Manish Bajaj
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View article: A Rare Case of Intracranial Hemorrhage Mimicking a Neoplasm in a Child With Hereditary Hemorrhagic Telangiectasia
A Rare Case of Intracranial Hemorrhage Mimicking a Neoplasm in a Child With Hereditary Hemorrhagic Telangiectasia Open
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by abnormal blood vessel formation, resulting in the development of arteriovenous malformations and telangiectasias throughout the body. We present…
View article: Hypoxic-Ischemic Encephalopathy and Beyond: A Pictorial Review of Neuroimaging Findings in Neonatal Encephalopathy
Hypoxic-Ischemic Encephalopathy and Beyond: A Pictorial Review of Neuroimaging Findings in Neonatal Encephalopathy Open
View article: A Practical Guide to Microtia Scoring: Step-by-Step
A Practical Guide to Microtia Scoring: Step-by-Step Open
Microtia/aural atresia reconstruction surgery focuses on improving hearing and cosmesis in patients with microtia, aural atresia, and aural stenosis. Preoperative evaluation of microtia with high-resolution CT plays an important role in as…
View article: Comparative Study of Intramedullary Flexible Nailing and External Fixator Result in the Management of Fractures Tibial Shaft. (Gustilo type II, type IIIA, and type IIIB)
Comparative Study of Intramedullary Flexible Nailing and External Fixator Result in the Management of Fractures Tibial Shaft. (Gustilo type II, type IIIA, and type IIIB) Open
Background:Open tibial fractures, usually caused by high-energy trauma, are among the most common long bone fractures. Clinically, the treatment of open tibial fractures remains a major therapeutic problem for surgeons because of the poor …
View article: Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial
Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial Open
Background Recurrent brain tumors are the leading cause of cancer death in children. Indoleamine 2,3-dioxygenase (IDO) is a targetable metabolic checkpoint that, in preclinical models, inhibits anti-tumor immunity following chemotherapy. M…
View article: CTIM-32. FIRST-IN-CHILDREN PHASE 1 TRIAL OF INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH PEDIATRIC BRAIN TUMORS: ANALYSIS OF SAFETY, TOLERABILITY, AND 5-YEAR OUTCOME
CTIM-32. FIRST-IN-CHILDREN PHASE 1 TRIAL OF INDOXIMOD-BASED CHEMO-IMMUNOTHERAPY FOR PATIENTS WITH PEDIATRIC BRAIN TUMORS: ANALYSIS OF SAFETY, TOLERABILITY, AND 5-YEAR OUTCOME Open
BACKGROUND Recurrent brain tumors are the leading cause of cancer death in children. We conducted a first-in-children, two-institution, Phase 1 open-label dose-confirmation study using a 3 + 3 design, with expansion cohorts, to determine t…
View article: IMMU-04. FIRST-IN-CHILDREN PHASE 1B STUDY USING THE IDO PATHWAY INHIBITOR INDOXIMOD IN COMBINATION WITH RADIATION AND CHEMOTHERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIPG (NCT02502708, NLG2105)
IMMU-04. FIRST-IN-CHILDREN PHASE 1B STUDY USING THE IDO PATHWAY INHIBITOR INDOXIMOD IN COMBINATION WITH RADIATION AND CHEMOTHERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIPG (NCT02502708, NLG2105) Open
Background Diffuse intrinsic pontine glioma (DIPG) is a uniformly fatal brain tumor with no available cure. Indoximod blocks the IDO (indoleamine 2,3-dioxygenase) pathway, thereby reversing IDO-mediated immune suppression in the tumor micr…
View article: Prenatal diagnosis and perinatal management of a bilateral anterior congenital diaphragmatic hernia
Prenatal diagnosis and perinatal management of a bilateral anterior congenital diaphragmatic hernia Open
Sir, Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that allows abdominal viscera to herniate into the thorax resulting in pulmonary hypoplasia.[1] CDH occurs in one of 2000–3000 births.[2] About 97% of CD…