Manish K. Jha
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View article: Hysteroscopy: The Uterine Stethoscope Decoding Implantation Failures
Hysteroscopy: The Uterine Stethoscope Decoding Implantation Failures Open
Objectives: To offer or not to offer hysteroscopy has remained an important question among clinicians treating infertility. With this question, we studied the impact of hysteroscopic diagnosis and treatment of pathologies in terms of impro…
View article: Association of Habenula Activity and Volume with Pediatric Irritability: Inconsistent Parenting as a Moderator
Association of Habenula Activity and Volume with Pediatric Irritability: Inconsistent Parenting as a Moderator Open
Irritability significantly impacts mental health and well-being of youth and their families, and is associated with adverse concurrent and future outcomes. Brain abnormalities in the reward system is a potential mechanism underlying irrita…
View article: Towards causal inference-based antidepressant selection with brain and blood biomarkers
Towards causal inference-based antidepressant selection with brain and blood biomarkers Open
This report sought to employ multi-modal integration of pre-treatment brain (electroencephalogram, resting-state functional magnetic resonance imaging) and blood (immune and metabolic) biomarkers to facilitate causal inference-based treatm…
View article: Association between Body Mass Index, age at Menarche with Skeletal Maturity Indicators using Hand Wrist Radiograph in Bengali Female Population: A Cross-sectional Study
Association between Body Mass Index, age at Menarche with Skeletal Maturity Indicators using Hand Wrist Radiograph in Bengali Female Population: A Cross-sectional Study Open
Introduction: Estimation and use of craniofacial growth is crucial in addressing skeletal discrepancies for orthodontic correction of young and growing children. It is crucial to determine each patient’s skeletal age and compare it to thei…
View article: A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder
A Phase 2 Randomized Trial of NBI-1065846 (TAK-041) in Patients With Anhedonia Associated With Major Depressive Disorder Open
Background: Anhedonia is a core symptom of major depressive disorder (MDD) that may result from aberrant lateral habenula hyperactivity. Targeting G-protein coupled receptor 139 (GPR139) may improve anhedonia by modulating lateral habenula…
View article: Association between anhedonia severity and clinical, humanistic, and economic outcomes among US adults with major depressive disorder
Association between anhedonia severity and clinical, humanistic, and economic outcomes among US adults with major depressive disorder Open
Background Anhedonia is a key symptom and part of the diagnostic criterion of major depressive disorder (MDD). However, the relationship between anhedonia severity and the clinical, humanistic, and economic burden among patients with MDD i…
View article: Screening for Depression, Anxiety, and Suicidality: Insights From Electronic Health Record Data in an Academic Medical Center
Screening for Depression, Anxiety, and Suicidality: Insights From Electronic Health Record Data in an Academic Medical Center Open
Introduction: In 2023, 14.6 million adult Americans had serious mental illness, including Major Depressive Disorder (MDD) and anxiety disorders. Further, 12.3 million adult Americans had serious suicidal thoughts and behaviors. This report…
View article: An AI-Powered Healthcare System for Enhanced Patient Care
An AI-Powered Healthcare System for Enhanced Patient Care Open
All over the world, healthcare systems struggle with patient data management, providing correct diagnoses, and running their operations smoothly. The paper outlines the case of our project, an AI-integrated healthcare management system whi…
View article: Should Inflammation Be a Specifier for Major Depression in the <i>DSM-6</i>?
Should Inflammation Be a Specifier for Major Depression in the <i>DSM-6</i>? Open
This Viewpoint discusses the opportunity to include inflammatory biomarkers as specifiers for major depression in the upcoming Sixth Edition of the Diagnostic and Statistical Manual of Mental Disorders ( DSM-6 ).
View article: Pharmacokinetics of Psilocybin: A Systematic Review
Pharmacokinetics of Psilocybin: A Systematic Review Open
Background: Psilocybin has shown promise in therapeutic applications for mental disorders. Understanding the pharmacokinetics of psilocybin and its active metabolite psilocin is crucial for optimizing its clinical use and minimizing advers…
View article: Review on the Impact of Diversity & Inclusion on Work Engagement in the Private Sector Banks of Jharkhand-A Select Study
Review on the Impact of Diversity & Inclusion on Work Engagement in the Private Sector Banks of Jharkhand-A Select Study Open
Diversity and inclusion (D&I) have emerged as critical determinants of employee engagement in the banking sector, influencing motivation, job satisfaction, and overall productivity. This study examines the impact of D&I on work engagement …
View article: Psychedelics and Suicide-Related Outcomes: A Systematic Review
Psychedelics and Suicide-Related Outcomes: A Systematic Review Open
Background/Objectives: Suicide accounts for 1.4% of global deaths, and the slow-acting nature of traditional treatments for suicide risk underscores the need for alternatives. Psychedelic therapies may rapidly reduce suicide risk. This sys…
View article: Spectrum of Cytomorphological Patterns in Enlarged Lymph Nodes: ATertiary Care Center
Spectrum of Cytomorphological Patterns in Enlarged Lymph Nodes: ATertiary Care Center Open
Background: Lymphadenopathy, which is defined as the swelling of lymph nodes, is a frequent clinicalpresentation with a wide differential diagnosis that includes both cancers and benign reactive processes. Fineneedle aspiration cytology (F…
View article: Examining harsh parenting as a moderator in the association between childhood irritability and adolescent suicidal behaviors
Examining harsh parenting as a moderator in the association between childhood irritability and adolescent suicidal behaviors Open
Background Childhood irritability increases the risk of later suicidal behaviors, but the moderators of this association have not been identified. We investigated harsh parenting as a moderator in the association of childhood irritability …
View article: Economic and clinical burden of major depressive disorder with insomnia symptoms in commercially and Medicaid-insured adults in the United States: A retrospective matched cohort study
Economic and clinical burden of major depressive disorder with insomnia symptoms in commercially and Medicaid-insured adults in the United States: A retrospective matched cohort study Open
MDDIS compared to other MDD and non-MDD was associated with significantly higher economic and clinical burden, highlighting the need for effective treatments for this population.
View article: Nanoencapsulated Essential Oils for Post-Harvest Preservation of Stored Cereals: A Review
Nanoencapsulated Essential Oils for Post-Harvest Preservation of Stored Cereals: A Review Open
Cereal grains are frequently attacked by microorganisms and insects during storage and processing, which negatively affects their quality, safety, and market value. Therefore, protecting stored grains from microbial contamination is crucia…
View article: Difficult to Treat Depression
Difficult to Treat Depression Open
The pandemic refocused interest on the burden of depression across the lifespan; the increased efforts to prevent and treat depression are now a priority of health care systems, insurers, patient advocates, digital therapeutic engineers, t…
View article: Study the Immediate Effects of “Primal Reflex Release Technique™” Versus “Neural Tissue Mobilization” on Hip Flexor Tightness in Individuals with a Sedentary Lifestyle
Study the Immediate Effects of “Primal Reflex Release Technique™” Versus “Neural Tissue Mobilization” on Hip Flexor Tightness in Individuals with a Sedentary Lifestyle Open
Background: An inactive life can lead to various problems, such as tightness of muscles, decreased joint mobility, and decreased pliability, which can hinder daily activities. Prolonged sitting puts a lot of force on the muscles, increasin…
View article: Compare the Effectiveness of Mime Therapy on Facial Synkinesis in Idiopathic and Traumatic Lower Motor Neuron Facial Palsy
Compare the Effectiveness of Mime Therapy on Facial Synkinesis in Idiopathic and Traumatic Lower Motor Neuron Facial Palsy Open
Background: The seventh cranial nerve has a core function of regulating emotional displays and speech. Facial paralysis, characterized by the loss of voluntary motor control on one or both sides, is commonly attributed to Bell’s palsy whic…
View article: Formalization, Citizenship and the Challenges of Self‐Governance in Mumbai's Slum Relocation Colonies
Formalization, Citizenship and the Challenges of Self‐Governance in Mumbai's Slum Relocation Colonies Open
The city of Mumbai is engaged in large‐scale urban restructuring efforts. Foundational to these is the demolition of many of the city's informal settlements and the relocation of residents to newly built housing complexes. Often discussed …
View article: Mental-Health Related Disability Leave and Costs Among Patients with Treatment Resistant Depression Initiated on Esketamine and Conventional Therapies
Mental-Health Related Disability Leave and Costs Among Patients with Treatment Resistant Depression Initiated on Esketamine and Conventional Therapies Open
Introduction Treatment resistant depression (TRD) is linked to disproportionate unemployment and productivity burden in the US. Little is known about mental-health (MH)-related disability leave and costs of patients with TRD initiated on e…