…
View article: Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome
Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome Open
Disruption of cellular iron homeostasis can contribute to neurodegeneration. In mammals, two iron-regulatory proteins (IRPs) shape the expression of the iron metabolism proteome. Targeted deletion of Ireb2 in a mouse model causes profoundl…
View article: Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice
Infused wild-type macrophages reside and self-renew in the liver to rescue the hemolysis and anemia of Hmox1-deficient mice Open
Heme oxygenase 1 (HMOX1), the inducible enzyme that catabolizes the degradation of heme into biliverdin, iron, and carbon monoxide, plays an essential role in the clearance of senescent and damaged red blood cells, systemic iron homeostasi…
View article: Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress
Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress Open
Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroi…
View article: TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation
TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation Open
Key Points TLR activation suppresses expression of Fe-S cluster biogenesis factors NFS1, ISCU, HSC20, FXN, ISD11, GLRX5, CIAO1, FAM96A, and FAM96B. Restriction of Fe-S cluster biogenesis not only impairs oxidative metabolism but also modul…
View article: Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk
Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk Open
Iron's grip on malaria Malaria parasites have coevolved with their human and mammalian hosts. These Plasmodium species invade the iron-rich environment of red blood cells. Zhang et al. found that the iron transporter ferroportin persists o…
View article: Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia
Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia Open
Chuvash polycythemia is an inherited disease caused by a homozygous germline VHLR200W mutation, which leads to impaired degradation of HIF2α, elevated levels of serum erythropoietin, and erythrocytosis/polycythemia. This phenotype is recap…