Manikandan Sethuraman
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View article: Alterations in Cardiac Function During Hemodynamic Fluctuations in Major Neurosurgery: An Evaluation Using Transesophageal Echocardiography
Alterations in Cardiac Function During Hemodynamic Fluctuations in Major Neurosurgery: An Evaluation Using Transesophageal Echocardiography Open
View article: The Effect of Total Intravenous Anesthesia and Inhalational Anesthesia on the Markers of Neuronal and Systemic Inflammation in Patients Undergoing Resection of Supratentorial Gliomas (TINSI Trial): Study Protocol for a Randomized Controlled Trial
The Effect of Total Intravenous Anesthesia and Inhalational Anesthesia on the Markers of Neuronal and Systemic Inflammation in Patients Undergoing Resection of Supratentorial Gliomas (TINSI Trial): Study Protocol for a Randomized Controlled Trial Open
Brain tumors and craniotomy surgeries can induce both systemic and neuronal inflammation. Currently, there is a limited amount of literature addressing the influence of anesthetic agents on neuronal and systemic inflammation in neurosurgic…
View article: Evaluating the Effectiveness and Economic Viability of a Novel Population-Based Colorectal Cancer Screening Strategy
Evaluating the Effectiveness and Economic Viability of a Novel Population-Based Colorectal Cancer Screening Strategy Open
Background: Colorectal cancer (CRC) remains the second leading cause of cancer-related deaths in the United States, with disparities in screening disproportionately affecting socioeconomically disadvantaged and underrepresented populations…
View article: The Advancement of Scaffolds Through 3D Printing Techniques for Tissue Engineering Applications
The Advancement of Scaffolds Through 3D Printing Techniques for Tissue Engineering Applications Open
An Increase in global populations at higher rates has emphasised the necessity for more advanced regenerative medicine approaches. Based on the application of tissue-engineered scaffolds with an adhesion, proliferation, and branching templ…
View article: Postoperative Hyperglycemia with Ketosis Sans Acidemia in a Child Immediately Following Fourth Ventricular Medulloblastoma Resection: Anesthetic Concerns and Intensive Care Management
Postoperative Hyperglycemia with Ketosis Sans Acidemia in a Child Immediately Following Fourth Ventricular Medulloblastoma Resection: Anesthetic Concerns and Intensive Care Management Open
Postoperative hyperglycemia with ketosis immediately following fourth ventricular medulloblastoma surgery for a non-diabetic child with normal intraoperative blood glucose, is an uncommon clinical entity, and has seldom been reported in th…
View article: Efficacy and safety of stem cell therapy in patients with Diabetes Mellitus – A Systematic Review and Meta-analysis
Efficacy and safety of stem cell therapy in patients with Diabetes Mellitus – A Systematic Review and Meta-analysis Open
Background To support the development of a national guideline on stem cell therapy, the Department of Health Research, India, commissioned this systematic review to evaluate the efficacy and safety of various stem cell types in patients wi…
View article: Evaluation of Cardiac Function in Patients with Supratentorial Tumors and Raised Intracranial Pressure: HABIT-ICP, a Prospective Observational Study Using Transthoracic Echocardiography
Evaluation of Cardiac Function in Patients with Supratentorial Tumors and Raised Intracranial Pressure: HABIT-ICP, a Prospective Observational Study Using Transthoracic Echocardiography Open
Objective An acute increase in intracranial pressure (ICP) has been shown to affect cardiac function due to brain ischemia and the associated increased sympathetic activity. However, there is limited literature on the changes in cardiac fu…
View article: Serial Assessment of Hemodynamic and Cerebrovascular Changes After Administration of Mannitol in Postoperative Neurosurgical Patients in the Intensive Care Unit: A Combined Transthoracic and Transcranial Color Doppler Study
Serial Assessment of Hemodynamic and Cerebrovascular Changes After Administration of Mannitol in Postoperative Neurosurgical Patients in the Intensive Care Unit: A Combined Transthoracic and Transcranial Color Doppler Study Open
Mannitol administration at 0.5 g/kg in postoperative neurosurgical patients transiently improves cerebral perfusion without causing significant hemodynamic instability. This study underscores the importance of monitoring both cerebrovascul…
View article: A prospective observational study to compare and evaluate delta down, aortic velocity time integral variability, and superior vena cava collapsibility index as predictors of fluid responsiveness in patients with supratentorial brain tumors undergoing elective neurosurgery
A prospective observational study to compare and evaluate delta down, aortic velocity time integral variability, and superior vena cava collapsibility index as predictors of fluid responsiveness in patients with supratentorial brain tumors undergoing elective neurosurgery Open
Background: Patients undergoing surgical resection of brain tumors frequently exhibit a spectrum of hemodynamic fluctuations necessitating careful fluid management. This study aimed to evaluate the feasibility of dynamic predictors of flui…
View article: Optimizing Comfort and Efficiency: The Crucial Role of Ergonomics for Neuroanesthesiologists in the Operating Room
Optimizing Comfort and Efficiency: The Crucial Role of Ergonomics for Neuroanesthesiologists in the Operating Room Open
Ergonomic principles, when applied effectively, reduce the risk of musculoskeletal injuries, fatigue, and discomfort among neuroanesthesiologists who spend extended hours in the operating room. Properly designed workstations and equipment …
View article: Evaluation of Cerebral Perfusion Pressure, Cerebral Blood Flow, and Cerebral Oxygenation at Different Head of Bed Positions Using Transcranial Doppler and Near-Infrared Spectroscopy in Postoperative Neurosurgical Patients
Evaluation of Cerebral Perfusion Pressure, Cerebral Blood Flow, and Cerebral Oxygenation at Different Head of Bed Positions Using Transcranial Doppler and Near-Infrared Spectroscopy in Postoperative Neurosurgical Patients Open
Postoperative nursing with positions up to 60° HOB can be tried in indicated patients following elective neurosurgery when complemented with CBF velocity and rSO2 monitoring and in whom CPP-guided therapy is not preferred.
View article: Periprocedural management of patients presenting for neurointerventional procedures using flow diverters for complex intracranial aneurysms: An anesthetist’s perspective - A narrative review
Periprocedural management of patients presenting for neurointerventional procedures using flow diverters for complex intracranial aneurysms: An anesthetist’s perspective - A narrative review Open
Complex intracranial aneurysms pose significant challenges in the realm of neurointervention, necessitating meticulous planning and execution. This article highlights the crucial roles played by anesthetists in these procedures, including …
View article: Non-opioid versus Opioid Peri-operative Analgesia In Neurosurgery (NOPAIN): Study protocol for a multi-centric randomised controlled trial
Non-opioid versus Opioid Peri-operative Analgesia In Neurosurgery (NOPAIN): Study protocol for a multi-centric randomised controlled trial Open
Background and Aims: Many patients suffer from post-operative pain after neurosurgery despite using intra-operative opioids. Opioid side effects are problematic in neurosurgical patients. Hence, non-opioid alternatives for the management o…
View article: Evaluation of markers of cerebral oxygenation and metabolism in patients undergoing clipping of cerebral aneurysm under total intravenous anesthesia versus inhalational anesthesia: A prospective randomized trial (COM-IVIN trial)
Evaluation of markers of cerebral oxygenation and metabolism in patients undergoing clipping of cerebral aneurysm under total intravenous anesthesia versus inhalational anesthesia: A prospective randomized trial (COM-IVIN trial) Open
INTRODUCTION: Anesthetic goals in patients undergoing clipping of cerebral aneurysm include maintenance of cerebral blood flow, oxygenation, and metabolism to avoid cerebral ischemia and maintenance of hemodynamic stability. We intend to s…
View article: Role of multimodal monitoring in the management of patients undergoing complex intracranial bypass procedures – A case series and literature review
Role of multimodal monitoring in the management of patients undergoing complex intracranial bypass procedures – A case series and literature review Open
Patients undergoing complex intracranial neurovascular procedures continue to have a high mortality rate. Individualised goal-directed cerebral resuscitation employing multimodality neuromonitoring may impact these patients’ treatment and …
View article: Autologous versus allogeneic blood transfusion: A comparative study of the peri-operative outcomes in a tertiary care hospital in South India amidst the COVID-19 pandemic
Autologous versus allogeneic blood transfusion: A comparative study of the peri-operative outcomes in a tertiary care hospital in South India amidst the COVID-19 pandemic Open
View article: Recent advancements in the practice of neuroanaesthesia and neurocritical care: An update
Recent advancements in the practice of neuroanaesthesia and neurocritical care: An update Open
The practice of neuroanaesthesia has expanded significantly in recent years to keep up with various challenges posed in the perioperative care of patients for neurosurgical, interventional, neuroradiological, and diagnostic procedures. Tec…
View article: Sequential events of asystole and cranial nerve monitor induced narrow QRS complex ECG artefacts: An uncommon combination during a common neurosurgery
Sequential events of asystole and cranial nerve monitor induced narrow QRS complex ECG artefacts: An uncommon combination during a common neurosurgery Open
Sir, Intraoperative evoked potential monitors and cranial nerve monitoring during posterior fossa surgeries have become the standard of care. These neuromonitors can produce electrocardiographic (ECG) artefacts mimicking ECG variations occ…
View article: Electrocardiographic changes in patients with raised intracranial pressure from supratentorial brain tumors
Electrocardiographic changes in patients with raised intracranial pressure from supratentorial brain tumors Open
Objectives: A wide variety of electrocardiographic (ECG) changes has been described in the context of neurological catastrophe. There has been diverse and plentiful literature emphasizing the cardiac changes in acute cerebrovascular events…
View article: At the Eye of the Hurricane! Perioperative Management of an Unoptimized Metastatic Pheochromocytoma Presenting for Emergency Neurosurgery
At the Eye of the Hurricane! Perioperative Management of an Unoptimized Metastatic Pheochromocytoma Presenting for Emergency Neurosurgery Open
Metastatic pheochromocytoma (PCC) is a rare entity arising from extra-adrenal tissue. We report the perioperative management of a young woman presenting with metastatic PCC to the vertebral body resulting in vertebral collapse and spinal c…
View article: Anesthetic Implications of Nephrotic Syndrome in Neurosurgical Practice
Anesthetic Implications of Nephrotic Syndrome in Neurosurgical Practice Open
Nephrotic syndrome (NS) is a common medical disorder especially in pediatric population with hypoproteinemia as an important feature. NS has multisystem involvement and multiple organ effects due to the disease or the treatment itself, whi…
View article: A Rare Case of Drug Interaction Presenting as Perioperative Hyperthermia in a Patient Presenting for Neurosurgery
A Rare Case of Drug Interaction Presenting as Perioperative Hyperthermia in a Patient Presenting for Neurosurgery Open
Perioperative hyperthermia has many differential diagnoses. This case report describes the rare causation of perioperative hyperthermia in a patient presenting for epilepsy surgery. The patient had two episodes of hyperthermia, initially p…
View article: Anesthetic uncertainties in a child with multiple epidural hematoma immediately following brain tumour resection
Anesthetic uncertainties in a child with multiple epidural hematoma immediately following brain tumour resection Open
View article: Anaesthesia for ventriculoperitoneal shunt surgery in a craniovertebral junction anomaly patient with arrested hydrocephalus: Stability is safety
Anaesthesia for ventriculoperitoneal shunt surgery in a craniovertebral junction anomaly patient with arrested hydrocephalus: Stability is safety Open
View article: Decoding the Onset of Intraoperative Normal Pressure Perfusion Breakthrough with Near-Infrared Spectroscopy and Jugular Venous Oxygen Saturation Catheter in a Case of Arteriovenous Malformation Surgery
Decoding the Onset of Intraoperative Normal Pressure Perfusion Breakthrough with Near-Infrared Spectroscopy and Jugular Venous Oxygen Saturation Catheter in a Case of Arteriovenous Malformation Surgery Open
Multimodal monitoring can be a useful tool to design an appropriate anesthesia technique in the intraoperative period during the surgical excision of an intracerebral arteriovenous malformation (AVM). Intraoperatively, hyperperfusion syndr…
View article: Anesthetic Management of Hashimoto's Encephalopathy Presenting for Spine Surgery
Anesthetic Management of Hashimoto's Encephalopathy Presenting for Spine Surgery Open
Hashimoto's encephalopathy (HE) is a rare neuroendocrine disorder, and there are no reports regarding anesthetic implications in a patient diagnosed with HE. These patients can have a plethora of systemic manifestations involving cardiovas…
View article: Fluid Responsiveness to Passive Leg Raising in Patients with and without Coronary Artery Disease: A Prospective Observational Study
Fluid Responsiveness to Passive Leg Raising in Patients with and without Coronary Artery Disease: A Prospective Observational Study Open
Introduction: Hemodynamic stability and fluid responsiveness (FR) assume importance in perioperative management of patients undergoing major surgery. Passive leg raising (PLR) is validated in assessing FR in intensive care unit patients. V…
View article: Acute Sialadenitis and Threatened Airway following Posterior Fossa Surgery
Acute Sialadenitis and Threatened Airway following Posterior Fossa Surgery Open
Anesthesia mumps (also known as acute sialadenitis) is a rare postoperative complication related to extreme rotation or flexion of the head during surgery.[1] Acute sialadenitis causing acute airway obstruction and requiring emergent trach…
View article: Snippets on Disinfection of Anesthesia Equipment during COVID-19 Pandemic
Snippets on Disinfection of Anesthesia Equipment during COVID-19 Pandemic Open
In the backdrop of the ongoing COVID-19, there is an ever-increasing trend in the Western world toward the application of single-use or disposable equipment to prevent cross infection. However, for a country like ours, this may not be feas…
View article: Finding the Calm in the Chaos: An Institutional Protocol for Anesthetic Management of a Patient for Neurosurgery during Coronavirus Disease 2019 Pandemic
Finding the Calm in the Chaos: An Institutional Protocol for Anesthetic Management of a Patient for Neurosurgery during Coronavirus Disease 2019 Pandemic Open
“Coronavirus disease 2019” (COVID-19) transmitted by a novel coronavirus via contact or droplet spread is a highly infectious disease, the containment of which requires vigilance and stringent infection control policies. In the backdrop of…