Manish KC
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View article: Systematic Review of Management Strategies for Alport Syndrome: Implications for Male Patients
Systematic Review of Management Strategies for Alport Syndrome: Implications for Male Patients Open
Background and Aims Alport Syndrome (AS) is a rare genetic disorder characterized by progressive kidney disease, hearing loss, and ocular abnormalities, with an incidence of approximately 1 in 50,000 newborns. Due to the severity of the di…
View article: C-22 | Intravascular Ultrasonography Versus Angiography-Guided Endovascular Interventions in Peripheral Arterial Disease: A Systematic Review and Meta-Analysis
C-22 | Intravascular Ultrasonography Versus Angiography-Guided Endovascular Interventions in Peripheral Arterial Disease: A Systematic Review and Meta-Analysis Open
Intravascular Ultrasonography (IVUS) is a reliable adjunctive imaging modality for endovascular interventions in peripheral arterial disease (PAD) and enables improved treatment planning and optimization of the procedure.We conducted a met…
View article: Adult with Coxsackie B virus-induced cardiomyopathy presents rare case of complicated acute embolic ischaemic stroke
Adult with Coxsackie B virus-induced cardiomyopathy presents rare case of complicated acute embolic ischaemic stroke Open
Introduction and importance: Stroke, a global health concern, often results from embolic events of cardiac origin. Coxsackie B virus (CBV) myocarditis, a common cause of viral heart infections, can lead to cardiac thrombi formation, subseq…
View article: Renal vein thrombosis in a patient secondary to high-grade rhabdoid renal cell carcinoma: a case report and review of literature
Renal vein thrombosis in a patient secondary to high-grade rhabdoid renal cell carcinoma: a case report and review of literature Open
Introduction: Renal cell carcinoma, a common kidney tumour which is often incidentally discovered on imaging, can manifest with atypical symptoms. Renal cell carcinoma with rhabdoid features is a rare occurrence and even rarer in case of a…
View article: Global Perspective on COVID-19 Therapies, Cardiovascular Outcomes, and Implications for Long COVID: A State-of-the-Art Review
Global Perspective on COVID-19 Therapies, Cardiovascular Outcomes, and Implications for Long COVID: A State-of-the-Art Review Open
The COVID-19 pandemic has resulted in many therapies, of which many are repurposed and used for other diseases in the last decade such in Influenza and Ebola. We intend to provide a robust foundation for cardiovascular outcomes of the ther…
View article: Colchicine for Secondary Prevention in Patients with Acute Coronary Syndrome: A Systematic Review and Meta-Analysis
Colchicine for Secondary Prevention in Patients with Acute Coronary Syndrome: A Systematic Review and Meta-Analysis Open
View article: Zavegepant nasal spray for the acute treatment of migraine: A meta analysis
Zavegepant nasal spray for the acute treatment of migraine: A meta analysis Open
Background: Zavegepant nasal spray is a novel CGRP receptor antagonist that has been developed for the acute treatment of migraine – a prevalent disease leading to disability and economic burden. The meta-analysis aims to quantify the effi…
View article: Observational study of organisational responses of 17 US hospitals over the first year of the COVID-19 pandemic
Observational study of organisational responses of 17 US hospitals over the first year of the COVID-19 pandemic Open
Objectives The COVID-19 pandemic has required significant modifications of hospital care. The objective of this study was to examine the operational approaches taken by US hospitals over time in response to the COVID-19 pandemic. Design, s…
View article: Neurokinin 1/3 receptor antagonists for menopausal women: A current systematic review and insights into the investigational non-hormonal therapy
Neurokinin 1/3 receptor antagonists for menopausal women: A current systematic review and insights into the investigational non-hormonal therapy Open
Background: Over 75% of menopausal women experience vasomotor symptoms (VMS), such as night sweats and hot flashes. Despite the prevalence of these symptoms, there is limited data on non-hormonal therapies to alleviate them. Methods: PubMe…
View article: A case report on agenesis of dorsal pancreas with insulin-dependent diabetes mellitus: a rare entity
A case report on agenesis of dorsal pancreas with insulin-dependent diabetes mellitus: a rare entity Open
Introduction: Agenesis of the dorsal pancreas (ADP) is a clinically rare entity that occasionally presents with abdominal pain. It is also association with various disorders of glucose metabolism. Case presentation: A 23-year-old male pres…
View article: Efficacy and safety of different therapies of non-steroidal anti-inflammatory drugs against antibiotic monotherapy in the treatment of uncomplicated lower urinary tract infection: A systematic review
Efficacy and safety of different therapies of non-steroidal anti-inflammatory drugs against antibiotic monotherapy in the treatment of uncomplicated lower urinary tract infection: A systematic review Open
This systematic review aimed to evaluate the efficacy of different non-steroidal anti-inflammatory drugs therapy (monotherapy or combined with antibiotics) against antibiotics monotherapy to understand the possible role of non-steroidal an…
View article: COVID-19 and family planning in the Eastern Mediterranean Region
COVID-19 and family planning in the Eastern Mediterranean Region Open
View article: The Efficacy of vitamin C, thiamine, and corticosteroid therapy in adult sepsis patients: a systematic review and meta-analysis
The Efficacy of vitamin C, thiamine, and corticosteroid therapy in adult sepsis patients: a systematic review and meta-analysis Open
Background: Previous studies have suggested favorable outcomes of hydrocortisone, ascorbic acid (vitamin C), and thiamine (HAT) therapy in patients with sepsis. However, similar results have not been duplicated in sequential studies. This …
View article: Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19
Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19 Open
N-acetylcysteine (NAC) is an abundantly available antioxidant with a wide range of antidotal properties currently best studied for its use in treating acetaminophen overdose. It has a robustly established safety profile with easily tolerat…
View article: Increased risk of mental health disorders in patients with RA during the COVID-19 pandemic: a possible surge and solutions
Increased risk of mental health disorders in patients with RA during the COVID-19 pandemic: a possible surge and solutions Open
View article: Understanding and Promoting Racial Diversity in Healthcare Settings to Address Disparities in Pandemic Crisis Management
Understanding and Promoting Racial Diversity in Healthcare Settings to Address Disparities in Pandemic Crisis Management Open
Background: Health disparities have become apparent since the beginning of the COVID-19 pandemic. When observing racial discrimination in healthcare, self-reported incidences, and perceptions among minority groups in the United States sugg…
View article: Cardio-Pulmonary Sequelae in Recovered COVID-19 Patients: Considerations for Primary Care
Cardio-Pulmonary Sequelae in Recovered COVID-19 Patients: Considerations for Primary Care Open
Background: Current literature lacks characterization of the post-recovery sequelae among COVID-19 patients. This review characterizes the course of clinical, laboratory, radiological findings during the primary infection period, and the c…
View article: Fundus Changes In Pregnancy Induced Hypertension
Fundus Changes In Pregnancy Induced Hypertension Open
BACKGROUND: Ocular involvement in Pregnancy Induced Hypertension (PIH) is common. Hypertensive disorders have a propensity to involve the vascular tissue, which makes the ocular vessels particularly susceptible. Widespread changes in the c…