Manish Saggar
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View article: Refining RDoC Using Individual-Level Task fMRI Factor Models Reveals Reproducible Brain-wide Motifs
Refining RDoC Using Individual-Level Task fMRI Factor Models Reveals Reproducible Brain-wide Motifs Open
The Research Domain Criteria (RDoC) framework was introduced to guide psychiatric research using biologically grounded, dimensional constructs of mental function. However, its current hierarchical domain structure remains largely unvalidat…
View article: The role of meditation in coping with stress during the COVID-19 lockdown: a cross-sectional study of undergraduates in India
The role of meditation in coping with stress during the COVID-19 lockdown: a cross-sectional study of undergraduates in India Open
Background The COVID-19 pandemic significantly impacted mental health worldwide, particularly among college students. This study aimed to evaluate the effects of regular meditation practice on stress and well-being during the COVID-19 lock…
View article: Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression
Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression Open
Objective Stanford Neuromodulation Therapy (SNT) has demonstrated impressive efficacy for treatment-resistant depression (TRD), but its neurophysiological mechanisms remain poorly understood. This study investigated the neurophysiological …
View article: The Topological Architecture of Brain Identity
The Topological Architecture of Brain Identity Open
Accurately identifying individuals from brain activity --functional fingerprinting-- is a powerful tool for understanding individual variability and detecting brain disorders. Most current approaches rely on functional connectivity (FC), w…
View article: A data-driven approach exploring the entrepreneurial-managerial spectrum
A data-driven approach exploring the entrepreneurial-managerial spectrum Open
Entrepreneurs are responsible for starting new ventures, often with high risk and innovation, while managers oversee existing organizations, optimize operations, and achieve predefined goals. Although frequently seen as a dichotomy, entrep…
View article: Excitation-Inhibition Balance and Fronto-Limbic Connectivity Drive TMS Treatment Outcomes in Refractory Depression
Excitation-Inhibition Balance and Fronto-Limbic Connectivity Drive TMS Treatment Outcomes in Refractory Depression Open
Depression affects over 350 million people worldwide, with treatment resistance occurring in up to 30% of cases. Intermittent theta burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC) has emerged as a promisi…
View article: Revealing Changes in Linear and Nonlinear Functional Connectivity After Psilocybin and Escitalopram Treatment in Patients with Depression
Revealing Changes in Linear and Nonlinear Functional Connectivity After Psilocybin and Escitalopram Treatment in Patients with Depression Open
Major Depressive Disorder (MDD) is typically characterized by altered linear functional connectivity (FC) across large-scale brain networks. Yet, it is unclear whether similar alterations are observed when nonlinear FC is examined. This st…
View article: Quantitative T1 mapping indicates elevated white matter myelin in children with RASopathies
Quantitative T1 mapping indicates elevated white matter myelin in children with RASopathies Open
Background Evidence suggests pathological roles of myelination in neurodevelopmental disorders, but our understanding is limited. We investigated quantitative T1 mapping (QT1) as a clinically feasible tool for measuring myelination in chil…
View article: Temporal Complexity as a Biomarker for Antidepressant Response: Insights from the Distance-Scaled Complexity Index (DSCI) in Stanford Neuromodulation Therapy
Temporal Complexity as a Biomarker for Antidepressant Response: Insights from the Distance-Scaled Complexity Index (DSCI) in Stanford Neuromodulation Therapy Open
View article: A data-driven approach exploring the entrepreneurial-managerial spectrum
A data-driven approach exploring the entrepreneurial-managerial spectrum Open
Entrepreneurs are responsible for starting new ventures, often with high risk and innovation, while managers oversee existing organizations, optimize operations, and achieve predefined goals. Although frequently seen as a dichotomy, entrep…
View article: Concurrent single-pulse (sp) TMS/fMRI to reveal the causal connectome in healthy and patient populations
Concurrent single-pulse (sp) TMS/fMRI to reveal the causal connectome in healthy and patient populations Open
Neuroimaging and cognitive neuroscience studies have identified neural circuits linked to anxiety, mood, and trauma-related symptoms and focused on their interaction with the medial prefrontal default mode circuitry. Despite these advances…
View article: Predicting Task Activation Maps from Resting-State Functional Connectivity using Deep Learning
Predicting Task Activation Maps from Resting-State Functional Connectivity using Deep Learning Open
Deep learning has been proven effective in predicting brain activation patterns from resting-state features. In this work, using resting state and task fMRI data from the Human Connectome Project (HCP), we replicate the state-of-the-art de…
View article: Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial
Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial Open
View article: Densely sampled stimulus-response map of human cortex with single pulse TMS-EEG and its relation to whole brain neuroimaging measures
Densely sampled stimulus-response map of human cortex with single pulse TMS-EEG and its relation to whole brain neuroimaging measures Open
Large-scale networks underpin brain functions. How such networks respond to focal stimulation can help decipher complex brain processes and optimize brain stimulation treatments. To map such stimulation-response patterns across the brain n…
View article: A Data-Driven Latent Variable Approach to Validating the Research Domain Criteria Framework
A Data-Driven Latent Variable Approach to Validating the Research Domain Criteria Framework Open
Despite the widespread use of the Research Domain Criteria (RDoC) framework in psychiatry and neuroscience, recent studies suggest that the RDoC is insufficiently specific or excessively broad relative to the underlying brain circuitry it …
View article: The control costs of human brain dynamics
The control costs of human brain dynamics Open
The human brain is a complex system with high metabolic demands and extensive connectivity that requires control to balance energy consumption and functional efficiency over time. How this control is manifested on a whole-brain scale is la…
View article: Deconstructing the Mapper algorithm to extract richer topological and temporal features from functional neuroimaging data
Deconstructing the Mapper algorithm to extract richer topological and temporal features from functional neuroimaging data Open
Capturing and tracking large-scale brain activity dynamics holds the potential to deepen our understanding of cognition. Previously, tools from Topological Data Analysis, especially Mapper, have been successfully used to mine brain activit…
View article: Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders
Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders Open
View article: Network effects of Stanford Neuromodulation Therapy (SNT) in treatment-resistant major depressive disorder: a randomized, controlled trial
Network effects of Stanford Neuromodulation Therapy (SNT) in treatment-resistant major depressive disorder: a randomized, controlled trial Open
View article: Current opinions on the present and future use of functional near-infrared spectroscopy in psychiatry
Current opinions on the present and future use of functional near-infrared spectroscopy in psychiatry Open
Functional near-infrared spectroscopy (fNIRS) is an optical imaging technique for assessing human brain activity by noninvasively measuring the fluctuation of cerebral oxygenated- and deoxygenated-hemoglobin concentrations associated with …
View article: Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders
Cross-attractor modeling of resting-state functional connectivity in psychiatric disorders Open
Resting-state functional connectivity (RSFC) is altered across various psychiatric disorders. Brain network modeling (BNM) has the potential to reveal the neurobiological underpinnings of such abnormalities by dynamically modeling the stru…
View article: Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder
Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder Open
View article: Neural resources shift under Methylphenidate: A computational approach to examine anxiety-cognition interplay
Neural resources shift under Methylphenidate: A computational approach to examine anxiety-cognition interplay Open
The reciprocal interplay between anxiety and cognition is well documented. Anxiety negatively impacts cognition, while cognitive engagement can down-regulate anxiety. The brain mechanisms and dynamics underlying such interplay are not full…
View article: Temporal Mapper: transition networks in simulated and real neural dynamics
Temporal Mapper: transition networks in simulated and real neural dynamics Open
Characterizing large-scale dynamic organization of the brain relies on both data-driven and mechanistic modeling, which demands a low vs. high level of prior knowledge and assumptions about how constituents of the brain interact. However, …
View article: Brief intensive social gaze training normalizes functional brain connectivity in boys with fragile X syndrome
Brief intensive social gaze training normalizes functional brain connectivity in boys with fragile X syndrome Open
Boys with fragile X syndrome (FXS), the leading known genetic cause of autism spectrum disorder (ASD), demonstrate significant impairments in social gaze and associated weaknesses in communication, social interaction, and other areas of ad…
View article: Dysfunctional cortical gradient topography in treatment resistant major depression
Dysfunctional cortical gradient topography in treatment resistant major depression Open
Background Treatment-Resistant Depression (TRD) refers to patients with major depressive disorder who do not remit after two or more antidepressant trials. TRD is common and highly debilitating, but its neurobiological basis remains poorly…
View article: Spontaneous and deliberate modes of creativity: Multitask eigen-connectivity analysis captures latent cognitive modes during creative thinking
Spontaneous and deliberate modes of creativity: Multitask eigen-connectivity analysis captures latent cognitive modes during creative thinking Open
View article: Precision dynamical mapping using topological data analysis reveals a unique hub-like <i>transition state</i> at rest
Precision dynamical mapping using topological data analysis reveals a unique hub-like <i>transition state</i> at rest Open
Even in the absence of external stimuli, neural activity is both highly dynamic and organized across multiple spatiotemporal scales. The continuous evolution of brain activity patterns during rest is believed to help maintain a rich repert…
View article: Dynamic autonomic nervous system patterns differentiate human emotions and manifest in resting physiology
Dynamic autonomic nervous system patterns differentiate human emotions and manifest in resting physiology Open
Whether activity in the autonomic nervous system differs during distinct emotions remains controversial. We obtained continuous multichannel recordings of autonomic nervous system activity in healthy adults during a video-based emotional r…
View article: Brain mitochondrial diversity and network organization predict anxiety-like behavior in mice
Brain mitochondrial diversity and network organization predict anxiety-like behavior in mice Open
The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior relationship has not been systematically studied on a brain-wide scale. Here we examined th…