Manish Gupta
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View article: Identification of <i>N</i> ‐(2‐(1H‐indol‐3‐yl) ethyl)‐ <i>N</i> ‐benzylacrylamide as Novel Aurora Kinase A Inhibitor for Cancer Therapy: Virtual Screening, Synthesis, MD Simulation, and In Vitro Validation
Identification of <i>N</i> ‐(2‐(1H‐indol‐3‐yl) ethyl)‐ <i>N</i> ‐benzylacrylamide as Novel Aurora Kinase A Inhibitor for Cancer Therapy: Virtual Screening, Synthesis, MD Simulation, and In Vitro Validation Open
Aurora kinase A (AURKA) is a key regulator of mitotic entry, playing a critical role in centrosome separation and overall mitotic progression. Due to its fundamental involvement in cell division and its implication in tumorigenesis, AURKA …
View article: Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer
Efficient identification of new small molecules targeting succinate dehydrogenase in non-small cell lung cancer Open
Our SDH inhibitors halt tumor growth and migration by targeting key substrate binding sites, showing superior efficacy over existing small molecule antagonists. They also modulate SDH protein expression, suggesting a promising dual-targeti…
View article: Exposure-safety Markov modeling of ocular adverse events in patient populations treated with tisotumab vedotin
Exposure-safety Markov modeling of ocular adverse events in patient populations treated with tisotumab vedotin Open
View article: Rescue the rescuers
Rescue the rescuers Open
View article: AI-Powered Personalization for Omnichannel Marketing with Salesforce Agentforce
AI-Powered Personalization for Omnichannel Marketing with Salesforce Agentforce Open
Today’s economy is hyper-connected and customers expect brands to understand their preferences, anticipate their needs, and engage with relevance at every interaction. The challenge lies not only in delivering personalized experiences, but…
View article: Information Extraction from Visually Rich Documents using LLM-based Organization of Documents into Independent Textual Segments
Information Extraction from Visually Rich Documents using LLM-based Organization of Documents into Independent Textual Segments Open
Information extraction (IE) from Visually Rich Documents (VRDs) containing layout features along with text is a critical and well-studied task. Specialized non-LLM NLP-based solutions typically involve training models using both textual an…
View article: Integrating Fuzzy C-Means and DBSCAN: A Hybrid Approach to Medical Data Mining
Integrating Fuzzy C-Means and DBSCAN: A Hybrid Approach to Medical Data Mining Open
Medical data mining is crucial to gain meaningful insights from complex healthcare databases. Medical data sometimes exhibits ambiguity and overlap due to inconsistent diagnosis and varying patient situations. This work proposes a hybrid c…
View article: Assess and Prompt: A Generative RL Framework for Improving Engagement in Online Mental Health Communities
Assess and Prompt: A Generative RL Framework for Improving Engagement in Online Mental Health Communities Open
View article: Acetylation-Mediated Post-Translational Modification of Pyruvate Dehydrogenase Plays a Critical Role in the Regulation of the Cellular Acetylome During Metabolic Stress
Acetylation-Mediated Post-Translational Modification of Pyruvate Dehydrogenase Plays a Critical Role in the Regulation of the Cellular Acetylome During Metabolic Stress Open
Background: Cardiac diseases remain one of the leading causes of death globally, often linked to ischemic conditions that can affect cellular homeostasis and metabolism, which can lead to the development of cardiovascular dysfunction. Cons…
View article: AI-Powered Personalization for Omnichannel Marketing with Salesforce Agent force
AI-Powered Personalization for Omnichannel Marketing with Salesforce Agent force Open
View article: Endophytic Fungi: A Treasure Trove of Antifungal Metabolites
Endophytic Fungi: A Treasure Trove of Antifungal Metabolites Open
Emerging and reemerging fungal infections are very common in nosocomial and non-nosocomial settings in people having poor immunogenic profiles either due to hematopoietic stem cell transplants or are using immunomodulators to treat chronic…
View article: HIV Protein Nef Induces Cardiomyopathy through Induction of Bcl2 and p21
HIV Protein Nef Induces Cardiomyopathy through Induction of Bcl2 and p21 Open
HIV-associated cardiovascular diseases remain a leading cause of death in people living with HIV/AIDS (PLWHA). Although antiretroviral drugs suppress the viral load, they fail to remove the virus entirely. HIV-1 Nef protein is known to pla…
View article: Deciphering the influence of NaCl on social behaviour of <i>Bacillus subtilis</i>
Deciphering the influence of NaCl on social behaviour of <i>Bacillus subtilis</i> Open
Various environmental signals, such as temperature, pH, nutrient levels, salt content and the presence of other microorganisms, can influence biofilm’s development and dynamics. However, the innate mechanisms that govern at the molecular a…
View article: Salesforce CRM and the Integration of Internet of Things (IoT) for Enhanced Customer Insights: A Deep Dive
Salesforce CRM and the Integration of Internet of Things (IoT) for Enhanced Customer Insights: A Deep Dive Open
View article: ReFeR: Improving Evaluation and Reasoning through Hierarchy of Models
ReFeR: Improving Evaluation and Reasoning through Hierarchy of Models Open
Assessing the quality of outputs generated by generative models, such as large language models and vision language models, presents notable challenges. Traditional methods for evaluation typically rely on either human assessments, which ar…
View article: Comparative efficacy of citric acid/tartaric acid/malic acid additive-based polyvinyl alcohol-starch composite films
Comparative efficacy of citric acid/tartaric acid/malic acid additive-based polyvinyl alcohol-starch composite films Open
To ascertain upon the ideal configuration of physico-mechanical qualities, efficient processing techniques, and network stability of the prepared bio-composite films in real-world applications, the polymeric materials shall be subjected to…
View article: Data Privacy and Security in Salesforce CRM: Implications for Organizations
Data Privacy and Security in Salesforce CRM: Implications for Organizations Open
In today’s digitally interconnected business environment, data has become one of the most valuable and vulnerable organizational assets. With the rise in cyberattacks, privacy breaches, and global data protection regulations, the importanc…
View article: Comparative Efficacy of Citric acid/Tartaric acid/Malic acid Additive based Polyvinyl alcohol-Starch Composite Films
Comparative Efficacy of Citric acid/Tartaric acid/Malic acid Additive based Polyvinyl alcohol-Starch Composite Films Open
In this work, these alternate organic acids are blended into polyvinyl alcohol (PVA)-Starch (St) polymer composite to increase the cross-linking, plasticizing, and antibacterial capability of the polymer network. The most expensive of thes…
View article: Efficient identification of new small molecules targeting succinate dehydrogenase in non- small cell lung cancer
Efficient identification of new small molecules targeting succinate dehydrogenase in non- small cell lung cancer Open
Background Lung cancer treatment efficacy remains a challenge due to limited therapeutic targets. Succinate dehydrogenase (SDH) enzyme, a crucial enzyme linking the citric acid cycle and the electron transport chain, is implicated in cance…
View article: The Impact of Salesforce Lightning Web Components (LWC) on UI/UX Design and Development
The Impact of Salesforce Lightning Web Components (LWC) on UI/UX Design and Development Open
View article: A Crypto Yield Model for Staking Return
A Crypto Yield Model for Staking Return Open
We introduce a model that derives a metric to answer the question: what is the expected gain of a staker? We calculate the rewards as the staking return in a Proof-of-Stake (PoS) consensus context. For each period of block validation and b…
View article: Predominantly Orphan Secretome in the Lung Pathogen Mycobacterium abscessus Revealed by a Multipronged Growth-Phase-Driven Strategy
Predominantly Orphan Secretome in the Lung Pathogen Mycobacterium abscessus Revealed by a Multipronged Growth-Phase-Driven Strategy Open
The emerging lung pathogen Mycobacterium abscessus is understudied for its virulence determinants and molecular targets for diagnosis and therapeutics. Here, we report a comprehensive secretome (600 proteins) of this species, which was ide…
View article: Reinforcement Learning for Dynamic Customer Journey Optimization in Salesforce Marketing Cloud
Reinforcement Learning for Dynamic Customer Journey Optimization in Salesforce Marketing Cloud Open
In today’s digital world, delivering personalized customer experiences is paramount for businesses that are aiming to foster engagement and drive conversions. However, many organizations grapple with challenges such as data inconsistencies…
View article: FHIR-Compliant Salesforce Integrations for Unified Patient 360 in Healthcare Cloud
FHIR-Compliant Salesforce Integrations for Unified Patient 360 in Healthcare Cloud Open
In the world of healthcare today, the fragmentation of patient data across disparate systems poses significant challenges to delivering coordinated and personalized care. Electronic Health Records (EHRs), Customer Relationship Management (…
View article: Unravelling Pasteurella Multocida Toxin (Pmt): Structural Insights, Antibiotic Assessment, and Identification of Potential Inhibitors
Unravelling Pasteurella Multocida Toxin (Pmt): Structural Insights, Antibiotic Assessment, and Identification of Potential Inhibitors Open
View article: FHIR-Compliant Salesforce Integrations for Unified Patient 360 in Healthcare Cloud
FHIR-Compliant Salesforce Integrations for Unified Patient 360 in Healthcare Cloud Open
In the world of healthcare today, the fragmentation of patient data across disparate systems poses significant challenges to delivering coordinated and personalized care. Electronic Health Records (EHRs), Customer Relationship Management (…
View article: In-depth feasibility study on conservative surgery, perioperative high-dose-rate brachytherapy, and external beam radiation therapy, with a focus on interstitial brachytherapy for soft tissue sarcomas: Insights from a single-institute experience
In-depth feasibility study on conservative surgery, perioperative high-dose-rate brachytherapy, and external beam radiation therapy, with a focus on interstitial brachytherapy for soft tissue sarcomas: Insights from a single-institute experience Open
This study underscores the feasibility and potential efficacy of PHDRB and EBRT for STS treatment. Despite limitations in sample size, the results are promising, warranting further investigation through multi-centric studies. The use of do…
View article: AI-Driven Next Best Action Models Integrated in Veeva CRM: Architecting Personalization for Healthcare Providers
AI-Driven Next Best Action Models Integrated in Veeva CRM: Architecting Personalization for Healthcare Providers Open
The healthcare industry is undergoing a significant transformation, with artificial intelligence (AI) playing an important role in enhancing healthcare provider (HCP) engagement. AI-driven Next Best Action (NBA) models are at the forefront…
View article: A Comparative Analysis of Post-Disaster Analysis Using Image Processing Techniques
A Comparative Analysis of Post-Disaster Analysis Using Image Processing Techniques Open
Post-disaster recovery is a multifaceted system essential for rebuilding communities and infrastructure. Despite its importance, many limitations obstruct powerful recuperation, main to tremendous loss of life and monetary assets. This pap…
View article: 874 A quantitative systems pharmacology model of head and neck squamous cell carcinoma: a tool for evaluating treatment outcomes for combination therapies
874 A quantitative systems pharmacology model of head and neck squamous cell carcinoma: a tool for evaluating treatment outcomes for combination therapies Open
Background Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide. Different approaches are applied to treat the cancer. Recently, several therapies were approved for treatment of head and neck cancers,…