Manish Dwivedi
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View article: Standardising Neonatal Nursing Handover: Impact of a Quality Improvement Project in a Tertiary Care NICU
Standardising Neonatal Nursing Handover: Impact of a Quality Improvement Project in a Tertiary Care NICU Open
Introduction: A properly written nursing handover is important to avoid medication errors and to improve patient safety outcomes, as well as daily decision-making. There is variation in handover policies across intensive care units, wards,…
View article: Phytochemical Screening of Some Medicinal Plants of Rutaceae Family
Phytochemical Screening of Some Medicinal Plants of Rutaceae Family Open
Present study focuses on testing the leaves and stems of selected three medicinal plants of Rutaceae family found in the Chitrakoot region. The plant parts were extracted using methanol and water through hot methods. These extracts were th…
View article: Urolithin A mitigates behavioural and synaptic deficits associated with epilepsy
Urolithin A mitigates behavioural and synaptic deficits associated with epilepsy Open
The persistence of drug-resistant epilepsy highlights the need for new therapeutic interventions that target novel mechanisms with homeostatic regulations while minimizing side effects. Slow-acting drugs, particularly small molecules of na…
View article: Dynamics based screening of Therapeutic compounds against Helicobacter pylori targeting TNF-α inducing protein
Dynamics based screening of Therapeutic compounds against Helicobacter pylori targeting TNF-α inducing protein Open
In about half of the world's population, Helicobacter pylori (H. pylori) is the cause of stomach ulcers. Due to the extensive use of different drugs to treat H. pylori infections, multidrug resistance has developed, making treatment more d…
View article: Odyssey of environmental and microbial interventions in maize crop improvement
Odyssey of environmental and microbial interventions in maize crop improvement Open
Maize ( Zea mays ) is India’s third-largest grain crop, serving as a primary food source for at least 30% of the population and sustaining 900 million impoverished people globally. The growing human population has led to an increasing dema…
View article: Effect of DMARD Therapy on Inflammatory Biomarkers and Disease Activity in Rheumatoid Arthritis Patients
Effect of DMARD Therapy on Inflammatory Biomarkers and Disease Activity in Rheumatoid Arthritis Patients Open
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and joint destruction. Disease-modifying anti-rheumatic drugs (DMARDs) form the cornerstone of RA management, aiming to control …
View article: “Effectiveness Of Reverse Pressure Softening Technique On The Level Of Breast Engorgement And Breast Feeding Among Postnatal Mothers At Queen Mary Hospital”
“Effectiveness Of Reverse Pressure Softening Technique On The Level Of Breast Engorgement And Breast Feeding Among Postnatal Mothers At Queen Mary Hospital” Open
Background: Breastfeeding residue the most healthy, simple and a feeding method that is least expensive and fulfils the needs to new born. During initial 2 days once baby is born as a part of normal process, breasts of women get accumulate…
View article: Urolithin A mitigates behavioral and synaptic deficits associated with epilepsy through VDAC-1 inhibition: A novel treatment approach
Urolithin A mitigates behavioral and synaptic deficits associated with epilepsy through VDAC-1 inhibition: A novel treatment approach Open
The persistence of drug-resistant epilepsy indicates the need for new therapeutic interventions against novel targets with reduced side effects. One such approach is modifying underlying pathophysiological mechanisms of synaptic plasticity…
View article: An Insight into Immunological Therapeutic Approach against Cancer: Potential Anti-cancer Vaccines
An Insight into Immunological Therapeutic Approach against Cancer: Potential Anti-cancer Vaccines Open
The development of a cancer vaccine comes with its complications and designing and developing a vaccine against foreign invaders such as bacterial and viral particles is not as complex and multi-faceted as the preparation of immunotherapy …
View article: 14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease
14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease Open
Alzheimer’s disease (AD) affects millions of people worldwide and is a gradually worsening neurodegenerative condition. The accumulation of abnormal proteins, such as tau and beta-amyloid, in the brain is a hallmark of AD pathology. 14-3-3…
View article: A pro-oxidant property of vitamin C to overcome the burden of latent Mycobacterium tuberculosis infection: A cross-talk review with Fenton reaction
A pro-oxidant property of vitamin C to overcome the burden of latent Mycobacterium tuberculosis infection: A cross-talk review with Fenton reaction Open
Tuberculosis (TB), caused by the bacillus M. tuberculosis , is one of the deadliest infectious illnesses of our day, along with HIV and malaria.Chemotherapy, the cornerstone of TB control efforts, is jeopardized by the advent of M. tubercu…
View article: Compounds of natural origin as anti-protease in SARS-CoV-2 using combinatory In silico approaches
Compounds of natural origin as anti-protease in SARS-CoV-2 using combinatory In silico approaches Open
SARS-CoV-2 is one of the deadly outbreaks in the present era and still showing its presence around the globe. Researchers have demonstrated various vaccines till now which may provide only protection but the cure is not possible after infe…
View article: Spatiotemporal distribution of malaria prevalence in the district Anuppur, central India
Spatiotemporal distribution of malaria prevalence in the district Anuppur, central India Open
Background: In the current study, 2013±16 medical data were examined to evaluate intervention effects on malaria prevalence in central India. Spatiotemporal variation in the distribution of malaria types (PV, PF, and PV-PF) was also invest…
View article: Deciphering the immunogenic T-cell epitopes from spike protein of SARS-CoV-2 concerning the diverse population of India
Deciphering the immunogenic T-cell epitopes from spike protein of SARS-CoV-2 concerning the diverse population of India Open
Scientists are rigorously looking for an efficient vaccine against the current pandemic due to the SARS-CoV-2 virus. The reverse vaccinology approach may provide us with significant therapeutic leads in this direction and further determina…
View article: How Good are Bacteriophages as an Alternative Therapy to Mitigate Biofilms of Nosocomial Infections
How Good are Bacteriophages as an Alternative Therapy to Mitigate Biofilms of Nosocomial Infections Open
Aditi Singh,1 Sudhakar Padmesh,1 Manish Dwivedi,1 Irena Kostova2 1Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, 226028, India; 2Department of Chemistry, Faculty of Pharmacy, Medical University, …
View article: Anti sickling potential and chemical profiling of traditionally used Woodfordia fruticosa (L.) Kurz leaves
Anti sickling potential and chemical profiling of traditionally used Woodfordia fruticosa (L.) Kurz leaves Open
Woodfordia fruticosa (L.) Kurz is a widely used plant in traditional medicine systems. The tribal communities of Amarkantak, Madhya Pradesh (India) are using this plant for the treatment of general weakness, blood related complications lik…
View article: Secondary metabolite profiling and characterization of diterpenes and flavones from the methanolic extract of Andrographis paniculata using HPLC-LC-MS/MS
Secondary metabolite profiling and characterization of diterpenes and flavones from the methanolic extract of Andrographis paniculata using HPLC-LC-MS/MS Open
Background Andrographis paniculata is a well-known medicinal plant that contains various classes of bioactive secondary metabolites. It is widely used by the traditional medicinal healers for treatment of malaria and other diseases. There …
View article: Microbial community in human gut: a therapeutic prospect and implication in health and diseases
Microbial community in human gut: a therapeutic prospect and implication in health and diseases Open
The interest in the working and functionality of the human gut microbiome has increased drastically over the years. Though the existence of gut microbes has long been speculated for long over the last few decades, a lot of research has spr…
View article: Challenges in Drug Discovery against Tuberculosis
Challenges in Drug Discovery against Tuberculosis Open
Tuberculosis (TB) is one of the deadly diseases in the present era caused by Mycobacterium tuberculosis. Principally, this bacterium attacks the lungs, however, MTB Has been observed affecting any part of the human body including the kidne…
View article: Analytics on Antimicrobial Activity of Lichen Extract
Analytics on Antimicrobial Activity of Lichen Extract Open
Lichen has a great medicinal value and represents the symbiotic relationship between fungi and algae or cyanobacteria. The genus Usnea longissima (Parmeliaceae), is a fruticose lichen with numerous biological activities like antimicrobial,…
View article: Insight into the direct interaction of Na+ with NhaA and mechanistic implications
Insight into the direct interaction of Na+ with NhaA and mechanistic implications Open
Na + /H + antiporters comprise a family of membrane proteins evolutionarily conserved in all kingdoms of life that are essential in cellular ion homeostasis. While several human homologues have long been drug targets, NhaA of Escherichia c…
View article: Prevalence and associated factors of malaria in Pushparajgarh block of district Anuppur, Madhya Pradesh, India
Prevalence and associated factors of malaria in Pushparajgarh block of district Anuppur, Madhya Pradesh, India Open
Background: The current study aimed to determine the prevalence of malaria and its association with seasonality of malaria and socio-demographic variables in a tribal dominated district Anuppur (Madhya Pradesh).Methods: This cross-sectiona…
View article: Impact of Neonatal Counselling on Parental Stress in a Neonatal Intensive Care Unit: A Quasi-experimental Study
Impact of Neonatal Counselling on Parental Stress in a Neonatal Intensive Care Unit: A Quasi-experimental Study Open
Introduction: There are various reasons for stress in the parents of infants admitted in Neonatal Intensive Care Unit (NICU) e.g., sickness, environment and communication with healthcare staff. An effective communication and structured cou…
View article: Targeting the multidrug efflux pump; Tap protein to reduce survival of Mycobacterium tuberculosis
Targeting the multidrug efflux pump; Tap protein to reduce survival of Mycobacterium tuberculosis Open
Tuberculosis (TB) is a serious communicative disease caused by a bacterium named Mycobacterium tuberculosis. Albeit there are vaccines and drugs available to treat the disease, Multidrug-resistant TB (MDR-TB) is still one of the most criti…
View article: Public Health Surveillance System
Public Health Surveillance System Open
To guard people against some grave infectious disease, the surveillance system is a key performance measure of global public health threats and vulnerability. The diseases surveillance system helps in public health monitor, control, and pr…